期刊
FRONTIERS IN IMMUNOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2021.759679
关键词
Parkinson's disease; pain; nociceptor neurons; neuro-immunity; microbiota; dysbiosis; gut-brain axis
类别
资金
- Canada Research Chair program [950-231859]
- Canadian Institutes of Health Research [162211, 461274, 461275]
- Canadian Foundation for Innovation [37439]
- Natural Sciences and Engineering Research Council of Canada [RGPIN-2019-06824]
- Fonds de recherche du Quebec - Sante
- Centre interdisciplinaire de recherche sur le cerveau et l'apprentissage (CIRCA)
- Fonds de recherche du Quebec - Nature et technologies (FRQNT) [289949]
- Fonds de recherche en ophtalmologie - Universite de Montreal (FROUM)
- Faculty of Medicine of the Universite de Montreal
- CIRCA
Parkinson's disease is the second most common neurodegenerative disorder, with both motor and non-motor symptoms. Dysbiosis in the gut microbiota is linked to the severity of PD symptoms and somatosensory hypersensitivity, highlighting the importance of gut immunity in PD.
Parkinson's disease (PD) is the second most common neurodegenerative disorder, affecting 1-2% of the population aged 65 and over. Additionally, non-motor symptoms such as pain and gastrointestinal dysregulation are also common in PD. These impairments might stem from a dysregulation within the gut-brain axis that alters immunity and the inflammatory state and subsequently drives neurodegeneration. There is increasing evidence linking gut dysbiosis to the severity of PD's motor symptoms as well as to somatosensory hypersensitivities. Altogether, these interdependent features highlight the urgency of reviewing the links between the onset of PD's non-motor symptoms and gut immunity and whether such interplays drive the progression of PD. This review will shed light on maladaptive neuro-immune crosstalk in the context of gut dysbiosis and will posit that such deleterious interplays lead to PD-induced pain hypersensitivity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据