Electrophilic N-trifluoromethylthiophthalimide as a fluorinated reagent in the synthesis of acyl fluorides

Herein we report the deoxygenated fluorination of readily available carboxylic acids. A series of acyl fluorides have been synthesized using shelf-stable N-trifluoromethylthiophthalimide as a fluorinated reagent for the first time. Scale-up reactions and sequential cross-couplings were performed successfully to demonstrate the practicability of this fluorination protocol.

Automated summary

This study presents a novel method for deoxygenated fluorination of readily available carboxylic acids, resulting in the synthesis of a series of acyl fluorides. Scale-up reactions and sequential cross-couplings successfully demonstrated the feasibility and practicality of this fluorination protocol.