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Regulation of Pattern-Recognition Receptor Signaling by HBX During Hepatitis B Virus Infection

FRONTIERS IN IMMUNOLOGY (2022)

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Hepatitis B virus inhibits intrinsic RIG-I and RIG-G immune signaling via inducing miR146a

Zhaohua Hou et al.

SCIENTIFIC REPORTS (2016)

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Article Cell Biology

Hepatitis B Virus X Protein Promotes Degradation of SMC5/6 to Enhance HBV Replication

Christopher M. Murphy et al.

CELL REPORTS (2016)

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Article Medicine, Research & Experimental

Hepatitis B Virus X and Regulation of Viral Gene Expression

Betty L. Slagle et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2016)

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Article Microbiology

Hepatitis B Virus-Induced Parkin-Dependent Recruitment of Linear Ubiquitin Assembly Complex (LUBAC) to Mitochondria and Attenuation of Innate Immunity

Mohsin Khan et al.

PLOS PATHOGENS (2016)

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Article Biochemistry & Molecular Biology

Innate immune evasion by hepatitis B virus-mediated downregulation of TRIF

Yun Hong et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)

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Article Oncology

Downregulation of toll-like receptor 4 induces suppressive effects on hepatitis B virus-related hepatocellular carcinoma via ERK1/2 signaling

Yiting Wang et al.

BMC CANCER (2015)

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Article Immunology

The RNA Sensor RIG-I Dually Functions as an Innate Sensor and Direct Antiviral Factor for Hepatitis B Virus

Seiichi Sato et al.

IMMUNITY (2015)

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Article Cell Biology

Autophagy Mediates HBx-Induced Nuclear Factor-κB Activation and Release of IL-6, IL-8, and CXCL2 in Hepatocytes

Millore X. M. Luo et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2015)

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Article Gastroenterology & Hepatology

Human hepatitis B virus surface and e antigens inhibit major vault protein signaling in interferon induction pathways

Shi Liu et al.

JOURNAL OF HEPATOLOGY (2015)

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Article Virology

The enhanced expression of death receptor 5 (DR5) mediated by HBV X protein through NF-kappaB pathway is associated with cell apoptosis induced by (TNF-α related apoptosis inducing ligand) TRAIL in hepatoma cells

Fanyun Kong et al.

VIROLOGY JOURNAL (2015)

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Article Virology

Hepatitis B virus X protein increases the IL-1β-induced NF-κB activation via interaction with evolutionarily conserved signaling intermediate in Toll pathways (ECSIT)

Wan-nan Chen et al.

VIRUS RESEARCH (2015)

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Article Gastroenterology & Hepatology

Molecular mechanism of hepatitis B virus X protein function in hepatocarcinogenesis

Ming Geng et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2015)

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Article Cell Biology

Hepatitis B virus hijacks CTHRC1 to evade host immunity and maintain replication

Lan Bai et al.

JOURNAL OF MOLECULAR CELL BIOLOGY (2015)

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Article Virology

Hepatitis B Virus Polymerase Disrupts K63-Linked Ubiquitination of STING To Block Innate Cytosolic DNA-Sensing Pathways

Yinghui Liu et al.

JOURNAL OF VIROLOGY (2015)

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Review Immunology

Toll-like receptor (TLR)-mediated innate immune responses in the control of hepatitis B virus (HBV) infection

Ejuan Zhang et al.

MEDICAL MICROBIOLOGY AND IMMUNOLOGY (2015)

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Article Infectious Diseases

Reduced Toll-like receptor 9 expression on peripheral CD14+ monocytes of chronic hepatitis B patients and its restoration by effective therapy

Yi-Wen Huang et al.

ANTIVIRAL THERAPY (2014)

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Review Pharmacology & Pharmacy

The roles of hepatitis B virus-encoded X protein in virus replication and the pathogenesis of chronic liver disease

Mark A. Feitelson et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2014)

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Article Immunology

Decreased expression of toll like receptor signaling molecules in chronic HBV infected patients

Mohammad Momeni et al.

HUMAN IMMUNOLOGY (2014)

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Article Gastroenterology & Hepatology

Toll-like receptor-mediated immune responses are attenuated in the presence of high levels of hepatitis B virus surface antigen

M. Jiang et al.

JOURNAL OF VIRAL HEPATITIS (2014)

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Article Virology

Downregulation of Interleukin-18-Mediated Cell Signaling and Interferon Gamma Expression by the Hepatitis B Virus e Antigen

S. Jegaskanda et al.

JOURNAL OF VIROLOGY (2014)

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Article Gastroenterology & Hepatology

Control of hepatitis B virus replication by interferons and Toll-like receptor signaling pathways

Rong-Juan Pei et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2014)

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Article Gastroenterology & Hepatology

Hepatitis B virus, HBx mutants and their role in hepatocellular carcinoma

Ashraf Ali et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2014)

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Article Infectious Diseases

Reduced Toll-like receptor 3 expression in chronic hepatitis B patients and its restoration by interferon therapy

Yi-Wen Huang et al.

ANTIVIRAL THERAPY (2013)

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Article Virology

Effects of hepatitis B virus X gene on apoptosis and expression of immune molecules of human proximal tubular epithelial cells

Xuan Wang et al.

ARCHIVES OF VIROLOGY (2013)

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Article Pharmacology & Pharmacy

5′-Triphosphate-siRNA activates RIG-I-dependent type I interferon production and enhances inhibition of hepatitis B virus replication in HepG2.215 cells

Xiaojuan Chen et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2013)

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Article Biochemistry & Molecular Biology

Hepatitis B virus X protein protects hepatoma and hepatic cells from complement-dependent cytotoxicity by up-regulation of CD46

Shuai Zhang et al.

FEBS LETTERS (2013)

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Review Biochemistry & Molecular Biology

Unraveling the complexity of hepatitis B virus: From molecular understanding to therapeutic strategy in 50 years

Bo Liu et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2013)

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Article Medicine, Research & Experimental

Hepatitis B virus X protein modulates apoptosis in human renal proximal tubular epithelial cells by activating the JAK2/STAT3 signaling pathway

Ping He et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2013)

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Article Biochemistry & Molecular Biology

HBx-dependent activation of twist mediates STAT3 control of epithelium-mesenchymal transition of liver cells

Jing Teng et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2013)

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Article Gastroenterology & Hepatology

Hepatitis B virus HBx protein impairs liver regeneration through enhanced expression of IL-6 in transgenic mice

Ivan Quetier et al.

JOURNAL OF HEPATOLOGY (2013)

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Article Multidisciplinary Sciences

HBx-Induced NF-κB Signaling in Liver Cells Is Potentially Mediated by the Ternary Complex of HBx with p22-FLIP and NEMO

Keo-Heun Lim et al.

PLOS ONE (2013)

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Article Multidisciplinary Sciences

Increased Expression of Gp96 by HBx-Induced NF-κB Activation Feedback Enhances Hepatitis B Virus Production

Hongxia Fan et al.

PLOS ONE (2013)

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Article Biochemistry & Molecular Biology

The interaction between hepatitis B virus X protein and AIB1 oncogene is required for the activation of NFκB signal transduction

Andy Hong et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2012)

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Review Cell Biology

Induction of type I IFNs by intracellular DNA-sensing pathways

Taner Cavlar et al.

IMMUNOLOGY AND CELL BIOLOGY (2012)

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Article Cell Biology

Downregulation of TLR7/9 leads to deficient production of IFN-α from plasmacytoid dendritic cells in chronic hepatitis B

Ning Xu et al.

INFLAMMATION RESEARCH (2012)

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Article Medicine, Research & Experimental

Hepatitis B virus X protein inhibits extracellular IFN-α-mediated signal transduction by downregulation of type I IFN receptor

Il-Rae Cho et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2012)

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Article Cell Biology

Hepatitis B virus X protein induces IKKa nuclear translocation via Akt-Dependent phosphorylation to promote the motility of hepatocarcinoma cells

Wei-Chien Huang et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2012)

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Article Immunology

Upregulation of IL-23 Expression in Patients with Chronic Hepatitis B Is Mediated by the HBx/ERK/NF-κB Pathway

Limin Xia et al.

JOURNAL OF IMMUNOLOGY (2012)

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Article Multidisciplinary Sciences

Hepatitis B Virus X Protein Upregulates mTOR Signaling through IKKβ to Increase Cell Proliferation and VEGF Production in Hepatocellular Carcinoma

Chia-Jui Yen et al.

PLOS ONE (2012)

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Article Multidisciplinary Sciences

HBsAg Inhibits IFN-α Production in Plasmacytoid Dendritic Cells through TNF-α and IL-10 Induction in Monocytes

Bisheng Shi et al.

PLOS ONE (2012)

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Article Virology

Hepatitis B virus X protein enhances activation of nuclear factor κB through interaction with valosin-containing protein

Bo-Yan Jiao et al.

ARCHIVES OF VIROLOGY (2011)

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Article Gastroenterology & Hepatology

Reversal of Hepatitis B Virus-Induced Immune Tolerance By an Immunostimulatory 3p-HBx-siRNAs in a Retinoic Acid Inducible Gene I-Dependent Manner

Qiuju Han et al.

HEPATOLOGY (2011)

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Article Gastroenterology & Hepatology

Hepatitis B virus X protein stimulates IL-6 expression in hepatocytes via a MyD88-dependent pathway

Wen-Qing Xiang et al.

JOURNAL OF HEPATOLOGY (2011)

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Article Gastroenterology & Hepatology

The Hepatitis B e antigen (HBeAg) targets and suppresses activation of the Toll-like receptor signaling pathway

Tali Lang et al.

JOURNAL OF HEPATOLOGY (2011)

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Article Gastroenterology & Hepatology

The hepatitis B e antigen suppresses IL-1β-mediated NF-κB activation in hepatocytes

R. Wilson et al.

JOURNAL OF VIRAL HEPATITIS (2011)

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Article Virology

Hepatitis B Virus Regulatory HBx Protein Binds to Adaptor Protein IPS-1 and Inhibits the Activation of Beta Interferon

Manish Kumar et al.

JOURNAL OF VIROLOGY (2011)

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Article Multidisciplinary Sciences

RPS3a Over-Expressed in HBV-Associated Hepatocellular Carcinoma Enhances the HBx-Induced NF-κB Signaling via Its Novel Chaperoning Function

Keo-Heun Lim et al.

PLOS ONE (2011)

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Article Multidisciplinary Sciences

Hepatitis B Virus Impairs TLR9 Expression and Function in Plasmacytoid Dendritic Cells

Isabelle E. Vincent et al.

PLOS ONE (2011)

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Article Multidisciplinary Sciences

Involvement of Activation of PKR in HBx-siRNA-Mediated Innate Immune Effects on HBV Inhibition

Qiuju Han et al.

PLOS ONE (2011)

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Review Biochemistry & Molecular Biology

Pattern Recognition Receptors and Inflammation

Osamu Takeuchi et al.

CELL (2010)

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Article Immunology

Hepatitis B virus X protein suppresses virus-triggered IRF3 activation and IFN-β induction by disrupting the VISA-associated complex

Xianmiao Wang et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2010)

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Article Biochemistry & Molecular Biology

The hepatitis B viral X protein activates NF-κB signaling pathway through the up-regulation of TBK1

Hye Rim Kim et al.

FEBS LETTERS (2010)

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Article Biochemistry & Molecular Biology

Hepatitis B Virus Protein X-induced Expression of the CXC Chemokine IP-10 Is Mediated through Activation of NF-κB and Increases Migration of Leukocytes

Yu Zhou et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

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Article Biotechnology & Applied Microbiology

Hepatitis B virus polymerase inhibits RIG-I- and Toll-like receptor 3-mediated beta interferon induction in human hepatocytes through interference with interferon regulatory factor 3 activation and dampening of the interaction between TBK1/IKKε and DDX3

Shiyan Yu et al.

JOURNAL OF GENERAL VIROLOGY (2010)

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Article Gastroenterology & Hepatology

Lethal-7 is down-regulated by the hepatitis B virus x protein and targets signal transducer and activator of transcription 3

Yu Wang et al.

JOURNAL OF HEPATOLOGY (2010)

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Article Immunology

The Hepatitis B Virus X Protein Disrupts Innate Immunity by Downregulating Mitochondrial Antiviral Signaling Protein

Congwen Wei et al.

JOURNAL OF IMMUNOLOGY (2010)

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Article Virology

Inhibition of Hepatitis B Virus Replication by MyD88 Involves Accelerated Degradation of Pregenomic RNA and Nuclear Retention of Pre-S/S RNAs

Jianhua Li et al.

JOURNAL OF VIROLOGY (2010)

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Article Biochemistry & Molecular Biology

NF-κB signaling mediates the induction of MTA1 by hepatitis B virus transactivator protein HBx

T. M. Bui-Nguyen et al.

ONCOGENE (2010)

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Article Multidisciplinary Sciences

Hepatitis B Virus X Protein Impairs Hepatic Insulin Signaling Through Degradation of IRS1 and Induction of SOCS3

KyeongJin Kim et al.

PLOS ONE (2010)

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Article Virology

Overexpression of Toll-like receptor 2/4 on monocytes modulates the activities of CD4+CD25+ regulatory T cells in chronic hepatitis B virus infection

Ye Zhang et al.

VIROLOGY (2010)

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Article Cell Biology

Mechanism of inhibiting type I interferon induction by hepatitis B virus X protein

Junyi Jiang et al.

PROTEIN & CELL (2010)

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Article Biotechnology & Applied Microbiology

Expression of HBX, an oncoprotein of hepatitis B virus, blocks reoviral oncolysis of hepatocellular carcinoma cells

E-H Park et al.

CANCER GENE THERAPY (2009)

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Article Gastroenterology & Hepatology

Hepatitis B Virus Suppresses Toll-like Receptor-Mediated Innate Immune Responses in Murine Parenchymal and Nonparenchymal Liver Cells

Jun Wu et al.

HEPATOLOGY (2009)

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Article Immunology

Patients with chronic hepatitis B infection display deficiency of plasmacytoid dendritic cells with reduced expression of TLR9

Qing Xie et al.

MICROBES AND INFECTION (2009)

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Article Chemistry, Multidisciplinary

Toll-like receptor 7 and 9 expression in peripheral blood mononuclear cells from patients with chronic hepatitis B and related hepatocellular carcinoma

Ning Xu et al.

ACTA PHARMACOLOGICA SINICA (2008)

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Article Biochemistry & Molecular Biology

Hepatitis B virus X protein enhances NFκB activity through cooperating with VBP1

Sang Yong Kim et al.

BMB REPORTS (2008)

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Review Biochemistry & Molecular Biology

Shared principles in NF-κB signaling

Matthew S. Hayden et al.

CELL (2008)

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Review Immunology

Viral evasion and subversion of pattern-recognition receptor signalling

Andrew G. Bowie et al.

NATURE REVIEWS IMMUNOLOGY (2008)

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Article Biotechnology & Applied Microbiology

Hepatitis B virus polymerase inhibits the interferon-inducible MyD88 promoter by blocking nuclear translocation of Stat 1

Min Wu et al.

JOURNAL OF GENERAL VIROLOGY (2007)

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Article Biochemistry & Molecular Biology

Inhibition of hepatitis B virus replication by MyD88 is mediated by nuclear factor-kappaB activation

Shanshan Lin et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2007)

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Article Gastroenterology & Hepatology

Regulation of toll-like receptor-2 expression in chronic hepatitis B by the precore protein

Kumar Visvanathan et al.

HEPATOLOGY (2007)

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Article Biochemistry & Molecular Biology

The interaction of hepatitis B virus X protein and protein phosphatase type 2 Cα and its effect on IL-6

Ji Su Kim et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)

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Article Oncology

Signal transducers and activators of transcription 5b activation enhances hepatocellular carcinoma aggressiveness through induction of epithelial-mesenchymal transition

Terence K. Lee et al.

CANCER RESEARCH (2006)

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Article Immunology

Reduced expression of toll-like receptor 2 on peripheral monocytes in patients with chronic hepatitis B

Stephen M. Riordan et al.

CLINICAL AND VACCINE IMMUNOLOGY (2006)

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Article Virology

Interferon-inducible MyD88 protein inhibits hepatitis B virus replication

XO Wei et al.

VIROLOGY (2004)

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Article Biochemistry & Molecular Biology

Mitochondrially associated hepatitis B virus X protein constitutively activates transcription factors STAT-3 and NF-κB via oxidative stress

G Waris et al.

MOLECULAR AND CELLULAR BIOLOGY (2001)

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Article Biochemistry & Molecular Biology

Through induction of juxtaposition and tyrosine kinase activity of Jak1, X-gene product of hepatitis B virus stimulates Ras and the transcriptional activation through AP-1, NF-κB, and SRE enhancers

HT Kim et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2001)

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