Evaluation of the Molecular Mechanisms of Sepsis Using Proteomics

Sepsis is a complex syndrome promoted by pathogenic and host factors; it is characterized by dysregulated host responses and multiple organ dysfunction, which can lead to death. However, its underlying molecular mechanisms remain unknown. Proteomics, as a biotechnology research area in the post-genomic era, paves the way for large-scale protein characterization. With the rapid development of proteomics technology, various approaches can be used to monitor proteome changes and identify differentially expressed proteins in sepsis, which may help to understand the pathophysiological process of sepsis. Although previous reports have summarized proteomics-related data on the diagnosis of sepsis and sepsis-related biomarkers, the present review aims to comprehensively summarize the available literature concerning sepsis, proteomics, cecal ligation and puncture, lipopolysaccharide, and post-translational modifications in relation to proteomics research to provide novel insights into the molecular mechanisms of sepsis.

Automated summary

Sepsis is a complex syndrome characterized by dysregulated host responses and multiple organ dysfunction, with underlying molecular mechanisms remaining unknown. Proteomics technology can help monitor proteome changes and identify differentially expressed proteins in sepsis, providing insights into the pathophysiological process of sepsis. This review aims to comprehensively summarize available literature on sepsis, proteomics, and related factors to offer novel perspectives on the molecular mechanisms of sepsis.