4.6 Article

Accumulation of dysfunctional tumor-infiltrating PD-1+DCs links PD-1/PD-L1 blockade immunotherapeutic response in cervical cancer

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Summary: Cervical cancer, primarily caused by persistent high-risk HPV infection, remains the fourth most common cancer affecting women worldwide. Current treatments, such as radiotherapy, chemotherapy, and surgical resection, have limited efficacy and significant side effects against advanced disease. Immunotherapy shows promise in reversing immunosuppressive environments and enhancing T-cell functioning to improve treatment success.

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