期刊
FRONTIERS IN NEUROLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fneur.2021.774805
关键词
spaceflight; launch abort; ventricular volume; free water (FW); microgravity; hypergravity
资金
- NASA [NNX11AR02G]
- NSERC postdoctoral fellowship
- NASA Human Research Program augmentation grant
- National Institute on Aging fellowship [1F99AG068440]
- NASA [137931, NNX11AR02G] Funding Source: Federal RePORTER
A case report found that hypergravity exposure during launch and landing did not result in lasting enlargement of the brain's ventricles or intracranial fluid shifts. This suggests that hypergravity may not contribute to the same brain changes as those seen following spaceflight.
Spaceflight induces lasting enlargement of the brain's ventricles as well as intracranial fluid shifts. These intracranial fluid shifts have been attributed to prolonged microgravity exposure, however, the potential effects of hypergravity exposure during launch and landing have yet to be elucidated. Here we describe a case report of a Crewmember who experienced an Aborted Launch (CAL). CAL's launch and landing experience was dissociated from prolonged microgravity exposure. Using MRI, we show that hypergravity exposure during the aborted launch did not induce lasting ventricular enlargement or intracranial fluid shifts resembling those previously reported with spaceflight. This case study therefore rules out hypergravity during launch and landing as a contributing factor to previously reported long-lasting intracranial fluid changes following spaceflight.
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