期刊
ORGANIC CHEMISTRY FRONTIERS
卷 9, 期 4, 页码 1137-1142出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1qo01463c
关键词
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资金
- National Natural Science Foundation of China [81872440, 22101055]
- Guangzhou Science and Technology Program [201807010041]
- Guangdong Science and Technology Program [2018A030310240, 2018A030313022]
- Scientific Research Foundation of Guangdong Pharmaceutical University [51340332, 51340336]
In this study, it was demonstrated that linear unsymmetrical diaryliodoniums can undergo one-pot cyclization/arylation using a dual nickel/palladium metal system, and the in situ generated benzoxazole motifs can be utilized as directing groups for subsequent C-H activated arylation from the unwanted aryl iodide, exhibiting good atom economy and regioselectivity.
Linear diaryliodoniums often undergo only single arylation and leave equivalent aryl iodide as waste. Herein, we demonstrate that linear unsymmetrical diaryliodoniums could be tuned by a dual nickel/palladium metal system to accomplish one-pot cyclization/arylation. Of note, the in situ generated benzoxazole motifs could then be utilized as directing groups for subsequent C-H activated arylation from the often unwanted aryl iodide, exhibiting good reactions with atom economy and regioselectivity.
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