Synthesis of 2-trifluoromethylquinolines through rhodium-catalysed redox-neutral [3+3] annulation between anilines and CF3-ynones using traceless directing groups

Rhodium-catalysed regioselective redox-neutral [3 + 3]-cycloaddition of anilines with CF3-ynones was achieved via a traceless directing group strategy. A variety of substituted 2-trifluromethylquinoline compounds were obtained in good to excellent yields, which exhibited favorable blue emission properties.

Automated summary

The regioselective redox-neutral [3 + 3]-cycloaddition of anilines with CF3-ynones was achieved using a traceless directing group strategy catalyzed by rhodium. A variety of substituted 2-trifluromethylquinoline compounds were obtained in good to excellent yields, exhibiting favorable blue emission properties.