Histone Acetylation Regulator-Mediated Acetylation Patterns Define Tumor Malignant Pathways and Tumor Microenvironment in Hepatocellular Carcinoma

Article Oncology

Insight into the role of multiple signaling pathways in regulating cancer stem cells of gynecologic cancers

Yizuo Song et al.

Summary: Developmental signaling pathways have been shown to play a critical role in regulating cancer stem cell activity in gynecologic malignancies. Targeting these pathways may enhance treatment outcomes in gynecologic cancers.

SEMINARS IN CANCER BIOLOGY (2022)

添加到收藏夹

Review Oncology

Cytotoxic CD8+T cells in cancer and cancer immunotherapy

Hans Raskov et al.

Summary: The functions and interactions between the innate and adaptive immune systems play a crucial role in anticancer immunity. Cytotoxic T cells with CD8 as the most effective effectors in the anticancer immune response form the basis of successful cancer immunotherapies. Advancements in genetically modified or synthetic receptors on cytotoxic T cells are being developed for future cancer treatment. Combinatory regimens may optimize treatment effects and reduce adverse events in cancer therapy.

BRITISH JOURNAL OF CANCER (2021)

添加到收藏夹

Article Oncology

Camrelizumab in Combination with Apatinib in Patients with Advanced Hepatocellular Carcinoma (RESCUE): A for Nonrandomized, Open-label, Phase II Trial

Jianming Xu et al.

Summary: Camrelizumab combined with apatinib showed promising efficacy and manageable safety in patients with advanced hepatocellular carcinoma, representing a novel treatment option for these patients.

CLINICAL CANCER RESEARCH (2021)

添加到收藏夹

Article Gastroenterology & Hepatology

Notch activity characterizes a common hepatocellular carcinoma subtype with unique molecular and clinicopathologic features

Changyu Zhu et al.

Summary: The study revealed that Notch activity characterizes a distinct molecular subtype of HCC in humans, associated with unique histology and prognosis. Sustained Notch signaling in chronic liver diseases can drive tumor formation without acquiring specific genomic driver mutations.

JOURNAL OF HEPATOLOGY (2021)

添加到收藏夹

Article Medicine, Research & Experimental

A novel immune classification reveals distinct immune escape mechanism and genomic alterations: implications for immunotherapy in hepatocellular carcinoma

Zaoqu Liu et al.

Summary: The study identified three distinct tumor immunological microenvironment (TIME) phenotypes in hepatocellular carcinoma, each with different clinical outcomes, immune escape mechanisms, and genomic alterations. These findings may offer strategies to improve the efficacy of immunotherapy. Time index (TI) was proposed as a novel prognostic and immunotherapeutic signature to guide personalized immunotherapy and clinical management of HCC.

JOURNAL OF TRANSLATIONAL MEDICINE (2021)

添加到收藏夹

Review Chemistry, Medicinal

Direct targeting of β-catenin in the Wnt signaling pathway: Current progress and perspectives

Zhen Wang et al.

Summary: Aberrant activation of the Wnt/beta-catenin signaling pathway is associated with cancer, and direct targeting of beta-catenin is a promising strategy but challenging. Research has identified potential small-molecule binding sites and summarized bioactive small molecules that target beta-catenin directly.

MEDICINAL RESEARCH REVIEWS (2021)

添加到收藏夹

Article Immunology

Tumor suppressor gene mutations correlate with prognosis and immunotherapy benefit in hepatocellular carcinoma

Zaoqu Liu et al.

Summary: The study found that HCC patients with TSG non-mutated tumors are more likely to respond positively to immune checkpoint inhibitors, showing higher levels of immune cell infiltration and immune checkpoint expression, leading to longer overall survival. Therefore, TSG subtypes may serve as promising biomarkers for guiding surveillance protocols and immunotherapeutic decisions in patients with HCC.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

添加到收藏夹

Article Medicine, General & Internal

Hepatocellular carcinoma

Josep M. Llovet et al.

Summary: Liver cancer, particularly hepatocellular carcinoma (HCC), poses a significant global health challenge with rising incidence projected to exceed 1 million cases by 2025. Infection by hepatitis B and C viruses remains a major risk factor for HCC, while non-alcoholic steatohepatitis is emerging as a more common risk factor in Western countries. Advances in systemic therapies for HCC, including immunotherapies and targeted therapies, are expected to revolutionize the management of this disease.

NATURE REVIEWS DISEASE PRIMERS (2021)

添加到收藏夹

Article Oncology

Hypoxia Molecular Characterization in Hepatocellular Carcinoma Identifies One Risk Signature and Two Nomograms for Clinical Management

Zaoqu Liu et al.

Summary: This study identified two hypoxia subtypes with distinct biological and clinical characteristics in hepatocellular carcinoma, enhancing the understanding of hypoxia pattern. Additionally, the developed and validated risk signature HARS showed excellent performance in predicting prognosis and immunotherapy.

JOURNAL OF ONCOLOGY (2021)

添加到收藏夹

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Prominent Role of Histone Modifications in the Regulation of Tumor Metastasis

Mariam Markouli et al.

Summary: Tumor aggressiveness and progression rely heavily on the coordinated interaction of genetic and epigenetic mechanisms during metastasis, involving various steps such as EMT, anoikis resistance, intra- and extravasation, and colonization of new tissues. Epigenetic mechanisms like DNA methylation, histone modifications, and non-coding RNAs play crucial roles in regulating gene expression related to the metastatic phenotype. Active and repressive histone post-translational modifications, along with transcription factors, are key in controlling genes associated with tumor progression.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Article Cell Biology

TTN/OBSCN 'Double-Hit' predicts favourable prognosis, 'immune-hot' subtype and potentially better immunotherapeutic efficacy in colorectal cancer

Zaoqu Liu et al.

Summary: A recent study revealed that CRC patients with TTN/OBSCN 'Double-Hit' phenotype had significantly better prognosis, an 'immune-hot' subtype, and potentially better immunotherapeutic efficacy.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Cross-talk of four types of RNA modification writers defines tumor microenvironment and pharmacogenomic landscape in colorectal cancer

Huifang Chen et al.

Summary: Our study provides a comprehensive analysis of four RNA modifications in CRC and reveals the potential functions of these writers in TME, transcriptional and post-transcriptional events. The study also identifies the therapeutic implications of targeting these writers in cancer therapy, highlighting their potential clinical utility in targeted therapy and immunotherapy.

MOLECULAR CANCER (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Intratumoral heterogeneity in cancer progression and response to immunotherapy

Ilio Vitale et al.

Summary: Tumors evolve under various pressures and exhibit considerable heterogeneity in genetic, phenotypic, and behavioral aspects. This intratumoral heterogeneity influences disease progression and treatment sensitivity, necessitating consideration of multiple levels of heterogeneity in future therapeutic approaches.

NATURE MEDICINE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

RALYL increases hepatocellular carcinoma stemness by sustaining the mRNA stability of TGF-β2

Xia Wang et al.

Summary: Studies have shown that RALYL, a liver progenitor specific gene, regulates HCC stemness by sustaining TGF-beta 2 mRNA stability, which may inspire precise therapeutic strategies for HCC.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Review Cell Biology

Notch Signaling Regulation in HCC: From Hepatitis Virus to Non-Coding RNAs

Catia Giovannini et al.

Summary: Notch signaling pathway plays important roles in HCC, but the deregulated expression of different Notch receptors and ligands and their effects are not fully understood. Although interfering with Notch signaling may be a promising therapeutic approach, the complexity of Notch/ligands interactions and the uncertain consequences of their modulations are concerns. Current research supports the development of alternatives to gamma-secretase pan-inhibitors for HCC therapy.

CELLS (2021)

添加到收藏夹

Article Pharmacology & Pharmacy

Therapeutic Potential of CUDC-907 (Fimepinostat) for Hepatocarcinoma Treatment Revealed by Tumor Spheroids-Based Drug Screening

Wei Liao et al.

Summary: Cancer is the second leading cause of death globally. Traditional drug screening methods often result in unsuccessful clinical trials due to lack of efficacy. In this study, a novel spheroid cell culture device was used to screen anti-hepatocarcinoma drugs, leading to the discovery of CUDC-907 as a potent anti-HCC agent. Further research showed that CUDC-907 inhibits the PI3K/AKT/mTOR pathway and downregulates c-Myc expression, thereby suppressing HCC cells.

FRONTIERS IN PHARMACOLOGY (2021)

添加到收藏夹

Review Oncology

The evolving treatment paradigm of advanced hepatocellular carcinoma: putting all the pieces back together

Antonio D'Alessio et al.

Summary: Recent advancements in treating advanced hepatocellular carcinoma include the combination of atezolizumab and bevacizumab as a new first-line treatment, while nivolumab monotherapy showed no advantage over sorafenib. Different therapeutic strategies in the Chinese population have outperformed sorafenib, and there are ongoing studies on various immunotherapy combinations in large phase 3 trials.

CURRENT OPINION IN ONCOLOGY (2021)

添加到收藏夹

Article Oncology

Computational Recognition and Clinical Verification of TGF-β-Derived miRNA Signature With Potential Implications in Prognosis and Immunotherapy of Intrahepatic Cholangiocarcinoma

Zaoqu Liu et al.

Summary: This study identified 36 TGF-beta-derived miRNAs, of which 9 were significantly correlated with overall survival in ICC patients. A TGF-beta associated miRNA signature (TAMIS) was discovered and validated, proving to be an independent risk indicator for both OS and RFS in ICC. TAMIS showed robust performance in three cohorts and provided important insights for immunotherapies of ICC patients.

FRONTIERS IN ONCOLOGY (2021)

添加到收藏夹

Review Oncology

Histone Acetyltransferases and Stem Cell Identity

Ruicen He et al.

Summary: Gene regulation through histone acetylation plays a crucial role in controlling transcription and maintaining stem cell processes. Histone acetylation influences nucleosome structure, making DNA more accessible for transcription and impacting cell fate and gene expression.

CANCERS (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

OGT regulated O-GlcNAcylation promotes papillary thyroid cancer malignancy via activating YAP

Xiaoyan Li et al.

Summary: The incidence of thyroid cancer is increasing globally, with poor prognosis associated with distant metastases. OGT and YAP play critical roles in papillary thyroid cancer, suggesting potential for targeted therapies.

ONCOGENE (2021)

添加到收藏夹

Review Immunology

Regulatory Effects of Histone Deacetylase Inhibitors on Myeloid-Derived Suppressor Cells

Yudan Cui et al.

Summary: HDACIs are antitumor drugs that enhance gene transcription via epigenetic regulation, with cytotoxic properties against tumor cells. The effects of HDACIs on immunocytes in the tumor microenvironment, specifically MDSCs, are still not fully understood.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹

Article Immunology

Clinical Significance and Inflammatory Landscape of a Novel Recurrence-Associated Immune Signature in Stage II/III Colorectal Cancer

Zaoqu Liu et al.

Summary: The study developed a novel recurrence-associated immune signature (RAIS) to identify high-risk recurrence patients with stage II/III colorectal cancer. The high-risk group showed a higher mutation rate of TP53, while the low-risk group had a more abundant presence of activated CD4+/CD8+ T cells and higher expression of PD-1/PD-L1. The RAIS model was proven to be highly predictive of recurrence and could potentially optimize decision-making in adjuvant chemotherapy and immunotherapy, as well as tailor surveillance protocol for individual patients.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹

Review Immunology

The role of dendritic cells in cancer and anti-tumor immunity

Ariel E. Marciscano et al.

Summary: Dendritic cells play a crucial role in the immune response, particularly in anti-tumor immune responses. Understanding the migration of dendritic cells into tissues and their function in the tumor microenvironment can help improve patient outcomes and develop novel treatments targeting dendritic cells.

SEMINARS IN IMMUNOLOGY (2021)

添加到收藏夹

Article Gastroenterology & Hepatology

Dual Programmed Death Receptor-1 and Vascular Endothelial Growth Factor Receptor-2 Blockade Promotes Vascular Normalization and Enhances Antitumor Immune Responses in Hepatocellular Carcinoma

Kohei Shigeta et al.

HEPATOLOGY (2020)

添加到收藏夹

Review Gastroenterology & Hepatology

Tumour evolution in hepatocellular carcinoma

Amanda J. Craig et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2020)

添加到收藏夹

Review Cell Biology

Cancer Stem Cells: Devil or Savior-Looking behind the Scenes of Immunotherapy Failure

Lorenzo Castagnoli et al.

CELLS (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

m6A regulator-mediated methylation modification patterns and tumor microenvironment infiltration characterization in gastric cancer

Bo Zhang et al.

MOLECULAR CANCER (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Targeting Wnt Signaling for the Treatment of Gastric Cancer

Sarah Koushyar et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

添加到收藏夹

Review Immunology

Role of Epigenetic Modifications in Inhibitory Immune Checkpoints in Cancer Development and Progression

Reem Saleh et al.

FRONTIERS IN IMMUNOLOGY (2020)

添加到收藏夹

Review Oncology

Roles of Histone Deacetylases and Inhibitors in Anticancer Therapy

Flavia Alves Verza et al.

CANCERS (2020)

添加到收藏夹

Review Gastroenterology & Hepatology

Modern therapeutic approaches for the treatment of malignant liver tumours

Henrik Petrowsky et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2020)

添加到收藏夹

Review Immunology

Immune Effects of γδ T Cells in Colorectal Cancer: A Review

Rulan Ma et al.

FRONTIERS IN IMMUNOLOGY (2020)

添加到收藏夹

Article Oncology

HDAC Inhibition Increases HLA Class I Expression in Uveal Melanoma

Zahra Souri et al.

CANCERS (2020)

添加到收藏夹

Review Immunology

Modulation of regulatory T cell function and stability by co-inhibitory receptors

Liliana E. Lucca et al.

NATURE REVIEWS IMMUNOLOGY (2020)

添加到收藏夹

Article Oncology

HDAC3 Inhibition Upregulates PD-L1 Expression in B-Cell Lymphomas and Augments the Efficacy of Anti-PD-L1 Therapy

Siyu Deng et al.

MOLECULAR CANCER THERAPEUTICS (2019)

添加到收藏夹

Article Medicine, General & Internal

Pembrolizumab plus Axitinib versus Sunitinib for Advanced Renal-Cell Carcinoma

Brian I. Rini et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

添加到收藏夹

Review Medicine, General & Internal

Hepatocellular Carcinoma

Augusto Villanueva

NEW ENGLAND JOURNAL OF MEDICINE (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

HAT1 Coordinates Histone Production and Acetylation via H4 Promoter Binding

Joshua J. Gruber et al.

MOLECULAR CELL (2019)

添加到收藏夹

Article Oncology

Five-Year Survival and Correlates Among Patients With Advanced Melanoma, Renal Cell Carcinoma, or Non-Small Cell Lung Cancer Treated With Nivolumab

Suzanne L. Topalian et al.

JAMA ONCOLOGY (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

HDAC7 regulates histone 3 lysine 27 acetylation and transcriptional activity at super-enhancer-associated genes in breast cancer stem cells

Corrado Caslini et al.

ONCOGENE (2019)

添加到收藏夹

Review Cell Biology

Role of the transcriptional coactivators YAP/TAZ in liver cancer

Shihao Zhang et al.

CURRENT OPINION IN CELL BIOLOGY (2019)

添加到收藏夹

Editorial Material Pharmacology & Pharmacy

MDSC; the Most Important Cell You Have Never Heard Of

R. J. Tesi

TRENDS IN PHARMACOLOGICAL SCIENCES (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

Integrative molecular and clinical modeling of clinical outcomes to PD1 blockade in patients with metastatic melanoma

David Liu et al.

NATURE MEDICINE (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials

Yuan Cheng et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

Oncogenic Signaling Pathways in The Cancer Genome Atlas

Francisco Sanchez-Vega et al.

CELL (2018)

添加到收藏夹

Article Immunology

The Immune Landscape of Cancer

Vesteinn Thorsson et al.

IMMUNITY (2018)

添加到收藏夹

Review Medicine, General & Internal

Hepatocellular carcinoma

Alejandro Forner et al.

LANCET (2018)

添加到收藏夹

Article Oncology

Histone deacetylase (HDAC) inhibitor ACY241 enhances anti-tumor activities of antigen-specific central memory cytotoxic T lymphocytes against multiple myeloma and solid tumors

Jooeun Bae et al.

LEUKEMIA (2018)

添加到收藏夹

Review Cell Biology

Contextual determinants of TGFβ action in development, immunity and cancer

Charles J. David et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)

添加到收藏夹

Article Public, Environmental & Occupational Health

Changing cancer survival in China during 2003-15: a pooled analysis of 17 population-based cancer registries

Hongmei Zeng et al.

LANCET GLOBAL HEALTH (2018)

添加到收藏夹

Article Multidisciplinary Sciences

TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells

Sanjeev Mariathasan et al.

NATURE (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response

Peng Jiang et al.

NATURE MEDICINE (2018)

添加到收藏夹

Review Biochemistry & Molecular Biology

A Paradigm Shift in Cancer Immunotherapy: From Enhancement to Normalization

Miguel F. Sanmamed et al.

CELL (2018)

添加到收藏夹

Review Cell Biology

Metabolic regulation of gene expression through histone acylations

Benjamin R. Sabari et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2017)

添加到收藏夹

Article Oncology

CREBBP Inactivation Promotes the Development of HDAC3-Dependent Lymphomas

Yanwen Jiang et al.

CANCER DISCOVERY (2017)

添加到收藏夹

Article Medicine, General & Internal

Atezolizumab versus docetaxel in patients with previously treated non-small-cell lung cancer (OAK): a phase 3, open-label, multicentre randomised controlled trial

Achim Rittmeyer et al.

LANCET (2017)

添加到收藏夹

Review Biochemistry & Molecular Biology

EMT and stemness: flexible processes tuned by alternative splicing in development and cancer progression

Davide Pradella et al.

MOLECULAR CANCER (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade

Dung T. Le et al.

SCIENCE (2017)

添加到收藏夹

Article Cell Biology

Pan-cancer Immunogenomic Analyses Reveal Genotype-Immunophenotype Relationships and Predictors of Response to Checkpoint Blockade

Pornpimol Charoentong et al.

CELL REPORTS (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Epigenetic priming restores the HLA class-I antigen processing machinery expression in Merkel cell carcinoma

Cathrin Ritter et al.

SCIENTIFIC REPORTS (2017)

添加到收藏夹

Article Oncology

A Patient-Derived, Pan-Cancer EMT Signature Identifies Global Molecular Alterations and Immune Target Enrichment Following Epithelial-to-Mesenchymal Transition

Milena P. Mak et al.

CLINICAL CANCER RESEARCH (2016)

添加到收藏夹

Review Pathology

Cancer Stem Cells: Basic Concepts and Therapeutic Implications

Dany Nassar et al.

ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 11 (2016)

添加到收藏夹

Article Oncology

HDAC Inhibitors Enhance T-Cell Chemokine Expression and Augment Response to PD-1 Immunotherapy in Lung Adenocarcinoma

Hong Zheng et al.

CLINICAL CANCER RESEARCH (2016)

添加到收藏夹

Article Oncology

Combined nivolumab and ipilimumab versus ipilimumab alone in patients with advanced melanoma: 2-year overall survival outcomes in a multicentre, randomised, controlled, phase 2 trial

F. Stephen Hodi et al.

LANCET ONCOLOGY (2016)

添加到收藏夹

Article Medicine, General & Internal

PD-1 Blockade with Pembrolizumab in Advanced Merkel-Cell Carcinoma

Paul T. Nghiem et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

添加到收藏夹

Review Pharmacology & Pharmacy

Cancer stem cells and chemoresistance: The smartest survives the raid

Jihe Zhao

PHARMACOLOGY & THERAPEUTICS (2016)

添加到收藏夹

Article Medicine, Research & Experimental

HDACs and HDAC Inhibitors in Cancer Development and Therapy

Yixuan Li et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2016)

添加到收藏夹

Article Medicine, General & Internal

Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma

J. Larkin et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

添加到收藏夹

Article Biochemistry & Molecular Biology

limma powers differential expression analyses for RNA-sequencing and microarray studies

Matthew E. Ritchie et al.

NUCLEIC ACIDS RESEARCH (2015)

添加到收藏夹

Article Oncology

HDAC Inhibition Upregulates PD-1 Ligands in Melanoma and Augments Immunotherapy with PD-1 Blockade

David M. Woods et al.

CANCER IMMUNOLOGY RESEARCH (2015)

添加到收藏夹

Article Medicine, General & Internal

Melanoma

Dirk Schadendorf et al.

NATURE REVIEWS DISEASE PRIMERS (2015)

添加到收藏夹

Review Medicine, Research & Experimental

New and emerging HDAC inhibitors for cancer treatment

Alison C. West et al.

JOURNAL OF CLINICAL INVESTIGATION (2014)

添加到收藏夹

Article Oncology

The histone deacetylase inhibitor, LBH589, promotes the systemic cytokine and effector responses of adoptively transferred CD8+ T cells

Dominique N. Lisiero et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2014)

添加到收藏夹

Article Biochemical Research Methods

GSVA: gene set variation analysis for microarray and RNA-Seq data

Sonja Haenzelmann et al.

BMC BIOINFORMATICS (2013)

添加到收藏夹

Article Immunology

Spatiotemporal Dynamics of Intratumoral Immune Cells Reveal the Immune Landscape in Human Cancer

Gabriela Bindea et al.

IMMUNITY (2013)

添加到收藏夹

Article Biochemistry & Molecular Biology

Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells

Wanjuan Yang et al.

NUCLEIC ACIDS RESEARCH (2013)

添加到收藏夹

Article Biochemical Research Methods

The sva package for removing batch effects and other unwanted variation in high-throughput experiments

Jeffrey T. Leek et al.

BIOINFORMATICS (2012)

添加到收藏夹

Article Biotechnology & Applied Microbiology

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

Guangchuang Yu et al.

OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY (2012)

添加到收藏夹

Article Biology

Measurement of mRNA abundance using RNA-seq data: RPKM measure is inconsistent among samples

Gunter P. Wagner et al.

THEORY IN BIOSCIENCES (2012)

添加到收藏夹

Article Oncology

Cancer stem cells: an evolving concept

Long V. Nguyen et al.

NATURE REVIEWS CANCER (2012)

添加到收藏夹

Article Hematology

HDAC11 plays an essential role in regulating OX40 ligand expression in Hodgkin lymphoma

Daniela Buglio et al.

BLOOD (2011)

添加到收藏夹

Article Immunology

Intratumor T helper type 2 cell infiltrate correlates with cancer-associated fibroblast thymic stromal lymphopoietin production and reduced survival in pancreatic cancer

Lucia De Monte et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2011)

添加到收藏夹

Article Multidisciplinary Sciences

Eradication of solid tumors using histone deacetylase inhibitors combined with immune-stimulating antibodies

Ailsa J. Christiansen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

添加到收藏夹

Article Biochemical Research Methods

ConsensusClusterPlus: a class discovery tool with confidence assessments and item tracking

Matthew D. Wilkerson et al.

BIOINFORMATICS (2010)

添加到收藏夹

Review Biochemistry & Molecular Biology

Cancer stem cells - old concepts, new insights

L. Vermeulen et al.

CELL DEATH AND DIFFERENTIATION (2008)

添加到收藏夹

Article Oncology

Histone deacetylase inhibitors induce TAP, LMP, Tapasin genes and MHC class I antigen presentation by melanoma cells

A. Nazmul H. Khan et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2008)

添加到收藏夹

Article Hematology

NKG2D ligand expression in AML increases in response to HDAC inhibitor valproic acid and contributes to allorecognition by NK-cell lines with single KIR-HLA class I specificities

Stefan Diermayr et al.

BLOOD (2008)

添加到收藏夹

Article Urology & Nephrology

Down-regulation of HILA class I antigens in prostate cancer tissues and up-regulation by histone deacetylase inhibition

Hiroshi Kitamura et al.

JOURNAL OF UROLOGY (2007)

添加到收藏夹

Article Oncology

Gene expression profiling in breast cancer: Understanding the molecular basis of histologic grade to improve prognosis

C Sotiriou et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2006)

添加到收藏夹

Histone Acetylation Regulator-Mediated Acetylation Patterns Define Tumor Malignant Pathways and Tumor Microenvironment in Hepatocellular Carcinoma

相关参考文献

导出引文

分享论文