期刊
FRONTIERS IN IMMUNOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2021.779881
关键词
acute kidney injury; allogeneic hematologic stem cell transplantation; GvHD; experimental BMT; cytokine; calcinurin inhibitors; thrombotic microagiopathy
类别
资金
- JSPS KAKENHI [JP20K08704, JP21K08410]
- Japanese Society of Hematology Research Grant
- Takeda Science Foundation
- Hope from Harper St. Baldrick's Foundation Fellowship
- Hyundai Hope on Wheels Young Investigator Grant
Acute kidney injury is a common complication of allogeneic hematopoietic cell transplantation and can be caused by multiple factors. Recent studies suggest that graft-versus-host disease may attack the kidneys and contribute to the development of renal injury.
Acute kidney injury (AKI) is a common complication of allogeneic hematopoietic cell transplantation (allo-HCT) and is associated with non-relapse mortality (NRM) and quality of life (QOL). Multiple factors may contribute to AKI during allo-HCT and are often present at the same time making it difficult to determine the cause of AKI in each patient. Nephrotoxic drugs, infections, thrombotic microangiopathy (TMA), and sinusoidal obstruction syndrome (SOS) are well described causes of AKI during allo-HCT. Acute graft-versus-host disease (aGVHD) is a major complication of allo-HCT that mainly targets the intestines, liver, and skin. However, recent studies suggest aGVHD may also attack the kidney and contribute to AKI following allo-HCT. For example, severe aGVHD is associated with AKI, suggesting a link between the two. In addition, animal models have shown donor immune cell infiltration and increased expression of inflammatory cytokines in recipient kidneys after allo-HCT. Therefore, aGVHD may also target the kidney and contribute to AKI following allo-HCT. Herein, we describe the etiology, diagnosis, risk factors, pathophysiology, prevention, and treatment of renal injury after allo-HCT. In addition, we highlight emerging evidence that aGVHD may contribute to the development of AKI after allo-HCT.
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