4.6 Review

Tissue-Resident Macrophages in the Stria Vascularis

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Summary: Recent studies have shown the presence of macrophages and potentially lymphocytes in the human cochlea, indicating both innate and adaptive immune capacity. The rich expression of the fractalkine gene transcripts in spiral ganglion neurons suggests an essential role in auditory nerve protection. These findings highlight the importance of the immune machinery in the human inner ear and its potential to trigger adverse immune reactions, supporting the development of immune-modulating therapies.

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