4.7 Article Data Paper

ICEO, a biological ontology for representing and analyzing bacterial integrative and conjugative elements

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Summary: Mobile genetic elements (MGEs) play a key role in the spread of antibiotic resistance, with the coevolution between bacteria and MGEs shaping their transfer and stability. Despite the abundance of ICEs, the dynamics of ICE-bacterium coevolution remain largely unexplored. Both conjugative plasmids and ICEs are transferred via type IV secretion systems, but the immunity to segregational loss in ICEs results in different evolutionary paths for ICE-bacterium associations compared to plasmid-bacterium associations.

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