期刊
INTERNATIONAL JOURNAL OF DERMATOLOGY
卷 56, 期 1, 页码 68-74出版社
WILEY
DOI: 10.1111/ijd.13402
关键词
tinea pedis; onychomycosis; diabetes; fungal infections; antifungal susceptibility
类别
BackgroundDiabetes patients are particularly susceptible to fungal infections because their vascular and immunological systems are compromised. ObjectivesThe present study aimed to determine prevalences of tinea pedis and onychomycosis, factors predisposing to their development, and antifungal susceptibilities of causative fungal species against fluconazole, itraconazole, and terbinafine in patients with type2 diabetes mellitus (DM). MethodsStudy groups were defined according to hemoglobin A1C rates of 6.5% for the diabetes group and 5.7% for control subjects. A total of 600 diabetes subjects and 152 control subjects were evaluated. Rates of onychomycosis and tinea pedis in diabetes patients, and associations with age, gender, blood glucose level, duration of diabetes and serum lipid profile were investigated, as were the distribution and antifungal susceptibility of agents isolated. ResultsPatients with onychomycosis and/or tinea pedis numbered 85 in the diabetes group and nine in the control group (P=0.006). The development of onychomycosis or tinea pedis was significantly related to increasing age and male gender. Although the most common agents were dermatophytes, non-dermatophyte fungal isolates were not uncommon. Terbinafine was the most effective drug against dermatophytes but was invalid for non-dermatophyte isolates by invitro antifungal susceptibility testing. ConclusionsThe development of onychomycosis or tinea pedis was significantly related to type2 DM, increasing age, and male gender. The most common isolate was Trichophyton rubrum. The isolation and identification of the fungus is important to the effective management of tinea pedis and onychomycosis in diabetes patients because non-dermatophyte fungi can cause these infections.
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