Rhodium-catalyzed dearomative rearrangement of 2-oxypyridines with cyclopropenes: access to N-alkylated 2-pyridones

A rhodium-catalyzed dearomative rearrangement reaction of 2-oxypyridines has been developed by using cyclopropenes as carbene precursors. This protocol features broad substrate scope and mild reaction conditions, providing a reliable and practical approach for the highly efficient synthesis of 2-alkylated 2-pyridone derivatives from readily available O-substituted pyridine compounds.

Automated summary

A new rhodium-catalyzed reaction has been developed using cyclopropenes as carbene precursors, enabling the synthesis of 2-alkylated 2-pyridone derivatives from 2-oxypyridines. This method offers broad substrate scope, mild reaction conditions and a reliable approach for the efficient synthesis of the desired compounds.