期刊
FRONTIERS IN IMMUNOLOGY
卷 13, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2022.833560
关键词
Chagas' disease; Trypanosoma cruzi; fibrosis; immunomodulation; adjuvants; interleukin-10; interferon-gamma; inflammation
类别
资金
- CNPq
- FAPESB
- FAPERJ
- FIOCRUZ
- FOG (Fundacao Octacilio Gualberto)
Administration of alpha-tocopherol before T. cruzi infection can reduce parasitemia and mortality rate in mice, enhance IFN-gamma production by T and NK cells, increase IL-10 production by T and myeloid suppressor cells, and promote the formation of effector memory T cells while decreasing PD-1 expression on T cells.
Chagas disease is accompanied by a multisystem inflammatory disorder that follows Trypanosoma cruzi infection. Alpha-tocopherol has been described as an antioxidant and a potential adjuvant to enhance immune responses to vaccines. Therefore, we have evaluated the immune response to T. cruzi infection upon alpha-tocopherol pre-administration. The results show that administration of alpha-tocopherol before the infection results in lower parasitemia and lower mortality of C57BL/6 mice infected with the Tulahuen T. cruzi strain. Alpha-tocopherol administration in normal C57BL/6 mice resulted in higher levels of IFN-gamma production by T and NK cells before and after the infection with T. cruzi. More importantly, previous administration of alpha-tocopherol increased the production of IL-10 by T and myeloid suppressor cells and the formation of effector memory T cells while decreasing the expression of PD-1 on T cells. These results suggest that alpha-tocopherol may limit the appearance of dysfunctional T cells during the acute and early chronic phases of T. cruzi infection, contributing to control infection. In addition, alpha-tocopherol could diminish tissue inflammation and fibrosis in late acute disease. These results strongly suggest that alpha-tocopherol may be a helpful agent to be considered in Chagas disease.
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