期刊
FRONTIERS IN IMMUNOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2021.816499
关键词
NK cells; multiple myeloma; inhibitory receptors; activating receptors; immunotherapy; microenvironment; niche
类别
资金
- project Cell Coolab Ostrava--Research and Development Center for Cell Therapy in Hematology and Oncology [CZ.02.1.01/0.0/0.0/17_049/0008440]
- European Regional Development Fund-Project ENOCH [CZ. 02.1.01/0.0/0.0/16_019/0000868, SGS15/PrF/2021]
NK cells are a subset of lymphocytes that have cytotoxic and suppressor activity against virus-infected cells and cancer cells. They have potential in targeted immunotherapy for solid and hematological malignancies, including multiple myeloma. However, NK cells are impaired by various cancer defense mechanisms, leading to deficiencies in maturation, chemotaxis, target recognition, and killing.
Natural killer (NK) cells represent a subset of CD3- CD7+ CD56+/dim lymphocytes with cytotoxic and suppressor activity against virus-infected cells and cancer cells. The overall potential of NK cells has brought them to the spotlight of targeted immunotherapy in solid and hematological malignancies, including multiple myeloma (MM). Nonetheless, NK cells are subjected to a variety of cancer defense mechanisms, leading to impaired maturation, chemotaxis, target recognition, and killing. This review aims to summarize the available and most current knowledge about cancer-related impairment of NK cell function occurring in MM.
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