Redox-neutral dehydrogenative cross-coupling of alcohols and amines enabled by nickel catalysis

Presented herein is a facile and straightforward synthetic method for the construction of amides via Ni/NHC-catalyzed amidation of alcohols with amines. The strategy exhibits various advantages over existing methods, including base metal catalysis, commercially available catalyst, removal of oxidant, good yields (up to 95%), good functional group tolerance and substrate generality. Moreover, the nature of the reaction was revealed by NMR spectroscopy and isolation of intermediates.

Automated summary

The facile synthetic method presented involves the construction of amides from alcohols and amines catalyzed by Ni/NHC, with advantages such as base metal catalysis, commercially available catalyst, good yields (up to 95%), and substrate generality. The nature of the reaction was revealed through NMR spectroscopy and isolation of intermediates.