期刊
FRONTIERS IN IMMUNOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2021.787116
关键词
NK cells; macrophages; dendritic cells; chemokine receptors; tumor microenvironment; immunotherapy
类别
资金
- Italian Association for Cancer. Research [AIRC IG-20776, AIRC 5X1000 21147]
- Italian Ministry for University and Research [Prin 20177J4E75, 2017NTK4HY]
- Regione LAZIO Progetto Gruppi di Ricerca [85-2017-15012 B81G18000840005]
NK cells, as innate lymphoid cells, play key roles in immune surveillance of tumors with cytotoxic capacity. Increasing evidence shows that NK cell anti-tumor response is influenced by bidirectional interactions with myeloid cell subsets such as dendritic cells and macrophages in the tumor microenvironment. This crosstalk can impact NK cell survival, activation, differentiation, and function, ultimately affecting the efficacy of immunotherapeutic approaches for cancer.
NK cells are innate lymphoid cells endowed with cytotoxic capacity that play key roles in the immune surveillance of tumors. Increasing evidence indicates that NK cell anti-tumor response is shaped by bidirectional interactions with myeloid cell subsets such as dendritic cells (DCs) and macrophages. DC-NK cell crosstalk in the tumor microenvironment (TME) strongly impacts on the overall NK cell anti-tumor response as DCs can affect NK cell survival and optimal activation while, in turn, NK cells can stimulate DCs survival, maturation and tumor infiltration through the release of soluble factors. Similarly, macrophages can either shape NK cell differentiation and function by expressing activating receptor ligands and/or cytokines, or they can contribute to the establishment of an immune-suppressive microenvironment through the expression and secretion of molecules that ultimately lead to NK cell inhibition. Consequently, the exploitation of NK cell interaction with DCs or macrophages in the tumor context may result in an improvement of efficacy of immunotherapeutic approaches.
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