期刊
PROBIOTICS AND ANTIMICROBIAL PROTEINS
卷 15, 期 3, 页码 738-748出版社
SPRINGER
DOI: 10.1007/s12602-021-09900-6
关键词
Probiotic; Diarrhea prevention; Gastrointestinal symptoms; Hospital gastrointestinal symptoms
This study evaluated the efficacy of Bifidobacterium lactis CCT 7858 in preventing antibiotic-related diarrhea and improving gastrointestinal symptoms. The results showed that this strain can reduce diarrhea and gastrointestinal symptoms.
Diarrhea is one of the most frequent side effects of antibiotic treatment and occurs in 25 to 40% of patients in use. One potential strategy to prevent this side effect is the concurrent use of probiotics. This study evaluated the efficacy of the strain Bifidobacterium lactis CCT 7858 in the prevention of diarrhea and improvement of gastrointestinal symptoms in hospitalized patients using antibiotics. This was a randomized, blinded, placebo-controlled clinical trial. This study included 104 patients in antibiotic treatment. Patients were randomized into two groups: placebo (maltodextrin) and intervention (strain Bifidobacterium lactis CCT 7858 at 9 x 10(10) CFU concentration; GABBIA (R) Biotecnology, Santa Catarina, Brazil). Patients were supplemented depending on the duration of antibiotic therapy, and both were evaluated with scales in two moments: before and after treatment. We included 104 hospitalized patients. In follow-up, 38 (74.5%) of the B. lactis group have no reported diarrhea. In secondary outcomes, in five day strong abdominal distension was reported in 4 (7,3) placebo group and not reported in B. lactis. Abdominal noises, nausea, and vomiting were not registered in any group. B. lactis strain has been considered safe and with several benefits, including reduction of soft stools and gastrointestinal symptoms how abdominal noise, pain and distension, as well reduction of diarrhea.
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