期刊
FRONTIERS IN IMMUNOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2021.758154
关键词
COVID-19; vitamin D; HVDRR; adaptive immunity; SARS-CoV-2
类别
资金
- Danish Council for Independent Research [8020-00066B]
- Carlsberg Foundation [CF20-0045]
- Novo Nordisk Foundation [NFF205A0063505, NNF20SA0064201]
The COVID-19 pandemic has had a significant impact worldwide, leading to increased interest in measures to combat the virus, including the role of vitamin D. Recent studies suggest an inverse relationship between plasma vitamin D levels and susceptibility to SARS-CoV-2. However, a study of a family with a mutated vitamin D receptor has questioned the central role of vitamin D in generating an adaptive immune response against SARS-CoV-2.
The coronavirus disease 2019 (COVID-19) pandemic has severely impacted daily life all over the world. Any measures to slow down the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and to decrease disease severity are highly requested. Recent studies have reported inverse correlations between plasma levels of vitamin D and susceptibility to SARS-CoV-2 infection and COVID-19 severity. Therefore, it has been proposed to supplement the general population with vitamin D to reduce the impact of COVID-19. However, by studying the course of COVID-19 and the immune response against SARS-CoV-2 in a family with a mutated, non-functional vitamin D receptor, we here demonstrate that vitamin D signaling was dispensable for mounting an efficient adaptive immune response against SARS-CoV-2 in this family. Although these observations might not directly be transferred to the general population, they question a central role of vitamin D in the generation of adaptive immunity against SARS-CoV-2.
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