4.3 Article

Cetylpyridinium chloride promotes disaggregation of SARS-CoV-2 virus-like particles

期刊

JOURNAL OF ORAL MICROBIOLOGY
卷 14, 期 1, 页码 -

出版社

TAYLOR & FRANCIS LTD
DOI: 10.1080/20002297.2022.2030094

关键词

SARS-CoV-2; cetylpyridinium chloride; virology; virus-like particles; membrane disaggregation

资金

  1. Ministerio de Ciencia, Innovacion y Universidades [PTQ2019-010608]
  2. Generalitat Valenciana [PROMETEU/2019/065]
  3. Ministerio de Ciencia e Innovacion [PID2020119111GB-I00]
  4. Instituto de Salud Carlos III [COV20/01265]

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The study showed that CPC can cause the rupture of SARS-CoV-2 VLP membranes, suggesting that including it in mouthwashes could be a prophylactic strategy to prevent the spread of the virus.
Background SARS-CoV-2 is continuously disseminating worldwide. The development of strategies to break transmission is mandatory. Aim of the study To investigate the potential of cetylpyridinium chloride (CPC) as a viral inhibitor. Methods SARS-CoV-2 Virus Like-Particles (VLPs) were incubated with CPC, a potent surfactant routinely included in mouthwash preparations. Results Concentrations of 0.05% CPC (w/v) commonly used in mouthwash preparations are sufficient to promote the rupture of SARS-CoV-2 VLP membranes. Conclusion Including CPC in mouthwashes could be a prophylactic strategy to keep SARS-CoV-2 from spreading.

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