4.7 Article

Inhibition of GCN2 alleviates hepatic steatosis and oxidative stress in obese mice: Involvement of NRF2 regulation

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Citrulline supplementation attenuates the development of non-alcoholic steatohepatitis in female mice through mechanisms involving intestinal arginase

Dragana Rajcic et al.

Summary: The study found that the nonproteogenic amino acid L-citrulline (L-Cit) can attenuate the progression of pre-existing diet-induced non-alcoholic fatty liver disease (NAFLD), and this protective effect is related to a decrease in bacterial endotoxin translocation, loss of tight junction proteins, and reduction in arginase activity in small intestinal tissue.

REDOX BIOLOGY (2021)

Article Medicine, Research & Experimental

Taurine Reduces Liver Damage in Non-Alcoholic Fatty Liver Disease Model in Rats by Down-Regulating IL-9 and Tumor Growth Factor TGF-β

Z. Yao et al.

Summary: In a rat model, taurine was found to prevent and treat non-alcoholic fatty liver disease by reducing the expression of TGF-beta and IL-9, alleviating liver and ileal mucosa damage.

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE (2021)

Article Pharmacology & Pharmacy

Knockdown of GCN2 inhibits high glucose-induced oxidative stress and apoptosis in retinal pigment epithelial cells

Xiaohui Zhang et al.

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2020)

Review Biochemistry & Molecular Biology

Roles of Nrf2 in Liver Diseases: Molecular, Pharmacological, and Epigenetic Aspects

Marina Galicia-Moreno et al.

ANTIOXIDANTS (2020)

Review Biochemistry & Molecular Biology

Mitochondrial damage and iron metabolic dysregulation in hepatitis C virus infection

Keisuke Hino et al.

FREE RADICAL BIOLOGY AND MEDICINE (2019)

Article Multidisciplinary Sciences

Activation of GCN2 by the ribosomal P-stalk

Alison J. Inglis et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Review Biochemistry & Molecular Biology

Towards a model of GCN2 activation

Glenn R. Masson

BIOCHEMICAL SOCIETY TRANSACTIONS (2019)

Article Biochemistry & Molecular Biology

GCN2 deficiency protects against high fat diet induced hepatic steatosis and insulin resistance in mice

Shasha Liu et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2018)

Article Medicine, Research & Experimental

Curcumin regulates endogenous and exogenous metabolism via Nrf2-FXR-LXR pathway in NAFLD mice

Caixia Yan et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

Article Gastroenterology & Hepatology

Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2)

Ritu S. Sharma et al.

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY (2018)

Article Biochemistry & Molecular Biology

Halofuginone enhances the chemo-sensitivity of cancer cells by suppressing NRF2 accumulation

Kouhei Tsuchida et al.

FREE RADICAL BIOLOGY AND MEDICINE (2017)

Article Biochemistry & Molecular Biology

Small Molecule Inhibitor of NRF2 Selectively Intervenes Therapeutic Resistance in KEAP1-Deficient NSCLC Tumors

Anju Singh et al.

ACS CHEMICAL BIOLOGY (2016)

Article Biochemistry & Molecular Biology

Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis

Da Hyun Lee et al.

FREE RADICAL BIOLOGY AND MEDICINE (2016)

Editorial Material Gastroenterology & Hepatology

Gut-liver immunity

Palak J. Trivedi et al.

JOURNAL OF HEPATOLOGY (2016)

Article Cell Biology

GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2

Jiangbin Ye et al.

GENES & DEVELOPMENT (2015)

Review Biochemistry & Molecular Biology

Role of NADPH oxidases in the redox biology of liver fibrosis

Eva Crosas-Molist et al.

REDOX BIOLOGY (2015)

Article Biochemical Research Methods

Trimmomatic: a flexible trimmer for Illumina sequence data

Anthony M. Bolger et al.

BIOINFORMATICS (2014)

Review Pathology

Alcoholic and non-alcoholic steatohepatitis

Manuela G. Neuman et al.

EXPERIMENTAL AND MOLECULAR PATHOLOGY (2014)

Review Gastroenterology & Hepatology

Oxidative stress as a crucial factor in liver diseases

Halina Cichoz-Lach et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2014)

Review Gastroenterology & Hepatology

Lipotoxicity in the liver

Veronika Zambo et al.

WORLD JOURNAL OF HEPATOLOGY (2013)

Article Biochemistry & Molecular Biology

Structural and Functional Characterization of Nrf2 Degradation by the Glycogen Synthase Kinase 3/β-TrCP Axis

Patricia Rada et al.

MOLECULAR AND CELLULAR BIOLOGY (2012)

Article Biochemistry & Molecular Biology

Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase

Tracy L. Keller et al.

NATURE CHEMICAL BIOLOGY (2012)

Article Biochemistry & Molecular Biology

Identification of GCN2 as new redox regulator for oxidative stress prevention in vivo

Cedric Chaveroux et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2011)

Article Biochemical Research Methods

RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome

Bo Li et al.

BMC BIOINFORMATICS (2011)

Review Neurosciences

GSK-3: functional insights from cell biology and animal models

Oksana Kaidanovich-Beilin et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2011)

Article Biochemical Research Methods

DEGseq: an R package for identifying differentially expressed genes from RNA-seq data

Likun Wang et al.

BIOINFORMATICS (2010)

Article Biochemistry & Molecular Biology

Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis

Sudhir Chowdhry et al.

FREE RADICAL BIOLOGY AND MEDICINE (2010)

Article Pharmacology & Pharmacy

Enhanced expression of Nrf2 in mice attenuates the fatty liver produced by a methionine- and choline-deficient diet

Yu-Kun Jennifer Zhang et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2010)

Article Biochemistry & Molecular Biology

Direct Interaction between Nrf2 and p21Cip1/WAF1 Upregulates the Nrf2-Mediated Antioxidant Response

Weimin Chen et al.

MOLECULAR CELL (2009)

Article Endocrinology & Metabolism

Evaluating the glucose tolerance test in mice

Sofianos Andrikopoulos et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2008)

Article Biochemistry & Molecular Biology

Heterodimerization with small Maf proteins enhances nuclear retention of Nrf2 via masking the NESzip motif

Wenge Li et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2008)

Article Biochemistry & Molecular Biology

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate for proteasomal degradation of Nrf2

A Kobayashi et al.

MOLECULAR AND CELLULAR BIOLOGY (2004)

Article Biochemistry & Molecular Biology

Regulated translation initiation controls stress-induced gene expression in mammalian cells

HP Harding et al.

MOLECULAR CELL (2000)