期刊
MOLECULAR METABOLISM
卷 54, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.molmet.2021.101333
关键词
Retina; Neuronal; Vascular damage; Endothelial cells; Muller cells
资金
- Deutsche For-schungsgemeinschaft [GRK 1874-2]
The study found that glucosamine may have a protective effect on diabetic retinopathy, but may cause damage to the blood vessels in the normal retina.
Objective: Glucosamine, an intermetabolite of the hexosamine biosynthesis pathway (HBP), is a widely used nutritional supplement in osteoarthritis patients, a subset of whom also suffer from diabetes. HBP is activated in diabetic retinopathy (DR). The aim of this study is to investigate the yet unclear effects of glucosamine on DR. Methods: In this study, we tested the effect of glucosamine on vascular and neuronal pathology in a mouse model of streptozotocin-induced DR in vivo and on cultured endothelial and Muller cells to elucidate the underlying mechanisms of action in vitro. Results: Glucosamine did not alter the blood glucose or HbA1c levels in the animals, but induced body weight gain in the non-diabetic animals. Interestingly, the impaired neuronal function in diabetic animals could be prevented by glucosamine treatment. Correspondingly, the activation of Muller cells was prevented in the retina as well as in cell culture. Conversely, glucosamine administration in the normal retina damaged the retinal vasculature by increasing pericyte loss and acellular capillary formation, likely by interfering with endothelial survival signals as seen in vitro in cultured endothelial cells. Nevertheless, under diabetic conditions, no further increase in the detrimental effects were observed. Conclusions: In conclusion, the effects of glucosamine supplementation in the retina appear to be a double-edged sword: neuronal protection in the diabetic retina and vascular damage in the normal retina. Thus, glucosamine supplementation in osteoarthritis patients with or without diabetes should be taken with care. (C) 2021 The Author(s). Published by Elsevier GmbH.
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