期刊
FRONTIERS IN IMMUNOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2021.803247
关键词
NSCLC; radioimmunotherapy; irradiated organs; inflammatory blood indexes; immune activation effect
类别
资金
- National Key Research and Development Projects of China [2018YFC1312201]
- Foundation of National Natural Science Foundation of China [81972863, 81627901, 82030082]
- National Natural Science Foundation of China [81972864]
- Academic Promotion Program of Shandong First Medical University [2019RC002]
- Science and Technology Support Plan for Youth Innovation Teams of Universities in Shandong Province [2019KJL001]
- Medical Science and Technology Project of Henan Province [SB201901112]
This study suggests that irradiation to the brain has the best immune activation effect and patient outcome compared to other organs in NSCLC. Additionally, combining earlier-line ICIs with RT results in better patient outcomes. Prospective studies are needed to provide more convincing evidence and standards for clinical irradiation metastases selection.
PurposeConsidering the limited data, we aimed to identify the greatest immune activation irradiated site of common metastases and response to immune checkpoint inhibitors simultaneously in non-small cell lung cancer (NSCLC). MethodsA total of 136 patients with advanced NSCLC who had received radiation to a primary or metastatic solid tumor were enrolled. We recorded blood cell counts in three time periods, before, during, and after radiotherapy (RT), and derived some blood index ratios including monocyte-to-lymphocyte ratio (MLR), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII). The delta-IBs were calculated as medio-IBs divided by pre-IBs - 1. We analyzed the changes before and during RT using Spearman rank correlation test, Kruskal-Wallis rank sum test, and logistic regression analyzing their correlation with efficacy. ResultsThe medians of delta-MLR and delta-PLR were both the lowest while the median of delta-L was the highest in brain. Therapeutic effect evaluation showed that the objective response rate (ORR) of 48.65% (18/37) in the brain irradiation group was the highest, compared with 17.07% (7/41) in bone and 41.94% (13/31) in lung. ConclusionsIn this study, results suggested that irradiation to brain has the best immune activation effect and patient outcome compared with other organs in NSCLC, and when the earlier-line ICIs were combined with RT, a better patient outcome was reached. Prospective studies are also necessary to provide more convincing evidence and standards for clinical irradiation metastases selection.
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