4.8 Review

New Druggable Targets for Rheumatoid Arthritis Based on Insights From Synovial Biology

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Biotechnology & Applied Microbiology

Kinase inhibition in autoimmunity and inflammation

Ali A. Zarrin et al.

Summary: There are still unmet medical needs in the treatment of autoimmune and inflammatory diseases, despite recent advances in the field. Inhibitors targeting the activity of kinases that regulate production of inflammatory mediators have shown promising progress in drug development.

NATURE REVIEWS DRUG DISCOVERY (2021)

Article Multidisciplinary Sciences

Selective inhibition of the BD2 bromodomain of BET proteins in prostate cancer

Emily J. Faivre et al.

NATURE (2020)

Article Biochemistry & Molecular Biology

Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis

Stefano Alivernini et al.

NATURE MEDICINE (2020)

Article Rheumatology

Risk profiling for a refractory course of rheumatoid arthritis

Manuel Becede et al.

SEMINARS IN ARTHRITIS AND RHEUMATISM (2019)

Article Multidisciplinary Sciences

Distinct fibroblast subsets drive inflammation and damage in arthritis

Adam P. Croft et al.

NATURE (2019)

Article Biochemistry & Molecular Biology

Identification of a Unique Inhibitor-Binding Site on Choline Kinase α

Stefanie L. Kall et al.

BIOCHEMISTRY (2018)

Review Pharmacology & Pharmacy

TPL2 kinase action and control of inflammation

Daqi Xu et al.

PHARMACOLOGICAL RESEARCH (2018)

Article Multidisciplinary Sciences

Comprehensive epigenetic landscape of rheumatoid arthritis fibroblast-like synoviocytes

Rizi Ai et al.

NATURE COMMUNICATIONS (2018)

Article Multidisciplinary Sciences

Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis

Fumitaka Mizoguchi et al.

NATURE COMMUNICATIONS (2018)

Article Multidisciplinary Sciences

Single-cell RNA-seq of rheumatoid arthritis synovial tissue using low-cost microfluidic instrumentation

William Stephenson et al.

NATURE COMMUNICATIONS (2018)

Article Biochemistry & Molecular Biology

Off-target inhibition by active site-targeting SHP2 inhibitors

Ryouhei Tsutsumi et al.

FEBS OPEN BIO (2018)

Article Medicine, General & Internal

Rheumatoid arthritis

Josef S. Smolen et al.

NATURE REVIEWS DISEASE PRIMERS (2018)

Article Biochemistry & Molecular Biology

Hypoxia potentiates monocyte-derived dendritic cells for release of tumor necrosis factor α via MAP3K8

Laurent M. Paardekooper et al.

BIOSCIENCE REPORTS (2018)

Review Rheumatology

Update on the genetic architecture of rheumatoid arthritis

Kwangwoo Kim et al.

NATURE REVIEWS RHEUMATOLOGY (2017)

Review Pharmacology & Pharmacy

PAD4: pathophysiology, current therapeutics and future perspective in rheumatoid arthritis

Sindhu Koushik et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2017)

Article Medicine, Research & Experimental

Two rheumatoid arthritis-specific autoantigens correlate microbial immunity with autoimmune responses in joints

Annalisa Pianta et al.

JOURNAL OF CLINICAL INVESTIGATION (2017)

Article Medicine, General & Internal

Pathogenetic insights from the treatment of rheumatoid arthritis

Iain B. McInnes et al.

LANCET (2017)

Review Rheumatology

Synovial tissue research: a state-of-the-art review

Carl Orr et al.

NATURE REVIEWS RHEUMATOLOGY (2017)

Review Oncology

Therapeutic Targeting of Oncogenic Tyrosine Phosphatases

Rochelle Frankson et al.

CANCER RESEARCH (2017)

Review Rheumatology

Treating rheumatoid arthritis to target: 2014 update of the recommendations of an international task force

Josef S. Smolen et al.

ANNALS OF THE RHEUMATIC DISEASES (2016)

Review Rheumatology

Targeting of proangiogenic signalling pathways in chronic inflammation

Sander W. Tas et al.

NATURE REVIEWS RHEUMATOLOGY (2016)

Article Biochemistry & Molecular Biology

TLR and TNF-R1 activation of the MKK3/MKK6-p38α axis in macrophages is mediated by TPL-2 kinase

Michael J. Pattison et al.

BIOCHEMICAL JOURNAL (2016)

Article Rheumatology

A twin study of rheumatoid arthritis in the Japanese population

Chikashi Terao et al.

MODERN RHEUMATOLOGY (2016)

Article Biochemistry & Molecular Biology

Histone deacetylase 6 structure and molecular basis of catalysis and inhibition

Yang Hai et al.

NATURE CHEMICAL BIOLOGY (2016)

Article Biochemistry & Molecular Biology

The Crystal Structure of Cancer Osaka Thyroid Kinase Reveals an Unexpected Kinase Domain Fold

Sascha Gutmann et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

Article Biochemistry & Molecular Biology

Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation

Huw D. Lewis et al.

NATURE CHEMICAL BIOLOGY (2015)

Article Multidisciplinary Sciences

Genomic modulators of gene expression in human neutrophils

Vivek Naranbhai et al.

NATURE COMMUNICATIONS (2015)

Article Rheumatology

Choline kinase inhibition in rheumatoid arthritis

M. Guma et al.

ANNALS OF THE RHEUMATIC DISEASES (2015)

Article Multidisciplinary Sciences

Genetics of rheumatoid arthritis contributes to biology and drug discovery

Yukinori Okada et al.

NATURE (2014)

Review Multidisciplinary Sciences

Metabolism of stromal and immune cells in health and disease

Bart Ghesquiere et al.

NATURE (2014)

Article Biochemistry & Molecular Biology

Dual kinase-bromodomain inhibitors for rationally designed polypharmacology

Pietro Ciceri et al.

NATURE CHEMICAL BIOLOGY (2014)

Review Rheumatology

Lungs, joints and immunity against citrullinated proteins in rheumatoid arthritis

Anca I. Catrina et al.

NATURE REVIEWS RHEUMATOLOGY (2014)

Article Rheumatology

Synovial phenotypes in rheumatoid arthritis correlate with response to biologic therapeutics

Glynn Dennis et al.

ARTHRITIS RESEARCH & THERAPY (2014)

Review Immunology

Ectopic lymphoid-like structures in infection, cancer and autoimmunity

Costantino Pitzalis et al.

NATURE REVIEWS IMMUNOLOGY (2014)

Article Rheumatology

Forget personalised medicine and focus on abating disease activity

Josef S. Smolen et al.

ANNALS OF THE RHEUMATIC DISEASES (2013)

Article Immunology

Regulation of DNA Methylation in Rheumatoid Arthritis Synoviocytes

Kazuhisa Nakano et al.

JOURNAL OF IMMUNOLOGY (2013)

Article Genetics & Heredity

Chromatin marks identify critical cell types for fine mapping complex trait variants

Gosia Trynka et al.

NATURE GENETICS (2013)

Review Rheumatology

The problem of choice: current biologic agents and future prospects in RA

Ernest H. Choy et al.

NATURE REVIEWS RHEUMATOLOGY (2013)

Review Rheumatology

Pre-rheumatoid arthritis: predisposition and transition to clinical synovitis

William P. Arend et al.

NATURE REVIEWS RHEUMATOLOGY (2012)

Review Oncology

Choline metabolism in malignant transformation

Kristine Glunde et al.

NATURE REVIEWS CANCER (2011)

Review Rheumatology

Treating rheumatoid arthritis to target: recommendations of an international task force

Josef S. Smolen et al.

ANNALS OF THE RHEUMATIC DISEASES (2010)

Article Biochemistry & Molecular Biology

Selective inhibition of choline kinase simultaneously attenuates MAPK and PI3K/AKT signaling

A. Yalcin et al.

ONCOGENE (2010)

Review Medicine, General & Internal

New therapies for treatment of rheumatoid arthritis

Josef S. Smolen et al.

LANCET (2007)

Review Biotechnology & Applied Microbiology

Therapeutic strategies for rheumatoid arthritis

JS Smolen et al.

NATURE REVIEWS DRUG DISCOVERY (2003)