期刊
FRONTIERS IN IMMUNOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2021.783370
关键词
protein tyrosine phosphatases; PTPRO; PTPROt; B cells; T cells; macrophages
类别
资金
- National Natural Science Foundation of China [82072683, 81773087, 81071736, 81572876, 30973508, 81802404]
- Natural Science Foundation of Guangdong Province of China [2021A1515012522, 9151018004000000]
- Science and Technology Planning Project of Guangdong Province of China [2019A030317024]
- Natural Science Foundation of Guangdong Province, China [2021A1515011028, 202110559097]
- Special Project on the Integration of Industry, Education and Research of Guangdong Province [2011A090100024]
- Jinan university Innovation and Entrepreneurship Fund for College Students [2021A1515012522, 202010559081]
PTPRO/PTPROt, as a member of the PTP family, plays a crucial role in immune cells by regulating their growth, differentiation, activation and immune responses. This review focuses on the regulatory roles and molecular mechanisms of PTPRO/PTPROt in B cells, T cells, and macrophages.
The members of the protein tyrosine phosphatase (PTP) family are key regulators in multiple signal transduction pathways and therefore they play important roles in many cellular processes, including immune response. As a member of PTP family, protein tyrosine phosphatase receptor type O (PTPRO) belongs to the R3 receptor-like protein tyrosine phosphatases. The expression of PTPRO isoforms is tissue-specific and the truncated PTPRO (PTPROt) is mainly observed in hematopoietic cells, including B cells, T cells, macrophages and other immune cells. Therefore, PTPROt may play an important role in immune cells by affecting their growth, differentiation, activation and immune responses. In this review, we will focus on the regulatory roles and underlying molecular mechanisms of PTPRO/PTPROt in immune cells, including B cells, T cells, and macrophages.
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