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Article
Virology
Stephen J. Halpin et al.
Summary: This study is the first report from the United Kingdom on post-discharge symptoms in COVID-19 survivors, identifying fatigue, breathlessness, and psychological distress as common symptoms that require planning of rehabilitation services for appropriate management.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Infectious Diseases
Qiutang Xiong et al.
Summary: The study described the common clinical sequelae in COVID-19 survivors discharged from the hospital for more than 3 months, including general symptoms, respiratory symptoms, cardiovascular-related symptoms, psychosocial symptoms, and alopecia. Female patients were more likely to experience physical decline/fatigue, postactivity polypnoea, and alopecia.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Infectious Diseases
Claudia Carvalho-Schneider et al.
Summary: In noncritical COVID-19 patients, most individuals continued to experience symptoms up to 2 months after symptom onset, with the main complaints being anosmia/ageusia, dyspnoea, or asthenia. Factors associated with persistent symptoms included age 40-60 years old, hospital admission, and abnormal auscultation at symptom onset.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Medicine, General & Internal
Chaolin Huang et al.
Summary: This study aimed to investigate the long-term health consequences of discharged COVID-19 patients and associated risk factors, particularly disease severity. Patients with more severe illness during hospitalization showed more severe impaired pulmonary diffusion capacities and abnormal chest imaging manifestations, highlighting the need for targeted interventions for long-term recovery.
Article
Immunology
Karen B. Jacobson et al.
Summary: The study assessed 118 individuals 3-4 months after their initial COVID-19 diagnosis and found significant persistent symptoms and functional impairment, even in non-hospitalized patients with COVID-19.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Carole H. Sudre et al.
Summary: Reports on long-lasting COVID-19 symptoms, known as 'long COVID', are increasing. Analysis of data from over 4,000 COVID-19 cases revealed that long COVID is more common in older individuals, those with higher body mass index, and females. Experiencing more than five symptoms in the first week of illness was associated with long COVID. A simple model showed promise in distinguishing between short and long COVID cases early in the disease.
Article
Environmental Sciences
Knut Stavem et al.
Summary: The study found a high prevalence of fatigue following COVID-19, which was higher than in a general norm population. Fatigue symptoms were most prevalent among women, individuals with a high symptom load, or confusion during the acute phase of COVID-19.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Infectious Diseases
Yolanda Meije et al.
Summary: This study aimed to describe the long-term outcomes of COVID-19 survivors who were followed up both at an outpatient facility and by telephone. It found that most patients still experienced symptoms, with those having lower Pao(2)/Fio(2) ratios during acute illness requiring special attention.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Medicine, General & Internal
Luc Morin et al.
Summary: After 4 months of hospitalization for COVID-19, a significant proportion of patients reported new symptoms and abnormalities in lung scans were common. Further research is needed to understand the long-term consequences of COVID-19.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Review
Medicine, General & Internal
Destin Groff et al.
Summary: This systematic review found that more than half of COVID-19 survivors experienced PASC 6 months after recovery, with the most common effects being functional mobility impairments, pulmonary abnormalities, and mental health disorders.
Article
Multidisciplinary Sciences
Ziyad Al-Aly et al.
Summary: This study comprehensively describes the post-acute sequelae of COVID-19 using national healthcare databases, finding increased risk of death and use of health resources beyond the first 30 days of illness, as well as incident sequelae in various organ systems, increased use of therapeutic agents, and evidence of laboratory abnormalities. The findings show a risk gradient according to the severity of acute COVID-19 infection and highlight the burden of health loss experienced by patients who survive the acute phase.
Review
Biochemistry & Molecular Biology
Ani Nalbandian et al.
Summary: SARS-CoV-2 is responsible for the COVID-19 pandemic, causing global healthcare crises. Recovery from COVID-19 may lead to persistent symptoms and long-term complications, prompting the need for multidisciplinary care and follow-up for survivors.
Article
Multidisciplinary Sciences
Carole H. Sudre et al.
Summary: Documenting symptom time series in the early days of COVID-19 infection can help predict the need for respiratory support with high accuracy, allowing for the monitoring of at-risk patients and predicting medical resource requirements days in advance.
Article
Biochemistry & Molecular Biology
Narjes Saheb Sharif-Askari et al.
Summary: Severe viral infections, such as SARS-COV-2, can disrupt the balance between pro-oxidant and antioxidant mediators, with oxidative stress genes showing upregulation in COVID-19 patients, particularly in severe cases. The dysregulation of oxidative stress genes correlates with the severity of the disease and more mechanistic studies are needed to confirm this relationship.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Multidisciplinary Sciences
Dominik Menges et al.
Summary: This study found a significant proportion of individuals experiencing longer-term consequences after SARS-CoV-2 infection. Some patients did not fully recover six to eight months post-diagnosis, with many experiencing symptoms of fatigue, dyspnea, or depression. Additionally, a high percentage sought healthcare services after acute illness, but some individuals did not seek further care despite ongoing symptoms.
Article
Cardiac & Cardiovascular Systems
Beatriz Costa Todt et al.
Summary: The study found that COVID-19 patients frequently experience persistent clinical and mental health issues up to 3 months following hospital discharge, significantly impacting their health-related quality of life. Female sex and intensive care requirement were independently associated with worsening of HRQoL.
RESPIRATORY MEDICINE
(2021)
Article
Critical Care Medicine
Davies Adeloye et al.
Summary: An international consensus exercise was conducted to identify research priorities for understanding the long-term effects of acute COVID-19, focusing on individuals with pre-existing airways disease. High priority was given to investigations on prognostic scores at hospital admission and morbidity at 3 months and 12 months after hospital discharge, as well as comparisons of prevalence and severity of post-COVID-19 symptoms between patients with and without pre-existing airways disease.
LANCET RESPIRATORY MEDICINE
(2021)
Review
Medicine, General & Internal
Tahmina Nasserie et al.
Summary: COVID-19 infection is associated with persistent symptoms such as shortness of breath, fatigue, and insomnia. Current studies on symptom persistence are highly heterogeneous, and future research needs longer follow-up, improved quality, and more standardized designs to accurately quantify risks.
Review
Medicine, General & Internal
Fahad M. Iqbal et al.
Summary: This study aimed to investigate the prevalence of clinical characteristics of acute and chronic post-COVID syndrome, finding that fatigue and dyspnoea were the most prevalent symptoms in acute stage, while fatigue and sleep disturbance were the most prevalent symptoms in chronic stage. However, the overall quality of available evidence is poor, with significant risk of bias.
Letter
Medicine, General & Internal
Angelo Carfi et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2020)
Article
Multidisciplinary Sciences
Liam Townsend et al.
Article
Emergency Medicine
Christian R. Timbol et al.
OPEN ACCESS EMERGENCY MEDICINE
(2019)
Article
Psychiatry
Christian Winther Topp et al.
PSYCHOTHERAPY AND PSYCHOSOMATICS
(2015)
Review
Endocrinology & Metabolism
S. T. Ngo et al.
FRONTIERS IN NEUROENDOCRINOLOGY
(2014)
Article
Cardiac & Cardiovascular Systems
Luciana Paladini et al.
RESPIRATORY MEDICINE
(2010)