Electrochemical synthesis of functionalized gem-difluoroalkenes with diverse alkyl sources via a defluorinative alkylation process

An electrochemical defluorinative alkylation protocol of alpha-trifluoromethyl alkenes is described. This reaction enables the preparation of functionalized gem-difluoroalkenes with the use of diverse alkyl sources including organohalides, N-hydroxyphthalimide (NHP) esters and Katritzky salts. This method exhibits lots of synthetic advantages including mild conditions, simple operation, and convenience of amplification, and provides a new route for the synthesis of gem-difluoroalkenes.

Automated summary

An electrochemical protocol for the defluorinative alkylation of alpha-trifluoromethyl alkenes is described, enabling the preparation of functionalized gem-difluoroalkenes using diverse alkyl sources. This method provides a new route for the synthesis of gem-difluoroalkenes, offering advantages such as mild conditions, simple operation, and convenience of amplification.