4.6 Article

Histone Deacetylase Isoforms Differentially Modulate Inflammatory and Autoantibody Responses in a Mouse Model of Myasthenia Gravis

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IL-21 enhances STAT3/Blimp-1 signaling pathway in B cells and contributes to plasma cell differentiation in newly diagnosed patients with myasthenia gravis

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Summary: This study demonstrated for the first time the aberrant expression of Blimp-1 in peripheral blood B cells of MG patients, which was positively correlated with clinical severity score (QMGs), plasma cell frequency, and serum IL-21 levels. Glucocorticoid treatment reduced the expression of Blimp-1 and p-STAT3 in B cells, leading to relieved clinical severity, reduced plasma cell frequency, and decreased serum IL-21 levels. Additionally, IL-21 stimulation upregulated STAT3 phosphorylation and Blimp-1 expression in B cells, promoting plasma cell differentiation, which could be inhibited by dexamethasone or STAT3 inhibitor stattic.

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