期刊
ORGANIC CHEMISTRY FRONTIERS
卷 9, 期 4, 页码 1115-1120出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1qo01655e
关键词
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资金
- National Natural Science Foundation of China [21871283]
- project of Science and Technology Commission of Shanghai Municipality in China [21010503800]
- Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
- Shanghai Engineering Research Center of Green Fluoropharmaceutical Technology
- Science Research Foundation of Shanghai Institute of Technology
By utilizing a radical sulfur dioxide insertion and fluorination strategy, we have successfully developed an efficient method for synthesizing aliphatic sulfonyl fluorides. This method utilizes readily available carboxylic acids, a reductant, a sulfur dioxide surrogate, and the electrophilic fluorination reagent NFSI under reduction conditions. The protocol allows for the synthesis of various aliphatic sulfonyl fluorides and is compatible with a wide range of functional groups.
Based on a radical sulfur dioxide insertion and fluorination strategy, we have developed an efficient method for aliphatic sulfonyl fluoride synthesis using abundant carboxylic acids, a reductant, a sulfur dioxide surrogate and the electrophilic fluorination reagent N-fluorobenzenesulfonimide (NFSI) under reduction conditions. This protocol provides a convenient synthetic pathway for various aliphatic sulfonyl fluorides and tolerates a wide range of functional groups.
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