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N Casares et al.
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Y Okabe et al.
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T Kawai et al.
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M Yoneyama et al.
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GP Dunn et al.
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T Tanaka et al.
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F Heil et al.
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A Krug et al.
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M Yoneyama et al.
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S Pestka et al.
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D Gabrilovich
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LA Loeb et al.
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