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Epigenetic Modifications in Tumor-Associated Macrophages: A New Perspective for an Old Foe

期刊

FRONTIERS IN IMMUNOLOGY
卷 13, 期 -, 页码 -

出版社

FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2022.836223

关键词

epigenetic modification; tumor associated macrophage (TAM); histone modification; tumor microenvironment; methylation; acetylation; chromatin remodeling; lncRNA

资金

  1. Natural Science Foundation of Zhejiang Province [LR21H160001, LY21H160025]
  2. Leading Goose R&D Program of Zhejiang Province [2021C03G2153004]
  3. National Natural Science Foundation of China [81802338, 82072646, 81903143]
  4. Start-up Grant of HZNU [4125C5021820470]
  5. Research Project of Jinan Microecological Biomedicine Shandong Laboratory [JNL-2022029C]
  6. Pioneer R&D Program of Zhejiang Province [2021C03G2153004]

向作者/读者索取更多资源

Tumorigenesis often involves chronic inflammation and the tumor microenvironment (TME) consists of various cells and extracellular components. Tumor cells and other cells undergo genetic and epigenetic alterations in the TME, with macrophages being the most plastic immune cell type and playing a crucial role in these alterations.
Tumorigenesis is frequently accompanied by chronic inflammation, and the tumor microenvironment (TME) can be considered an ecosystem that consists of tumor cells, endotheliocytes, fibroblasts, immune cells and acellular components such as extracellular matrix. For tumor cells, their survival advantages are dependent on both genetic and epigenetic alterations, while other cells mainly present epigenetic modifications. Macrophages are the most plastic type of immune cells and undergo diverse epigenetic alterations in the TME. Some of these epigenetic modifications mitigate against cancer progression, and others accelerate this process. Due to the complex roles of macrophages in the TME, it is urgent to understand their epigenetic modifications associated with the TME. Here, we mainly summarize recent findings on TME-associated epigenetic alterations of tumor-associated macrophages (TAMs), including DNA methylation, posttranslational modifications of histone proteins, chromatin remodeling, and noncoding RNA-mediated epigenetic regulation. At the end of this review, we also discuss the translational potential of these epigenetic modifications for developing novel cancer therapies targeting TAMs.

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