4.8 Review

Pushing Past the Blockade: Advancements in T Cell-Based Cancer Immunotherapies

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Immunology

Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion

Nicole E. Scharping et al.

Summary: Continuous TCR signaling and hypoxia increase Blimp-1, suppressing mitochondrial reprogramming and generating reactive oxygen species, leading to T cell exhaustion. Mitigating T cell-intrinsic ROS and reducing tumor hypoxia can limit T cell exhaustion, synergizing with immunotherapy.

NATURE IMMUNOLOGY (2021)

Article Oncology

Peripheral T cell receptor repertoire features predict durable responses to anti-PD-1 inhibitor monotherapy in advanced renal cell carcinoma

Taigo Kato et al.

Summary: In this study, researchers analyzed peripheral blood and tumor tissue samples from patients with advanced kidney cancer before and after PD-1 treatment and found an expansion of specific T cell clones in the peripheral blood of responders post-treatment, indicating a possible correlation with tumor-infiltrating T cells.

ONCOIMMUNOLOGY (2021)

Article Oncology

Rapid Depletion of Intratumoral Regulatory T Cells Induces Synchronized CD8 T- and NK-cell Activation and IFN gamma-Dependent Tumor Vessel Regression

Yutaka Kurebayashi et al.

Summary: Depletion of intratumoral Tregs leads to activation of CD8 T and NK cells, inducing IFN gamma-dependent tumor vessel regression and ischemic tumor necrosis, thereby suppressing tumor growth.

CANCER RESEARCH (2021)

Article Biochemistry & Molecular Biology

Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis

Nathan D. Mathewson et al.

Summary: This study utilized single-cell RNA sequencing to uncover the gene expression and clonal landscape of T cells in diffuse gliomas, identifying potential effectors of anti-tumor immunity. The research revealed that KLRB1 and its associated transcriptional program play an inhibitory role in tumor immunity, and blocking its function enhances T cell killing of glioma cells.
Article Oncology

Fc-Optimized Anti-CCR8 Antibody Depletes Regulatory T Cells in Human Tumor Models

Joseph R. Campbell et al.

Summary: Research suggests that selectively depleting regulatory T cells using an anti-CCR8 antibody can enhance antitumor immune responses, whether used as a monotherapy or in combination with other immunotherapies.

CANCER RESEARCH (2021)

Article Multidisciplinary Sciences

Transient rest restores functionality in exhausted CAR-T cells through epigenetic remodeling

Evan W. Weber et al.

Summary: This study showed that transient cessation of chimeric antigen receptor (CAR) signaling can enhance the efficacy of CAR-T cells, reactivating their anti-tumor functions, and challenging the notion that exhaustion is an epigenetically fixed state.

SCIENCE (2021)

Article Cell Biology

SynNotch CAR circuits enhance solid tumor recognition and promote persistent antitumor activity in mouse models

Axel Hyrenius-Wittsten et al.

Summary: The synthetic Notch (synNotch) CAR circuits improve the specificity and persistent antitumor activity of therapeutic T cells in solid tumors by preventing CAR-mediated tonic signaling, allowing T cells to maintain long-lived memory and non-exhausted phenotype. ALPPL2 is established as a clinically viable cell therapy target for multiple solid tumors, and synNotch CAR T cells demonstrate multifaceted therapeutic benefits.

SCIENCE TRANSLATIONAL MEDICINE (2021)

Article Cell Biology

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma

Joseph H. Choe et al.

Summary: By utilizing circuits that integrate recognition of multiple imperfect but complementary antigens, we have enhanced the specificity, completeness, and persistence of CAR T cells directed against glioblastoma, offering a general recognition strategy applicable to other solid tumors.

SCIENCE TRANSLATIONAL MEDICINE (2021)

Article Multidisciplinary Sciences

Targeting Treg cells with GITR activation alleviates resistance to immunotherapy in murine glioblastomas

Zohreh Amoozgar et al.

Summary: In this study, researchers found that treatment with an agonistic anti-GITR antibody converts tumor infiltrating regulatory T cells to effector cells, overcoming resistance to PD1 blockade in preclinical models of GBM.

NATURE COMMUNICATIONS (2021)

Article Oncology

Targeting CSF1R Alone or in Combination with PD1 in Experimental Glioma

Justyna M. Przystal et al.

Summary: This study investigated treatment strategies that target tumor-associated macrophages in the microenvironment by blocking CSF1R, alone or in combination with PD1 blockade. The results suggest that targeting CSF1R is a promising therapeutic approach for glioblastoma, potentially in conjunction with PD1 inhibition, as shown by increased survival in mouse models and enhanced attack of the immune system in ex vivo microtumor models.

CANCERS (2021)

Review Oncology

CD4 T-Cell Exhaustion: Does It Exist and What Are Its Roles in Cancer?

Alexandra M. Miggelbrink et al.

Summary: In chronic infections and cancer, persistent antigen stimulation can lead to T-cell exhaustion, with CD4 T-cell exhaustion being less studied but potentially clinically relevant in orchestrating immune responses and disease severity. Understanding phenotypic exhaustion in CD4 T cells and its impact on immune responses and disease severity is crucial for identifying novel therapeutic targets in cancer.

CLINICAL CANCER RESEARCH (2021)

Article Oncology

Sequential Phase II clinical trials evaluating CRLX101 as monotherapy and in combination with bevacizumab in recurrent ovarian cancer

Carolyn N. Krasner et al.

Summary: CRLX101, as a novel cyclodextrin-containing polymer conjugate of camptothecin, shows promising efficacy in treating recurrent epithelial ovarian cancer, with good tolerability. When combined with bevacizumab, it can improve clinical benefit rates and overall response rates without severe adverse events.

GYNECOLOGIC ONCOLOGY (2021)

Article Multidisciplinary Sciences

TIM-3 restrains anti-tumour immunity by regulating inflammasome activation

Karen O. Dixon et al.

Summary: Research demonstrates the crucial role of TIM-3 in regulating dendritic cell (DC) function, with TIM-3 deletion promoting strong anti-tumour immunity by preventing DCs from expressing a regulatory program and facilitating the maintenance of CD8(+) effector and stem-like T cells. The absence of TIM-3 in DCs leads to increased accumulation of reactive oxygen species, resulting in NLRP3 inflammasome activation, and inhibition of inflammasome activation or downstream effector cytokines IL-1 beta and IL-18 abrogates the protective anti-tumour immunity observed with TIM-3 deletion in DCs.

NATURE (2021)

Article Immunology

Metabolic reprogramming of terminally exhausted CD8+ T cells by IL-10 enhances anti-tumor immunity

Yugang Guo et al.

Summary: The study demonstrates that a half-life-extended IL-10-Fc fusion protein can enhance the function of terminally exhausted CD8(+) tumor-infiltrating lymphocytes by promoting oxidative phosphorylation, leading to improved response to cancer immunotherapy.

NATURE IMMUNOLOGY (2021)

Article Multidisciplinary Sciences

Combined tumor-directed recruitment and protection from immune suppression enable CAR T cell efficacy in solid tumors

Bruno L. Cadilha et al.

Summary: The study found that redirecting effector T cells to the tumor site using CCR8, coupled with shielding them from TGF-beta using DNR, can enhance the therapeutic efficacy of CAR T cells in solid tumors.

SCIENCE ADVANCES (2021)

Review Immunology

Near-infrared photoimmunotherapy of cancer: a new approach that kills cancer cells and enhances anti-cancer host immunity

Hisataka Kobayashi et al.

Summary: NIR-PIT is a promising cancer therapy that selectively kills cancer cells and activates the immune system, potentially serving as an important treatment modality for cancer patients.

INTERNATIONAL IMMUNOLOGY (2021)

Review Pharmacology & Pharmacy

CAR T-Cell Therapy in Hematologic Malignancies: A Voyage in Progress

Sarah A. Holstein et al.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2020)

Review Biotechnology & Applied Microbiology

CAR T cells and checkpoint inhibition for the treatment of glioblastoma

Steven H. Shen et al.

EXPERT OPINION ON BIOLOGICAL THERAPY (2020)

Article Multidisciplinary Sciences

VEGF-C-driven lymphatic drainage enables immunosurveillance of brain tumours

Eric Song et al.

NATURE (2020)

Article Biochemistry & Molecular Biology

Immune profiling of human tumors identifies CD73 as a combinatorial target in glioblastoma

Sangeeta Goswami et al.

NATURE MEDICINE (2020)

Article Multidisciplinary Sciences

Optimized antiangiogenic reprogramming of the tumor microenvironment potentiates CD40 immunotherapy

Abhishek S. Kashyap et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Multidisciplinary Sciences

CCR2 inhibition reduces tumor myeloid cells and unmasks a checkpoint inhibitor effect to slow progression of resistant murine gliomas

Joseph A. Flores-Toro et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Review Immunology

CD73's Potential as an Immunotherapy Target in Gastrointestinal Cancers

Jerry B. Harvey et al.

FRONTIERS IN IMMUNOLOGY (2020)

Review Oncology

Tim-3 finds its place in the cancer immunotherapy landscape

Nandini Acharya et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2020)

Review Immunology

Targeting CD39 in cancer

Achim K. Moesta et al.

NATURE REVIEWS IMMUNOLOGY (2020)

Article Multidisciplinary Sciences

Depletion of regulatory T cells in tumors with an anti-CD25 immunotoxin induces CD8 T cell-mediated systemic antitumor immunity

Masanori Onda et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Review Oncology

HIF Inhibitors: Status of Current Clinical Development

Jaleh Fallah et al.

CURRENT ONCOLOGY REPORTS (2019)

Article Immunology

CD8 T Cell Exhaustion During Chronic Viral Infection and Cancer

Laura M. McLane et al.

Annual Review of Immunology (2019)

Article Biotechnology & Applied Microbiology

CAR-T cells secreting BiTEs circumvent antigen escape without detectable toxicity

Bryan D. Choi et al.

NATURE BIOTECHNOLOGY (2019)

Review Pharmacology & Pharmacy

Understanding and overcoming the resistance of cancer to PD-1/PD-L1 blockade

Amy L. Shergold et al.

PHARMACOLOGICAL RESEARCH (2019)

Review Biochemistry & Molecular Biology

Neoantigen vaccine: an emerging tumor immunotherapy

Miao Peng et al.

MOLECULAR CANCER (2019)

Article Medicine, General & Internal

Five-Year Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma

J. Larkin et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Review Biotechnology & Applied Microbiology

OX40 (CD 134) and OX40 ligand, important immune checkpoints in cancer

Juan Deng et al.

ONCOTARGETS AND THERAPY (2019)

Article Oncology

Metabolic Consequences of T-cell Costimulation in Anticancer Immunity

Alvaro Teijeira et al.

CANCER IMMUNOLOGY RESEARCH (2019)

Article Biochemistry & Molecular Biology

Fibrinogen-like Protein 1 Is a Major Immune Inhibitory Ligand of LAG-3

Jun Wang et al.

Review Immunology

Selecting costimulatory domains for chimeric antigen receptors: functional and clinical considerations

Robert Weinkove et al.

CLINICAL & TRANSLATIONAL IMMUNOLOGY (2019)

Review Immunology

Macrophages as regulators of tumour immunity and immunotherapy

David G. DeNardo et al.

NATURE REVIEWS IMMUNOLOGY (2019)

Article Oncology

The Immune Revolution: A Case for Priming, Not Checkpoint

Robert H. Vonderheide

CANCER CELL (2018)

Article Oncology

T-Cell Exhaustion Signatures Vary with Tumor Type and Are Severe in Glioblastoma

Karolina Woroniecka et al.

CLINICAL CANCER RESEARCH (2018)

Article Immunology

The Immune Landscape of Cancer

Vesteinn Thorsson et al.

IMMUNITY (2018)

Article Medicine, Research & Experimental

Host expression of PD-L1 determines efficacy of PD-L1 pathway blockade-mediated tumor regression

Heng Lin et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

Article Multidisciplinary Sciences

TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis

Daniele V. F. Tauriello et al.

NATURE (2018)

Article Medicine, General & Internal

Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia

S. L. Maude et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Multidisciplinary Sciences

Macrophages impede CD8 T cells from reaching tumor cells and limit the efficacy of anti-PD-1 treatment

Elisa Peranzoni et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Multidisciplinary Sciences

TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells

Sanjeev Mariathasan et al.

NATURE (2018)

Review Cell Biology

Regulatory T cells in cancer immunotherapy

Atsushi Tanaka et al.

CELL RESEARCH (2017)

Article Multidisciplinary Sciences

CCR8+FOXp3+ Treg cells as master drivers of immune regulation

Yiftah Barsheshet et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Oncology

Pilot trial of CRLX101 in patients with advanced, chemotherapy-refractory gastroesophageal cancer

Joseph Chao et al.

JOURNAL OF GASTROINTESTINAL ONCOLOGY (2017)

Review Oncology

Microenvironmental regulation of tumour angiogenesis

Michele de Palma et al.

NATURE REVIEWS CANCER (2017)

Article Immunology

Transient Treg depletion enhances therapeutic anti-cancer vaccination

Scott A. Fisher et al.

IMMUNITY INFLAMMATION AND DISEASE (2017)

Article Oncology

The Microenvironmental Landscape of Brain Tumors

Daniela F. Quail et al.

CANCER CELL (2017)

Article Biochemistry & Molecular Biology

CD73 regulates anti-inflammatory signaling between apoptotic cells and endotoxin-conditioned tissue macrophages

Patrick S. Murphy et al.

CELL DEATH AND DIFFERENTIATION (2017)

Article Medicine, Research & Experimental

Endothelial cell-derived angiopoietin-2 is a therapeutic target in treatment-naive and bevacizumab-resistant glioblastoma

Alexander Scholz et al.

EMBO MOLECULAR MEDICINE (2016)

Review Immunology

Treg stability: to be or not to be

Abigail E. Overacre et al.

CURRENT OPINION IN IMMUNOLOGY (2016)

Article Multidisciplinary Sciences

Follicular CXCR5-expressing CD8+ T cells curtail chronic viral infection

Ran He et al.

NATURE (2016)

Article Multidisciplinary Sciences

Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy

Se Jin Im et al.

NATURE (2016)

Article Immunology

CXCR5+ follicular cytotoxic T cells control viral infection in B cell follicles

Yew Ann Leong et al.

NATURE IMMUNOLOGY (2016)

Article Multidisciplinary Sciences

The epigenetic landscape of T cell exhaustion

Debattama R. Sen et al.

SCIENCE (2016)

Article Multidisciplinary Sciences

Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade

Kristen E. Pauken et al.

SCIENCE (2016)

Article Biochemistry & Molecular Biology

Catch me if you can: Leukemia Escape after CD19-Directed T Cell Immunotherapies

Marco Ruella et al.

COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2016)

Article Gastroenterology & Hepatology

Exclusion of T Cells From Pancreatic Carcinomas in Mice Is Regulated by Ly6Clow F4/80+ Extratumoral Macrophages

Gregory L. Beatty et al.

GASTROENTEROLOGY (2015)

Review Cell Biology

Brain barriers: Crosstalk between complex tight junctions and adherens junctions

Silvia Tietz et al.

JOURNAL OF CELL BIOLOGY (2015)

Article Biochemistry & Molecular Biology

The prognostic landscape of genes and infiltrating immune cells across human cancers

Andrew J. Gentles et al.

NATURE MEDICINE (2015)

Review Multidisciplinary Sciences

Neoantigens in cancer immunotherapy

Ton N. Schumacher et al.

SCIENCE (2015)

Review Multidisciplinary Sciences

The future of immune checkpoint therapy

Padmanee Sharma et al.

SCIENCE (2015)

Article Immunology

TCR-signaling events in cellular metabolism and specialization

Danielle A. Chisolm et al.

FRONTIERS IN IMMUNOLOGY (2015)

Article Multidisciplinary Sciences

CEACAM1 regulates TIM-3-mediated tolerance and exhaustion

Yu-Hwa Huang et al.

NATURE (2015)

Review Biochemistry & Molecular Biology

4-1BB (CD137), an inducible costimulatory receptor, as a specific target for cancer therapy

Dass S. Vinay et al.

BMB REPORTS (2014)

Article Oncology

A Mechanism of Hypoxia-Mediated Escape from Adaptive Immunity in Cancer Cells

Ivraym B. Barsoum et al.

CANCER RESEARCH (2014)

Review Biotechnology & Applied Microbiology

Phenotypic alterations, clinical impact and therapeutic potential of regulatory T cells in cancer

Belal Chaudhary et al.

EXPERT OPINION ON BIOLOGICAL THERAPY (2014)

Review Immunology

Design and development of therapies using chimeric antigen receptor-expressing T cells

Gianpietro Dotti et al.

IMMUNOLOGICAL REVIEWS (2014)

Article Multidisciplinary Sciences

Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma

Anoop P. Patel et al.

SCIENCE (2014)

Article Multidisciplinary Sciences

Endogenous Antibodies for Tumor Detection

Barrie S. Rich et al.

SCIENTIFIC REPORTS (2014)

Article Oncology

Reversal of NK-Cell Exhaustion in Advanced Melanoma by Tim-3 Blockade

Ines Pires da Silva et al.

CANCER IMMUNOLOGY RESEARCH (2014)

Review Immunology

The TNFRs OX40, 4-1BB, and CD40 as targets for cancer immunotherapy

Amy E. Moran et al.

CURRENT OPINION IN IMMUNOLOGY (2013)

Article Medicine, Research & Experimental

Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function

Madhusudhanan Sukumar et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

Review Multidisciplinary Sciences

The causes and consequences of genetic heterogeneity in cancer evolution

Rebecca A. Burrell et al.

NATURE (2013)

Review Immunology

Innate and adaptive immune cells in the tumor microenvironment

Thomas F. Gajewski et al.

NATURE IMMUNOLOGY (2013)

Article Biochemistry & Molecular Biology

CSF-1R inhibition alters macrophage polarization and blocks glioma progression

Stephanie M. Pyonteck et al.

NATURE MEDICINE (2013)

Article Biochemistry & Molecular Biology

Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells

Nicola Gagliani et al.

NATURE MEDICINE (2013)

Article Multidisciplinary Sciences

Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics

Andrea Sottoriva et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Review Oncology

The Basic Principles of Chimeric Antigen Receptor Design

Michel Sadelain et al.

CANCER DISCOVERY (2013)

Review Biochemistry & Molecular Biology

Hypoxia-inducible factor 1: Regulator of mitochondrial metabolism and mediator of ischemic preconditioning

Gregg L. Semenza

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2011)

Review Immunology

4-1BB signaling beyond T cells

Dass S. Vinay et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2011)

Article Multidisciplinary Sciences

An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor

Christiane A. Opitz et al.

NATURE (2011)

Article Biochemistry & Molecular Biology

T-Cell Activation under Hypoxic Conditions Enhances IFN-gamma Secretion

Jessica Roman et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2010)

Editorial Material Clinical Neurology

Vaccine provides new hope for patients with deadly brain cancer

[Anonymous]

FUTURE NEUROLOGY (2010)

Article Immunology

Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity

Kaori Sakuishi et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2010)

Article Multidisciplinary Sciences

Anti-CD73 antibody therapy inhibits breast tumor growth and metastasis

John Stagg et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Multidisciplinary Sciences

Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection

Hyun-Tak Jin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Review Chemistry, Medicinal

Colony-Stimulating Factor-1 Receptor Inhibitors for the Treatment of Cancer and Inflammatory Disease

Sharmila Patel et al.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2009)

Review Immunology

The significance of OX40 and OX40L to T-cell biology and immune disease

Michael Croft et al.

IMMUNOLOGICAL REVIEWS (2009)

Article Immunology

The Expression and Function of the NKRP1 Receptor Family in C57BL/6 Mice

Jonathan G. Aust et al.

JOURNAL OF IMMUNOLOGY (2009)

Review Immunology

The Role of OX40-Mediated Co-stimulation in T-Cell Activation and Survival

William L. Redmond et al.

CRITICAL REVIEWS IN IMMUNOLOGY (2009)

Review Immunology

PD-1 and its ligands in tolerance and immunity

Mary E. Keir et al.

ANNUAL REVIEW OF IMMUNOLOGY (2008)

Review Clinical Neurology

Perivascular Spaces and the Two Steps to Neuroinflammation

Trevor Owens et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2008)

Article Multidisciplinary Sciences

Selective expansion of a subset of exhausted CD8 T cells by αPD-L1 blockade

Shawn D. Blackburn et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Review Immunology

How regulatory T cells work

Dario A. A. Vignali et al.

NATURE REVIEWS IMMUNOLOGY (2008)

Article Oncology

Role of autophagy in cancer

Robin Mathew et al.

NATURE REVIEWS CANCER (2007)

Article Dermatology

TIM-3 is expressed in melanoma cells and is upregulated in TGF-beta stimulated mast cells

Zoltan Wiener et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2007)

Review Cardiac & Cardiovascular Systems

Phenotypic heterogeneity of the endothelium I. Structure, function, and mechanisms

William C. Aird

CIRCULATION RESEARCH (2007)

Article Multidisciplinary Sciences

A2A adenosine receptor protects tumors from antitumor T cells

Akio Ohta et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Immunology

Cutting edge: Lectin-like transcript 1 is a ligand for the CD161 receptor

H Aldemir et al.

JOURNAL OF IMMUNOLOGY (2005)

Article Neurosciences

Decreased FOXP3 levels in multiple sclerosis patients

J Huan et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2005)

Article Immunology

T cells that cannot respond to TGF-β escape control by CD4+CD25+ regulatory T cells

L Fahlén et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2005)

Article Immunology

Role of LAG-3 in regulatory T cells

CT Huang et al.

IMMUNITY (2004)

Article Medicine, General & Internal

Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer

L Zhang et al.

NEW ENGLAND JOURNAL OF MEDICINE (2003)

Article Biochemistry & Molecular Biology

Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis

M Skobe et al.

NATURE MEDICINE (2001)