4.8 Article

Serum LAG-3 Predicts Outcome and Treatment Response in Hepatocellular Carcinoma Patients With Transarterial Chemoembolization

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Cell Biology

Transarterial chemoembolisation enhances programmed death-1 and programmed death-ligand 1 expression in hepatocellular carcinoma

Ahmed Montasser et al.

Summary: This study evaluated the impact of transarterial chemoembolization (TACE) on programmed death-1 (PD-1) and programmed death-ligand 1 (PD-L1) expression in surgically treated hepatocellular carcinomas (HCCs). The results showed that TACE treatment led to increased levels of PD-1 and PD-L1 expression in HCCs, supporting the potential use of TACE in combination with immunotherapy to enhance tumor response in selected cases.

HISTOPATHOLOGY (2021)

Review Gastroenterology & Hepatology

Locoregional therapies in the era of molecular and immune treatments for hepatocellular carcinoma

Josep M. Llovet et al.

Summary: Locoregional therapies, including local ablation and transarterial chemoembolization, play a crucial role in the management of hepatocellular carcinoma. Recent studies have shown potential benefits of combining these local therapies with systemic treatments, such as molecular therapies, to enhance therapeutic effects.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2021)

Article Immunology

Changes in the Peripheral Blood Treg Cell Proportion in Hepatocellular Carcinoma Patients After Transarterial Chemoembolization With Microparticles

Zhizhong Ren et al.

Summary: The study demonstrated that m-TACE has a positive regulatory effect on the anticancer immune function of HCC patients and can be used in combination with immune adjuvant therapies to enhance the efficacy of HCC treatment.

FRONTIERS IN IMMUNOLOGY (2021)

Review Biochemistry & Molecular Biology

Understanding LAG-3 Signaling

Luisa Chocarro et al.

Summary: LAG-3 is a cell surface inhibitory receptor that regulates immunity and is considered a potential target for enhancing anti-cancer immune responses. Its mechanisms of action and relationship with other immune checkpoint molecules are still poorly understood.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Oncology

Effects of transarterial chemoembolization on the immunological function of patients with hepatocellular carcinoma

Jingjing Guo et al.

Summary: The study showed that TACE treatment led to a decrease in CD4(+)/CD8(+) cell ratio and an increase in PD1 gene expression in HCC patients. Expression levels of PD1 and PD-L1 were associated with TACE treatment outcomes and patient prognosis.

ONCOLOGY LETTERS (2021)

Article Oncology

Development of a Prognostic Scoring System for Hepatocellular Carcinoma Patients With Main Portal Vein Tumor Thrombus Undergoing Conventional Transarterial Chemoembolization: An Analysis of 173 Patients

Jing-huan Li et al.

Summary: This retrospective study evaluated prognostic stratification of HCC patients with mPVTT and found that c-TACE could provide survival benefits. Based on the results, patients can be divided into different risk groups according to certain factors, which may help to identify suitable candidates for treatment.

FRONTIERS IN ONCOLOGY (2021)

Article Health Care Sciences & Services

The Role of Soluble LAG3 and Soluble Immune Checkpoints Profile in Advanced Head and Neck Cancer: A Pilot Study

Andrea Botticelli et al.

Summary: Through the evaluation of specific soluble immune checkpoints, particularly sLAG3, it can help identify patients with poor prognosis or resistance to treatment, and may lead to the development of novel targeted strategies.

JOURNAL OF PERSONALIZED MEDICINE (2021)

Article Medicine, General & Internal

Atezolizumab plus Bevacizumab in Unresectable Hepatocellular Carcinoma

Richard S. Finn et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Review Medicine, General & Internal

Hepatocellular Carcinoma

Augusto Villanueva

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Article Biochemistry & Molecular Biology

Fibrinogen-like Protein 1 Is a Major Immune Inhibitory Ligand of LAG-3

Jun Wang et al.

Article Biotechnology & Applied Microbiology

sLAG-3 in non-small-cell lung cancer patients' serum

Yayi He et al.

ONCOTARGETS AND THERAPY (2018)

Article Medicine, Research & Experimental

LAG-3 regulates CD8+T cell accumulation and effector function in murine self- and tumor-tolerance systems

Joseph F. Grosso et al.

JOURNAL OF CLINICAL INVESTIGATION (2007)

Article Immunology

Expression of lymphocyte activation gene 3 (LAG-3) on B cells is induced by T cells

M Kisielow et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2005)

Article Immunology

Negative regulation of T cell homeostasisby lymphocyte activation gene-3 (CD223)

CJ Workman et al.

JOURNAL OF IMMUNOLOGY (2005)