期刊
FRONTIERS IN IMMUNOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2021.740632
关键词
intracerebral hemorrhage; perihematomal edema; neuroinflammation; pathophysiology; therapies
类别
资金
- National Natural Science Foundation of China [82001389]
- Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Science [2020-I2M-CT-B-031]
- CAMS/PUMC Postgraduate Teaching Innovation Fund [10023201900107]
- National Key R&D Program of China [2018YFA0108600]
- Huazhong University of Science and Technology Union Shenzhen Hospital Fund [NS202001]
- [2020-I2M-C]
- [T-B-031]
PHE is considered a promising therapeutic target for ICH, but existing research results are conflicting. Therefore, it is necessary to classify, compare, and summarize existing studies on PHE.
Intracerebral hemorrhage (ICH) has one of the worst prognoses among patients with stroke. Surgical measures have been adopted to relieve the mass effect of the hematoma, and developing targeted therapy against secondary brain injury (SBI) after ICH is equally essential. Numerous preclinical and clinical studies have demonstrated that perihematomal edema (PHE) is a quantifiable marker of SBI after ICH and is associated with a poor prognosis. Thus, PHE has been considered a promising therapeutic target for ICH. However, the findings derived from existing studies on PHE are disparate and unclear. Therefore, it is necessary to classify, compare, and summarize the existing studies on PHE. In this review, we describe the growth characteristics and relevant underlying mechanism of PHE, analyze the contributions of different risk factors to PHE, present the potential impact of PHE on patient outcomes, and discuss the currently available therapeutic strategies.
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