Reactivation of EBV and CMV in Severe COVID-19-Epiphenomena or Trigger of Hyperinflammation in Need of Treatment? A Large Case Series of Critically ill Patients

Article Infectious Diseases

EBV DNA increase in COVID-19 patients with impaired lymphocyte subpopulation count

Stefania Paolucci et al.

Summary: This study monitored the immunologic profile and opportunistic viral DNA increase in Italian patients with COVID-19 to identify markers of disease severity. It found a correlation between reduced CD8(+) T cells and NK counts, elevated EBV DNA levels, and COVID-19 severity, highlighting the importance of further evaluating the relationship between EBV load and disease severity in longitudinal studies.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2021)

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Article Critical Care Medicine

Preemptive ganciclovir for mechanically ventilated patients with cytomegalovirus reactivation

Laurent Papazian et al.

Summary: In patients mechanically ventilated for more than 96 hours with CMV reactivation in blood, preemptive ganciclovir did not improve the outcome.

ANNALS OF INTENSIVE CARE (2021)

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Article Infectious Diseases

Herpesvirus reactivation during severe COVID-19 and high rate of immune defect

A. Saade et al.

Summary: The study found that the incidence of herpesvirus reactivation in patients treated in the ICU for severe COVID-19 was high, but in most cases did not require antiviral treatment. Pre-existing hematological malignancy and solid organ transplantation were independently associated with viral reactivation, but viral reactivation was not associated with mortality.

INFECTIOUS DISEASES NOW (2021)

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Article Infectious Diseases

High incidence of Epstein-Barr virus, cytomegalovirus, and human-herpes virus-6 reactivations in critically ill patients with COVID-19

A. Simonnet et al.

Summary: Critically ill patients with COVID-19 in the ICU are prone to herpesvirus reactivation, particularly with EBV, which occurs early and is associated with longer ICU stays.

INFECTIOUS DISEASES NOW (2021)

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Letter Critical Care Medicine