期刊
ACS CENTRAL SCIENCE
卷 8, 期 1, 页码 118-121出版社
AMER CHEMICAL SOC
DOI: 10.1021/acscentsci.1c01153
关键词
-
资金
- NIH [R35GM119855, T32GM066698, SCR _017852, S10OD025063]
- Camille Dreyfus Teacher-Scholar Program
- NSERC
This study demonstrates a molecular prosthetic approach that can substantially prolong imaging in neurons and cardiomyocytes.
Voltage-sensitive fluorescent reporters can reveal fast changes in the membrane potential in neurons and cardiomyocytes. However, in many cases, illumination in the presence of the fluorescent reporters results in disruptions to the action potential shape that limits the length of recording sessions. We show here that a molecular prosthetic approach, previously limited to fluorophores, rather than indicators, can be used to substantially prolong imaging in neurons and cardiomyocytes.
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