Regulatory Role of Non-Coding RNAs on Immune Responses During Sepsis

Article Biochemistry & Molecular Biology

LncRNA GAS5 upregulates miR-214 through methylation to participate in cell apoptosis of sepsis

Min Li et al.

Summary: Research has shown that GAS5 can upregulate the expression of miR-214 through methylation pathway, thereby inhibiting cardiomyocyte apoptosis in sepsis.

ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY (2022)

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Article Immunology

LncRNA CASC2 Alleviates Sepsis-induced Acute Lung Injury by Regulating the miR-152-3p/PDK4 Axis

Lili Zhu et al.

Summary: The study revealed that CASC2 alleviated the sepsis-induced acute lung injury by modulating the miR-152-3p/PDK4 pathway. CASC2 exhibited a protective effect on cell viability, apoptosis, inflammation, and oxidative damage in HPAEpiC.

IMMUNOLOGICAL INVESTIGATIONS (2022)

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Article Cell Biology

Exosomes Derived from ADSCs Attenuate Sepsis-Induced Lung Injury by Delivery of Circ-Fryl and Regulation of the miR-490-3p/SIRT3 Pathway

Weijun Shen et al.

Summary: The study demonstrates that circ-Fryl in ADSC exosomes plays a crucial role in alleviating sepsis-induced lung injury by modulating the miR-490-3p/SIRT3 signaling pathway. Furthermore, downregulation of circ-Fryl can suppress the protective effects of ADSC exosomes.

INFLAMMATION (2022)

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Article Medicine, Research & Experimental

Long non-coding RNA XIST alleviates sepsis-induced acute kidney injury through inhibiting inflammation and cell apoptosis via regulating miR-155-5p/WWC1 axis

Lei Wang et al.

Summary: The study found that miR-155-5p was significantly upregulated in sepsis-induced AKI, and inhibiting miR-155-5p could alleviate kidney injury in mice. WWC1 was identified as a direct target of miR-155-5p, with a role in inhibiting inflammatory cytokine production and apoptosis. XIST negatively regulated miR-155-5p expression and positively regulated WWC1 expression, with miR-155-5p overexpression reversing XIST's suppressive effects on inflammation and apoptosis.

KAOHSIUNG JOURNAL OF MEDICAL SCIENCES (2022)

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Article Biotechnology & Applied Microbiology

LncRNA-ROR/microRNA-185-3p/YAP1 axis exerts function in biological characteristics of osteosarcoma cells

Weiguo Wang et al.

Summary: This study demonstrates that down-regulation of lncRNA-ROR or up-regulation of miR-185-3p inhibits osteosarcoma progression through the repression of YAP1.

GENOMICS (2021)

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Article Cell Biology

LncRNA XIST silencing protects against sepsis-induced acute liver injury via inhibition of BRD4 expression

Conglin Shen et al.

Summary: The study found that XIST plays a crucial role in sepsis-induced acute liver injury, with its knockdown ameliorating liver injury and inhibiting inflammation, oxidative stress, and cell apoptosis. The mechanism of XIST's action may be through regulating BRD4.

INFLAMMATION (2021)

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Article Cell Biology

LncRNA H19 Inhibits the Progression of Sepsis-Induced Myocardial InjuryviaRegulation of the miR-93-5p/SORBS2 Axis

Bin Shan et al.

Summary: H19 suppresses sepsis-induced myocardial injury by regulating the miR-93-5p/SORBS2 axis.

INFLAMMATION (2021)

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Article Medicine, Research & Experimental

Exosomal miR-21 secreted by IL-1β-primed-mesenchymal stem cells induces macrophage M2 polarization and ameliorates sepsis

Mengying Yao et al.

Summary: This study characterized the effects of miR-21 delivered by exosomes from MSCs on macrophage polarization in a mouse sepsis model. Beta MSC-derived exosomes induced M2-like polarization of macrophages more effectively, improving survival rates in septic mice. Exosomal miR-21 was identified as a key mediator of the immunomodulatory properties of MSCs induced by IL-1 beta pretreatment, providing a potential therapeutic basis for sepsis.

LIFE SCIENCES (2021)

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Article Medicine, Research & Experimental

Sepsis plasma-derived exosomal miR-1-3p induces endothelial cell dysfunction by targeting SERP1

Min Gao et al.

Summary: The study investigated the effect of miR-1-3p on endothelial cells during sepsis, finding that miR-1-3p inhibits cell proliferation, promotes apoptosis and cytoskeleton contraction by targeting SERP1, leading to dysfunction of endothelial cells and weakening vascular barrier function. MiR-1-3p and SERP1 may be promising therapeutic candidates for sepsis-induced lung injury.

CLINICAL SCIENCE (2021)

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Article Immunology

Inhibition of miR-155 alleviates sepsis-induced inflammation and intestinal barrier dysfunction by inactivating NF-κB signaling

Ying-Ya Cao et al.

Summary: The study found that the miR-155 inhibitor alleviates sepsis-induced inflammation and intestinal barrier dysfunction by inactivating NF-kappa B signaling pathway.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

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Article Medicine, Research & Experimental

Inhibition of miR-101-3p protects against sepsis-induced myocardial injury by inhibiting MAPK and NF-κB pathway activation via the upregulation of DUSP1

Ye Xin et al.

Summary: The inhibition of miR-101-3p exerts cardioprotective effects by enhancing DUSP1 expression, suppressing the activation of the MAPK p38 and NF-kappa B pathways, and thereby mitigating sepsis-induced myocardial injury.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2021)

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Article Medical Laboratory Technology

Association of circulating long non-coding RNA HULC expression with disease risk, inflammatory cytokines, biochemical index levels, severity-assessed scores, and mortality of sepsis

Haiyan Wang et al.

Summary: The study found that lncRNA HULC expression was increased in sepsis patients and positively correlated with disease severity, inflammation, and increased mortality risk, indicating its potential value in predicting disease outcomes.

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2021)

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Article Medicine, Research & Experimental

MicroRNA-150 affects endoplasmic reticulum stress via MALAT1-miR-150 axis-mediated NF-κB pathway in LPS-challenged HUVECs and septic mice

Liang Liu et al.

Summary: The study revealed that miR-150 regulates sepsis-induced endothelial injury by modulating ER stress and inflammation through MALAT1-mediated NF-kappa B pathway.

LIFE SCIENCES (2021)

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Article Cell Biology

lncRNA SNHG14 Plays a Role in Sepsis-Induced Acute Kidney Injury by Regulating miR-93

Chuanchuan Shi et al.

Summary: In this study, it was revealed that SNHG14 accelerates cellular injury in sepsis-induced AKI by activating the IRAK4/NF-kappa B and IL-6R/STAT3 signaling pathways via miR-93.

MEDIATORS OF INFLAMMATION (2021)

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Article Immunology

Molecular pathways in sepsis-induced cardiomyocyte pyroptosis: Novel finding on long non-coding RNA ZFAS1/miR-138-5p/SESN2 axis

Li An et al.

Summary: The study shows that ZFAS1 can alleviate sepsis-induced cardiomyocyte pyroptosis by regulating the expression of miR-138-5p and SESN2.

IMMUNOLOGY LETTERS (2021)

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Article Endocrinology & Metabolism

Knockdown of circ-FANCA alleviates LPS-induced HK2 cell injury via targeting miR-93-5p/OXSR1 axis in septic acute kidney injury

Heyun Li et al.

Summary: The study elucidated the role of circ-FANCA in sepsis-induced AKI by regulating miR-93-5p and OXSR1 expression, which in turn affected cell damage, inflammation, and oxidative stress.

DIABETOLOGY & METABOLIC SYNDROME (2021)

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Article Cell & Tissue Engineering

microRNA-27b shuttled by mesenchymal stem cell-derived exosomes prevents sepsis by targeting JMJD3 and downregulating NF-κB signaling pathway

Jia Sun et al.

Summary: The study revealed that miR-27b highly expressed in exosomes derived from MSCs decreased the expression of pro-inflammatory genes by inhibiting the recruitment of JMJD3 and NF-kappa B, thereby reducing the production of pro-inflammatory cytokines in septic mice and LPS-treated BMDMs.

STEM CELL RESEARCH & THERAPY (2021)

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Article Biochemistry & Molecular Biology

Circular RNA circ_0068,888 protects against lipopolysaccharide-induced HK-2 cell injury via sponging microRNA-21-5p

Wei Wei et al.

Summary: This study revealed the protective effect of hsa_circ_0068,888 on sepsis-associated acute kidney injury by sponging miR-21-5p. Therefore, up-regulation of hsa_circ_0068,888 might be a potential strategy in the treatment of AKI.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

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Article Biochemistry & Molecular Biology

Long non-coding RNA GAS5 aggravates myocardial depression in mice with sepsis via the microRNA-449b/HMGB1 axis and the NF-KB signaling pathway

Hongfeng Gao et al.

Summary: The study investigated the role of lncRNA GAS5 in sepsis-induced myocardial depression in mice. It was found that GAS5 inhibition reduced myocardial depression, injury, and inflammation responses in septic mice. GAS5 was identified to promote sepsis-induced myocardial depression via the miR-449b/HMGB1 axis and NF-KB activation.

BIOSCIENCE REPORTS (2021)

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Article Immunology

Circular RNA circ_0003420 mediates inflammation in sepsis-induced liver damage by downregulating neuronal PAS domain protein 4

Huawei Xiong et al.

Summary: The study revealed that circ_0003420 targets NPAS4 mRNA to mediate cell damage and inflammation induced by LPS. Silencing of circ_0003420 can counteract the effects of LPS on cell proliferation, apoptosis, and inflammatory signs. This provides a potential target for treating liver damage induced by sepsis.

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY (2021)

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Article Cell Biology

LncRNA HOTAIR Promotes LPS-Induced Inflammation and Apoptosis of Cardiomyocytes via Lin28-Mediated PDCD4 Stability

Shu-Yuan Ni et al.

Summary: The study revealed that HOTAIR promotes inflammation and cell apoptosis in septic cardiomyopathy by enhancing PDCD4 stability. The experiments demonstrated that Lin28, a highly conserved RNA-binding protein, interacts with both HOTAIR and PDCD4. Knockdown of HOTAIR alleviated cardiac function injury and inflammatory factor secretion induced by sepsis.

INFLAMMATION (2021)

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Article Cell Biology

LncRNA NEAT1 Promotes Inflammatory Response in Sepsis via the miR-31-5p/POU2F1 Axis

Yang Yang et al.

Summary: NEAT1 inhibits the progression of sepsis induced by LPS in RAW264.7 cells by modulating the miR-31-5p/POU2F1 axis, suggesting NEAT1 as a potential therapeutic target for sepsis.

INFLAMMATION (2021)

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Article Pharmacology & Pharmacy

被撤回的出版物: LncRNA NEAT1 acts as a key regulator of cell apoptosis and inflammatory response by the miR-944/TRIM37 axis in acute lung injury (Retracted article. See vol. 149, pg. 172, 2022)

Cheng Chen et al.

Summary: The study revealed the important role of TRIM37 in ALI, involving in regulating inflammatory response and cell apoptosis through the NF-κB pathway. In addition, miR-944 and NEAT1 also play crucial roles in this process.

JOURNAL OF PHARMACOLOGICAL SCIENCES (2021)

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Article Oncology

lncRNA PVT1 modulates NLRP3-mediated pyroptosis in septic acute kidney injury by targeting miR-20a-5p

Long-Tian Deng et al.

Summary: This study demonstrated the mechanism of PVT1 in regulating pyroptosis in septic AKI, suggesting potential therapeutic targets for septic AKI.

MOLECULAR MEDICINE REPORTS (2021)

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Article Biochemistry & Molecular Biology

Long non-coding RNA SNHG14 aggravates LPS-induced acute kidney injury through regulating miR-495-3p/HIPK1

Ni Yang et al.

Summary: Long non-coding RNA SNHG14 is highly expressed in sepsis patients with AKI and negatively regulates miR-495-3p in HK-2 cells, impacting cell proliferation, apoptosis, autophagy, and inflammatory cytokine production. SNHG14/miR-495-3p/HIPK1 axis modulates the NF-kappa B/p65 signaling pathway to regulate the production of inflammatory cytokines in LPS-challenged HK-2 cells, providing a potential therapeutic target for sepsis-induced AKI.

ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2021)

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Article Biochemistry & Molecular Biology

Circular RNA circVMA21 ameliorates lipopolysaccharide (LPS)-induced acute kidney injury by targeting the miR-199a-5p/NRP1 axis in sepsis

Ximei Li et al.

Summary: The study revealed that circVMA21 plays a crucial regulatory role in sepsis, with its overexpression alleviating LPS-induced cell injury. Mechanical analysis showed that circVMA21 modulates NRP1 expression by sponging miR-199a-5p.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

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Article Medicine, Research & Experimental

Long noncoding plasmacytoma variant translocation 1 facilitates the surveillance of acute respiratory distress syndrome and mortality prediction in sepsis

Yijue Liu et al.

Summary: The study found that lncRNA PVT1 is associated with predicting risk of ARDS and mortality in sepsis patients as an independent factor, and its expression is positively correlated with disease severity.

BIOMARKERS IN MEDICINE (2021)

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Article Immunology

Circular RNA circFADS2 is overexpressed in sepsis and suppresses LPS-induced lung cell apoptosis by inhibiting the maturation of miR-15a-5p

Xiaoyang Hong et al.

Summary: circFADS2 is upregulated in sepsis and suppresses LPS-induced lung cell apoptosis by inhibiting miR-15a-5p maturation.

BMC IMMUNOLOGY (2021)

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Article Cell Biology

Circ_0114428 Regulates Sepsis-Induced Kidney Injury by Targeting the miR-495-3p/CRBN Axis

Yan He et al.

Summary: This study demonstrates that circ_0114428 attenuates sepsis-induced kidney injury in HK2 cells by regulating CRBN expression through targeting miR-495-3p, providing new insights into the mechanisms of kidney injury.

INFLAMMATION (2021)

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Article Medicine, Research & Experimental

Effects of circular RNA Ttc3/miR-148a/Rcan2 axis on inflammation and oxidative stress in rats with acute kidney injury induced by sepsis

Xu Ma et al.

Summary: Research findings demonstrate that CIRC-Ttc3 plays a regulatory role in sepsis-induced AKI by negatively influencing the miR-148a/Rcan2 axis, relieving inflammation and oxidative stress. This suggests that CIRC-Ttc3 may be a potential therapeutic target for sepsis-induced AKI.

LIFE SCIENCES (2021)

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Article Immunology

Long non-coding RNA NEAT1 promotes lipopolysaccharide-induced injury in human tubule epithelial cells by regulating miR-93-5p/TXNIP axis

Jing Yang et al.

Summary: NEAT1 plays a role in sepsis-induced AKI by regulating the miR-93-5p/TXNIP axis and participating in cell injury, potentially providing a new therapeutic strategy for sepsis-associated AKI.

MEDICAL MICROBIOLOGY AND IMMUNOLOGY (2021)

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Article Biochemistry & Molecular Biology

MicroRNA 181a-2-3p Alleviates the Apoptosis of Renal Tubular Epithelial Cells via Targeting GJB2 in Sepsis-Induced Acute Kidney Injury

Hui-xing Yi et al.

Summary: miR-181a-2-3p alleviates the inflammatory response and cell apoptosis of septic patients and animal models by upregulating GJB2 expression.

MOLECULAR AND CELLULAR BIOLOGY (2021)

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Article Biochemistry & Molecular Biology

CircPTK2-miR-181c-5p-HMGB1: a new regulatory pathway for microglia activation and hippocampal neuronal apoptosis induced by sepsis

Min Li et al.

Summary: The study demonstrates the regulatory relationship between circPTK2, miR-181c-5p, and HMGB1 in microglia and sepsis mice. HMGB1 and circPTK2 were upregulated, while miR-181c-5p was downregulated in response to LPS induction in microglia. Targeting circPTK2/miR-181c-5p/HMGB1 signaling pathway may offer potential therapeutic targets for sepsis-induced cognitive dysfunction and neuronal apoptosis.

MOLECULAR MEDICINE (2021)

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Article Oncology

LncRNA NR024118 is downregulated in sepsis and inhibits LPS-induced apoptosis of cardiomyocytes

Gang Qin et al.

Summary: The study showed that lncRNA-NR024118 is downregulated in sepsis patients and is associated with increased levels of IL-6. Patients with sepsis and myocardial dysfunction had even lower NR024118 expression and higher IL-6 levels, which were inversely correlated. Functional studies demonstrated that NR024118 negatively regulated p65 phosphorylation and NF-kappa B activation, suppressing sepsis and inhibiting LPS-induced apoptosis of cardiomyocytes.

MOLECULAR MEDICINE REPORTS (2021)

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Article Oncology

lncRNA GAS5-mediated miR-23a-3p promotes inflammation and cell apoptosis by targeting TLR4 in a cell model of sepsis

Zhenping Gao et al.

Summary: This study identified that GAS5 upregulation enhances LPS-induced inflammation and apoptosis, with GAS5 and TLR4 targeting miR-23a-3p directly. Downregulation of miR-23a-3p and upregulation of TLR4 were observed in septic cells. Overexpression of TLR4 attenuated the suppressive effects of miR-23a-3p and GAS5 knockdown on LPS-induced inflammation and apoptosis.

MOLECULAR MEDICINE REPORTS (2021)

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Article Cell Biology

Down-regulation of long non-coding RNA XIST aggravates sepsis-induced lung injury by regulating miR-16-5p

Xiaofei Song et al.

Summary: This study demonstrates that XIST reduces sepsis-induced acute lung injury by regulating miR-16-5p, as evidenced by the downregulation of XIST promoting pulmonary edema, increasing inflammatory cytokines levels, and inhibiting cell viability. The experimental results confirm the interaction between XIST and miR-16-5p, as well as the reversing effects of miR-16-5p mimics in the cell model.

HUMAN CELL (2021)

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Article Biotechnology & Applied Microbiology

Downregulation of miR-497-5p Improves Sepsis-Induced Acute Lung Injury by Targeting IL2RB

Wei Lou et al.

Summary: The study demonstrated that downregulation of miR-497-5p reduced ALI induced by sepsis through targeting IL2RB, suggesting the potential of miR-497-5p in improving sepsis-induced ALI.

BIOMED RESEARCH INTERNATIONAL (2021)

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Article Physiology

Long Non-coding RNA MEG3 Promotes Renal Tubular Epithelial Cell Pyroptosis by Regulating the miR-18a-3p/GSDMD Pathway in Lipopolysaccharide-Induced Acute Kidney Injury

Junhui Deng et al.

Summary: Our study demonstrates that lncRNA MEG3 promotes renal tubular epithelial pyroptosis by regulating the miR-18a-3p/GSDMD pathway in LPS-induced AKI.

FRONTIERS IN PHYSIOLOGY (2021)

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Article Immunology

lncRNA Mirt2 upregulates miR-1246 through methylation to suppress LPS-induced lung cell apoptosis

Xuwen Xu et al.

Summary: This study revealed that Mirt2 expression was downregulated in sepsis and further decreased in patients with sepsis-ALI. Mirt2 may upregulate miR-1246 through methylation to suppress lung cell apoptosis.

IMMUNITY INFLAMMATION AND DISEASE (2021)

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Article Biochemistry & Molecular Biology

LncRNA NKILA knockdown promotes cell viability and represses cell apoptosis, autophagy and inflammation in lipopolysaccharide-induced sepsis model by regulating miR-140-5p/CLDN2 axis

Dan Han et al.

Summary: The study demonstrates the important role of lncRNA NKILA in sepsis-induced AKI and shows that its silencing can protect cells from LPS-induced damage by reducing CLDN2 levels.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

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Article Medicine, Research & Experimental

LncRNA NEAT1 correlates with Th1 and Th17 and could serve as an assistant biomarker in sepsis

Bo Liu et al.

Summary: The study found that lncRNA NEAT1 is positively correlated with Th1 and Th17 cell proportions in sepsis patients, and is associated with disease severity and prognosis.

BIOMARKERS IN MEDICINE (2021)

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Article Medicine, Research & Experimental

Hyperoside prevents sepsis-associated cardiac dysfunction through regulating cardiomyocyte viability and inflammation via inhibiting miR-21

Jun Zhang et al.

Summary: The study demonstrated that Hyp could alleviate impaired cardiac function and inflammation in sepsis-induced models, as well as decrease in cell viability and increase in inflammation in LPS-induced cardiomyocytes. Hyp significantly inhibited miR-21 expression in LPS-induced cardiomyocytes, and the protective influence of Hyp against sepsis-induced cardiac dysfunction was attenuated by miR-21 upregulation. These findings suggest that Hyp may serve as a promising natural drug for treating sepsis-associated cardiac dysfunction by regulating cardiomyocyte viability and inflammation through suppressing miR-21.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Article Biochemistry & Molecular Biology

Knockdown of lncRNA PVT1 attenuated macrophage M1 polarization and relieved sepsis induced myocardial injury via miR-29a/HMGB1 axis

Yuan-Yuan Luo et al.

Summary: The study revealed that PVT1 expression was elevated in myocardial tissue and heart infiltrating macrophages of sepsis mice. By targeting miR-29a, PVT1 promoted M1 polarization and aggravated LPS induced myocardial injury.

CYTOKINE (2021)

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Article Biochemistry & Molecular Biology

lncRNA MIR155HG Accelerates the Progression of Sepsis via Upregulating MEF2A by Sponging miR-194-5p

Chao Zhang et al.

Summary: This study demonstrates that MIR155HG promotes sepsis progression by modulating the miR-194-5p/MEF2A axis. Knockdown of MIR155HG improves cell viability, reduces apoptosis and inflammation, which can be counteracted by upregulating miR-194-5p. Additionally, overexpression of MEF2A reverses the inhibitory effect on sepsis progression induced by MIR155HG deletion.

DNA AND CELL BIOLOGY (2021)

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Article Cell Biology

CircANKRD36 Knockdown Suppressed Cell Viability and Migration of LPS-Stimulated RAW264.7 Cells by Sponging MiR-330

Qiqing Lin et al.

Summary: The study found that circANKRD36 expression was significantly elevated in the serum of patients with sepsis-induced ARDS. Knockdown of circANKRD36 inhibited cell viability and migration, alleviating inflammation in LPS-stimulated RAW264.7 cells. This suggests that circANKRD36 may play a role in the pathogenesis of sepsis-induced ARDS.

INFLAMMATION (2021)

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Article Biochemistry & Molecular Biology

Long non-coding RNA ZFAS1 alleviates sepsis-induced myocardial injury via target miR-34b-5p/SIRT1

Dan-Dan Chen et al.

Summary: ZFAS1 and SIRT1 were found to be down-regulated, while miR-34b-5p was up-regulated in LPS-induced H9C2 cells. Inhibition of miR-34b-5p or overexpression of ZFAS1 alleviated inflammatory response and cell apoptosis in LPS-stimulated H9C2 cells, suggesting potential therapeutic targets for SIC.

INNATE IMMUNITY (2021)

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Article Immunology

Mesenchymal stem cells-derived extracellular vesicles carrying microRNA-17 inhibits macrophage apoptosis in lipopolysaccharide-induced sepsis

Yuan Su et al.

Summary: The research demonstrates that BMSC-EVs carrying miR-17 can fundamentally inhibit LPS-induced macrophage inflammation by regulating the BRD4-mediated EZH2/TRAIL axis.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

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Article Immunology

被撤回的出版物: LncRNA NEAT1 inhibition upregulates miR-16-5p to restrain the progression of sepsis-induced lung injury via suppressing BRD4 in a mouse model (Retracted article. See vol. 117, 2023)

Jianhong Yin et al.

Summary: NEAT1 inhibition upregulates miR-16-5p to repress the progression of sepsis-induced lung injury via downregulating BRD4. NEAT1 and BRD4 were upregulated while miR-16-5p was downregulated in sepsis-induced lung injury. Inhibition of NEAT1 or elevation of miR-16-5p suppressed pulmonary edema, MPO activity, pathological changes, inflammation and apoptosis, and promoted cell viability in mouse lung tissues.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

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Article Biophysics

Linc-KIAA1737-2 promoted LPS-induced HK-2 cell apoptosis by regulating miR-27a-3p/TLR4/NF-κB axis

Ming Hu et al.

Summary: In this study, upregulation of Linc-KIAA1737-2 was found to promote LPS-induced apoptosis in HK-2 cells, while transfection with miR-27a-3p mimic could attenuate LPS-induced cell apoptosis. These findings suggest a potential role for Linc-KIAA1737-2 in sepsis-induced acute kidney injury through the regulation of the miR-27a-3p/TLR4/NF-kappa B axis.

JOURNAL OF BIOENERGETICS AND BIOMEMBRANES (2021)

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Article Cardiac & Cardiovascular Systems

Circ-PRKCI Alleviates Lipopolysaccharide-induced Human Kidney 2 Cell Injury by Regulating miR-106b-5p/GAB1 Axis

Yueli Xiong et al.

Summary: Circular RNA protein kinase C iota (circ-PRKCI) levels were decreased in sepsis patients and LPS-induced HK-2 cells. Circ-PRKCI positively regulated GAB1 expression by sponging miR-106b-5p, relieving LPS-mediated HK-2 cell damage. Inhibition of miR-106b-5p ameliorated LPS-induced injury in HK-2 cells, while GAB1 knockdown reversed this effect. Overall, overexpression of circ-PRKCI attenuated LPS-induced HK-2 cell injury by regulating the miR-106b-5p/GAB1 axis.

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2021)

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Article Immunology

Macrophage-Derived MicroRNA-21 Drives Overwhelming Glycolytic and Inflammatory Response during Sepsis via Repression of the PGE2/IL-10 Axis

Paulo De Melo et al.

Summary: This study found that the expression of miR-21 in myeloid cells plays a critical role in sepsis, with deletion of miR-21 gene enhancing animal survival, reducing systemic inflammation, and decreasing organ damage. Resistance to sepsis in miR-21(Delta myel) mice is associated with a reduction in aerobic glycolysis and an increase in anti-inflammatory mediators such as PGE(2) and IL-10. Increased survival and decreased systemic inflammation in septic miR-21(Delta myel) mice depend on PGE(2)/IL-10-mediated inhibition of glycolysis.

JOURNAL OF IMMUNOLOGY (2021)

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Article Cell Biology

Circ_0091702 serves as a sponge of miR-545-3p to attenuate sepsis-related acute kidney injury by upregulating THBS2

Mingming Tan et al.

Summary: The study revealed that circ_0091702 may suppress LPS-induced HK2 cell injury via the miR-545-3p/THBS2 axis, suggesting it might be an important biomarker for alleviating sepsis-related AKI.

JOURNAL OF MOLECULAR HISTOLOGY (2021)

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Article Surgery

Long Non-Coding RNA CASC2 Overexpression Ameliorates Sepsis-Associated Acute Kidney Injury by Regulating MiR-545-3p/PPARA Axis

Qionghua Hu et al.

Summary: The study identified that CASC2 plays a protective role in sepsis-induced AKI by regulating the miR-545-3p/PPARA axis. There is a reciprocal regulatory relationship between miR-545-3p and CASC2/PPARA, which affects cellular damage.

JOURNAL OF SURGICAL RESEARCH (2021)

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Article Medicine, Research & Experimental

MicroRNA-150 inhibits myeloid-derived suppressor cells proliferation and function through negative regulation of ARG-1 in sepsis

Qinxin Liu et al.

Summary: The study revealed that miR-150 is down-regulated during sepsis, replenishing miR-150 can reduce the immunosuppression function of MDSCs by down-regulating ARG1 in late sepsis, and has impacts on both pro-inflammatory and anti-inflammatory cytokines. In humans, the level of miR-150 is associated with health and different inflammatory states.

LIFE SCIENCES (2021)

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Article Biochemistry & Molecular Biology

Knockdown of lncRNA LUCAT1 attenuates sepsis-induced myocardial cell injury by sponging miR-642a

Jing Wang et al.

Summary: This study aimed to evaluate the impact of miR-642a on sepsis-induced cardiac injury and found that miR-642a expression was decreased in septic patients and LPS-induced H9C2 cells. Additionally, the miR-642a mimic promoted cell viability and migration, and inhibited cell apoptosis in LPS-induced H9C2 cells. Bioinformatics analysis revealed that miR-642a directly targets the 3'-UTR of ROCK1, and lncRNA LUCAT1 acts as a ceRNA for miR-642a to regulate ROCK1 expression in LPS-induced H9C2 cells, ultimately suppressing sepsis-induced cardiac injury in vitro.

MAMMALIAN GENOME (2021)

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Article Cell Biology

Inhibition of miR-1298-5p attenuates sepsis lung injury by targeting SOCS6

Jian Ma et al.

Summary: Sepsis is a major cause of morbidity and mortality, with acute lung injury being a significant complication. Research on exosomal miRNAs in sepsis and sepsis lung injury is limited, but a study found that miR-1298-5p in exosomes from sepsis lung injury patients targeted SOCS6 via the STAT3 pathway, leading to increased cell permeability and inflammation.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2021)

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Article Oncology

miR-214 ameliorates sepsis-induced acute kidney injury via PTEN/AKT/mTOR-regulated autophagy

Zhenzhen Sang et al.

Summary: The study demonstrated that miR-214 alleviated AKI in septic mice by inhibiting kidney autophagy levels. miR-214 further inhibited autophagy by silencing PTEN expression in the kidney tissues of septic mice. These results suggest that miR-214 ameliorated CLP-induced AKI by reducing oxidative stress and inhibiting autophagy through the regulation of the PTEN/AKT/mTOR pathway.

MOLECULAR MEDICINE REPORTS (2021)

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Article Multidisciplinary Sciences

Exosomal hsa_circRNA_104484 and hsa_circRNA_104670 may serve as potential novel biomarkers and therapeutic targets for sepsis

Chang Tian et al.

Summary: The study identified potential diagnostic markers for sepsis by analyzing the differential expression of circRNAs in serum exosomes, with hsa_circRNA_104484 and hsa_circRNA_104670 showing promise as novel diagnostic biomarkers.

SCIENTIFIC REPORTS (2021)

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Article Respiratory System

Long non-coding RNA CDKN2B-AS1 enhances LPS-induced apoptotic and inflammatory damages in human lung epithelial cells via regulating the miR-140-5p/TGFBR2/Smad3 signal network

Bing Wang et al.

Summary: The study found that CDKN2B-AS1 was abnormally upregulated in sepsis patients and knockdown of CDKN2B-AS1 or TGFBR2 promoted cell growth while inhibiting cell apoptosis and inflammatory response in LPS-treated BEAS-2B cells. Additionally, CDKN2B-AS1 was identified as a miR-140-5p sponge and regulated the TGFBR2/Smad3 pathway by sponging miR-140-5p, contributing to LPS-mediated apoptosis and inflammation in BEAS-2B cells.

BMC PULMONARY MEDICINE (2021)

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Article Respiratory System

Down-regulation of SNHG16 alleviates the acute lung injury in sepsis rats through miR-128-3p/HMGB3 axis

Junli Sun et al.

Summary: Long noncoding RNA SNHG16 plays a role in sepsis-induced acute lung injury by regulating the miR-128-3p/HMGB3 pathway. Upregulation of SNHG16 and HMGB3, along with downregulation of miR-128-3p, exacerbates inflammation and apoptosis in sepsis-induced ALI. Inhibiting SNHG16 can alleviate ALI by modulating the miR-128-3p/HMGB3 axis.

BMC PULMONARY MEDICINE (2021)

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Article Biochemistry & Molecular Biology

Circular RNA TLK1 Promotes Sepsis-Associated Acute Kidney Injury by Regulating Inflammation and Oxidative Stress Through miR-106a-5p/HMGB1 Axis

Hai-Ping Xu et al.

Summary: This study identified a novel circRNA circTLK1 in the regulation of sepsis-induced AKI, showing its role in promoting kidney injury by regulating inflammation and oxidative stress. CircTLK1 enhances HMGB1 expression by sponging miR-106a-5p, which is critical for the injury of LPS-treated cells.

FRONTIERS IN MOLECULAR BIOSCIENCES (2021)

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Article Health Care Sciences & Services

Silencing of LncRNA-PVT1 ameliorates lipopolysaccharide-induced inflammation in THP-1-derived macrophages via inhibition of the p38 MAPK signaling pathway

Shengcai Zheng et al.

Summary: The study demonstrated that lncRNA-PVT1 plays a crucial role in the inflammatory response of sepsis through the p38 MAPK signaling pathway, and it can regulate its own expression through a positive feedback loop, providing a potential therapeutic target for LPS-induced inflammation.

ANNALS OF PALLIATIVE MEDICINE (2021)

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Article Immunology

Clinical Significance of the Serum lncRNA NORAD Expression in Patients with Neonatal Sepsis and Its Association with miR-410-3p

Hong Zhang et al.

Summary: The study validated elevated NORAD levels in NS patients as a potential diagnostic marker and demonstrated that NORAD knockdown reversed the inflammation actions in macrophage cells influenced by LPS. MiR-410-3p was identified as a target of NORAD and found to be downregulated in NS patients.

JOURNAL OF INFLAMMATION RESEARCH (2021)

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Article Biochemistry & Molecular Biology

Circ_0091702 relieves lipopolysaccharide (LPS)-induced cell injury by regulating the miR-182/PDE7A axis in sepsis

Xinliang Zhang et al.

Summary: Circ_0091702 regulates PDE7A by sponging MiR-182, thereby alleviating cell injury induced by LPS in sepsis.

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2021)

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Article Medicine, Research & Experimental

Clinical value and role of microRNA-29c-3p in sepsis-induced inflammation and cardiac dysfunction

Bingyu Zhang et al.

Summary: This study found that miR-29c-3p is upregulated in sepsis patients and can distinguish sepsis patients from healthy controls. In a rat sepsis model, cardiac dysfunction and inflammation were observed, but these effects were reversed by injecting miR-29c-3p antagomir. Logistic regression analysis indicated that miR-29c-3p is an independent factor in the occurrence of cardiac dysfunction in sepsis patients.

EUROPEAN JOURNAL OF MEDICAL RESEARCH (2021)

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Article Medicine, General & Internal

Knockdown of lncRNA TapSAKI alleviates LPS-induced injury in HK-2 cells through the miR-205/IRF3 pathway

Xiaoning Han et al.

Summary: In sepsis, TapSAKI plays a role in regulating cell apoptosis and inflammation by modulating pathways such as miR-205 and the IRF3 signaling pathway, offering a new target for disease treatment.

OPEN MEDICINE (2021)

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Article Medicine, General & Internal

Long Non-Coding RNA RMRP Contributes to Sepsis-Induced Acute Kidney Injury

Xia Zhang et al.

Summary: The study revealed that lncRNA RMRP contributes to sepsis-induced AKI by upregulating DDX5 in a miR-206 dependent manner and by activating NLRP3 inflammasome. This novel discovery may provide a potential strategy for treating AKI.

YONSEI MEDICAL JOURNAL (2021)

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Article Cell Biology

miR-182-5p contributes to intestinal injury in a murine model of Staphylococcus aureus pneumonia-induced sepsis via targeting surfactant protein D

Xianjin Du et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2020)

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Article Cell Biology

Long non-coding RNA MALAT1 sponges miR-149 to promote inflammatory responses of LPS-induced acute lung injury by targeting MyD88

Wei-Jun Liang et al.

CELL BIOLOGY INTERNATIONAL (2020)

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Article Biochemistry & Molecular Biology

Linkage of lncRNA CRNDE sponging miR-181a-5p with aggravated inflammation underlying sepsis

Yijun Wang et al.

INNATE IMMUNITY (2020)

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Article Biochemistry & Molecular Biology

Shikonin improve sepsis-induced lung injury via regulation of miRNA-140-5p/TLR4-a vitro and vivo study

Ying Ying Zhang et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2020)

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Article Immunology

MiR-608 Exerts Anti-inflammatory Effects by Targeting ELANE in Monocytes

Wei Gu et al.

JOURNAL OF CLINICAL IMMUNOLOGY (2020)

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Article Medical Laboratory Technology

The predictive value of microRNA-21 for sepsis risk and its correlation with disease severity, systemic inflammation, and 28-day mortality in sepsis patients

Lei Na et al.

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2020)

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Article Medical Laboratory Technology

MiR-125b but not miR-125a is upregulated and exhibits a trend to correlate with enhanced disease severity, inflammation, and increased mortality in sepsis patients

Xiaoping Zhu

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2020)

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Article Critical Care Medicine

PLASMA MIR-370-3P AS A BIOMARKER OF SEPSIS-ASSOCIATED ENCEPHALOPATHY, THE TRANSCRIPTOMIC PROFILING ANALYSIS OF MICRORNA-ARRAYS FROM MOUSE BRAINS

Peerapat Visitchanakun et al.

SHOCK (2020)

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Article Biochemistry & Molecular Biology

CircPRKCI relieves lipopolysaccharide-induced HK2 cell injury by upregulating the expression of miR-545 target gene ZEB2

Xiaofeng Shi et al.

BIOFACTORS (2020)

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Article Infectious Diseases

Plasma Hsa-miR-92a-3p in correlation with lipocalin-2 is associated with sepsis-induced coagulopathy

Yishan Wang et al.

BMC INFECTIOUS DISEASES (2020)

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Article Biochemistry & Molecular Biology

Up-regulation of microRNA-574 attenuates lipopolysaccharide- or cecal ligation and puncture-induced sepsis associated with acute lung injury

Wenwen Sun et al.

CELL BIOCHEMISTRY AND FUNCTION (2020)

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Article Medicine, Research & Experimental

LncRNA KCNQ1OT1 attenuates sepsis-induced myocardial injury via regulating miR-192-5p/XIAP axis

Fangyuan Sun et al.

EXPERIMENTAL BIOLOGY AND MEDICINE (2020)

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Article Cell Biology

lncRNA RMRP Prevents Mitochondrial Dysfunction and Cardiomyocyte Apoptosis via the miR-1-5p/hsp70 Axis in LPS-Induced Sepsis Mice

Ying Han et al.

INFLAMMATION (2020)

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Article Cell Biology

被撤回的出版物: Silencing of long non-coding RNA MALAT1 suppresses inflammation in septic mice: role of microRNA-23a in the down-regulation of MCEMP1 expression (Retracted article. See OCT, 2022)

Wenfeng Xie et al.

INFLAMMATION RESEARCH (2020)

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Article Immunology

Down-regulation of LncRNA CRNDE aggravates kidney injury via increasing MiR-181a-5p in sepsis

Jiqin Wang et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2020)

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Article Immunology

MiR-215-5p inhibits the inflammation injury in septic H9c2 by regulating ILF3 and LRRFIP1

Yulong Yao et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2020)

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Article Medicine, Research & Experimental

Long non-coding RNA CASC2 ameliorates sepsis-induced acute kidney injury by regulating the miR-155 and NF-κB pathway

Min Wang et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2020)

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Article Biochemistry & Molecular Biology

Reduced miR-26b Expression in Megakaryocytes and Platelets Contributes to Elevated Level of Platelet Activation Status in Sepsis

Bernadett Szilagyi et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Biochemistry & Molecular Biology

Long noncoding RNA colorectal neoplasia differentially expressed alleviates sepsis-induced liver injury via regulating miR-126-5p

Yang Li et al.

IUBMB LIFE (2020)

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Article Biochemistry & Molecular Biology

Long noncoding RNA HOXA-AS2 mediates microRNA-106b-5p to repress sepsis-engendered acute kidney injury

Huifeng Wu et al.

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2020)

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Article Medical Laboratory Technology

Lnc-MEG3 acts as a potential biomarker for predicting increased disease risk, systemic inflammation, disease severity, and poor prognosis of sepsis via interacting with miR-21

Lei Na et al.

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2020)

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Article Medical Laboratory Technology

Correlation of microRNA-125a/b with acute respiratory distress syndrome risk and prognosis in sepsis patients

Shilei Li et al.

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2020)

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Article Medical Laboratory Technology

Plasma miR-125a and miR-125b in sepsis: Correlation with disease risk, inflammation, severity, and prognosis

Danna Zhao et al.

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2020)

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Article Cell Biology

miR-10a in Peripheral Blood Mononuclear Cells Is a Biomarker for Sepsis and Has Anti-Inflammatory Function

Guoping Zheng et al.

MEDIATORS OF INFLAMMATION (2020)

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Article Cell Biology

MEG3 Alleviated LPS-Induced Intestinal Injury in Sepsis by Modulating miR-129-5p and Surfactant Protein D

Xianjin Du et al.

MEDIATORS OF INFLAMMATION (2020)

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Article Cell Biology

Depression of lncRNA NEAT1 Antagonizes LPS-Evoked Acute Injury and Inflammatory Response in Alveolar Epithelial Cells via HMGB1-RAGE Signaling

Hongchao Zhou et al.

MEDIATORS OF INFLAMMATION (2020)

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Article Biochemistry & Molecular Biology

LncRNA NEAT1 reversed the hindering effects of miR-495-3p/STAT3 axis and miR-211/PI3K/AKT axis on sepsis-relevant inflammation

Demeng Xia et al.

MOLECULAR IMMUNOLOGY (2020)

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Article Oncology

Long non-coding RNA MALAT1 serves as an independent predictive biomarker for the diagnosis, severity and prognosis of patients with sepsis

Jianjun Chen et al.

MOLECULAR MEDICINE REPORTS (2020)

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Article Oncology

ATG7 promotes autophagy in sepsis-induced acute kidney injury and is inhibited by miR-526b

Liu Ying et al.

MOLECULAR MEDICINE REPORTS (2020)

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Review Genetics & Heredity

Circular RNA: biogenesis, degradation, functions and potential roles in mediating resistance to anticarcinsuogens

Xiuchao Geng et al.

EPIGENOMICS (2020)

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Article Respiratory System

LncRNA TUG1 alleviates sepsis-induced acute lung injury by targeting miR-34b-5p/GAB1

Nan Qiu et al.

BMC PULMONARY MEDICINE (2020)

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Article Biochemistry & Molecular Biology

LncRNA CYTOR attenuates sepsis-induced myocardial injury via regulating miR-24/XIAP

Ting Chen et al.

CELL BIOCHEMISTRY AND FUNCTION (2020)

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Article Cell Biology

Inhibition of miR-103a-3p suppresses lipopolysaccharide-induced sepsis and liver injury by regulating FBXW7 expression

Yu-Ping Zhou et al.

CELL BIOLOGY INTERNATIONAL (2020)

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Article Medicine, Research & Experimental

Long Noncoding RNA DANCR Suppressed Lipopolysaccharide-Induced Septic Acute Kidney Injury by Regulating miR-214 in HK-2 Cells

Huajie Zhao et al.

MEDICAL SCIENCE MONITOR (2020)

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Article Medicine, Research & Experimental

The Biomarker TCONS_00016233 Drives Septic AKI by Targeting the miR-22-3p/AIFM1 Signaling Axis

Pan Zhang et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2020)

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Article Cell Biology

Downregulation of lncRNA NEAT1 Ameliorates LPS-Induced Inflammatory Responses by Promoting Macrophage M2 Polarization via miR-125a-5p/TRAF6/TAK1 Axis

Wei Wang et al.

INFLAMMATION (2020)

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Article Cell Biology

Down-regulation of lncRNA CASC9 aggravates sepsis-induced acute lung injury by regulating miR-195-5p/PDK4 axis

Huai-rong Wang et al.

INFLAMMATION RESEARCH (2020)

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Article Immunology

被撤回的出版物: MicroRNA-208-5p regulates myocardial injury of sepsis mice via targeting SOCS2-mediated NF-κB/HIF-1α pathway (Retracted article. See vol. 117, 2023)

Haichun Ouyang et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2020)

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Article Cell Biology

Down-regulation of circDMNT3B is conducive to intestinal mucosal permeability dysfunction of rats with sepsis via sponging miR-20b-5p

Liu Jiao et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

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Article Medicine, General & Internal

NEAT1 promotes LPS-induced inflammatory injury in macrophages by regulating miR-17-5p/TLR4

Yanhui Li et al.

OPEN MEDICINE (2020)

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Article Medical Laboratory Technology

Long non-coding RNA MALAT1/microRNA 125a axis presents excellent value in discriminating sepsis patients and exhibits positive association with general disease severity, organ injury, inflammation level, and mortality in sepsis patients

Wei Liu et al.

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2020)

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Article Immunology

miR-145a Regulation of Pericyte Dysfunction in a Murine Model of Sepsis

Yan Wu et al.

JOURNAL OF INFECTIOUS DISEASES (2020)

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Article Oncology

Effects and Mechanism of lncRNA CRNDE on Sepsis-Induced Acute Kidney Injury

Shen Wu et al.

ANALYTICAL CELLULAR PATHOLOGY (2020)

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Article Biology

lncRNA NEAT1 mediates sepsis progression by regulating Irak2 via sponging miR-370-3p

Ting Xiao et al.

BIOLOGY OPEN (2020)

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Article Cell Biology

ADAR1 Alleviates Inflammation in a Murine Sepsis Model via the ADAR1-miR-30a-SOCS3 Axis

Shangxun Zhou et al.

MEDIATORS OF INFLAMMATION (2020)

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Article Cell Biology

miR-199a-5p Exacerbated Intestinal Barrier Dysfunction through Inhibiting Surfactant Protein D and Activating NF-κB Pathway in Sepsis

Xianjin Du et al.

MEDIATORS OF INFLAMMATION (2020)

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Article Medicine, General & Internal

Correlation of microRNA-146a/b with disease risk, biochemical indices, inflammatory cytokines, overall disease severity, and prognosis of sepsis

Li Chen et al.

MEDICINE (2020)

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Article Immunology

Endothelial HSPA12B Exerts Protection Against Sepsis-Induced Severe Cardiomyopathy via Suppression of Adhesion Molecule Expression by miR-126

Xia Zhang et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Medicine, General & Internal

NEAT1 aggravates sepsis-induced acute kidney injury by sponging miR-22-3p

Yawei Feng et al.

OPEN MEDICINE (2020)

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Review Psychiatry

Circular RNA in Schizophrenia and Depression

Zexuan Li et al.

FRONTIERS IN PSYCHIATRY (2020)

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Article Biochemistry & Molecular Biology

LncRNA MIAT Promotes Inflammation and Oxidative Stress in Sepsis-Induced Cardiac Injury by Targeting miR-330-5p/TRAF6/NF-κB Axis

Peng-Cheng Xing et al.

BIOCHEMICAL GENETICS (2020)

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Article Biochemistry & Molecular Biology

MiR-22-3p suppresses sepsis-induced acute kidney injury by targeting PTEN

Xudong Wang et al.

BIOSCIENCE REPORTS (2020)

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Article Biochemistry & Molecular Biology

LPS promotes the progression of sepsis by activation of lncRNA HULC/miR-204-5p/TRPM7 network in HUVECs

Xinghai Chen et al.

BIOSCIENCE REPORTS (2020)

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Article Biochemistry & Molecular Biology

MiR-96-5p alleviates inflammatory responses by targeting NAMPT and regulating the NF-κB pathway in neonatal sepsis

Xueli Chen et al.

BIOSCIENCE REPORTS (2020)

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Article Orthopedics

Long non-coding RNA CCHE1 participates in postoperative distant recurrence but not local recurrence of osteosarcoma possibly by interacting with ROCK1

Zhi Zhang et al.

BMC MUSCULOSKELETAL DISORDERS (2020)

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Article Biology

Low expression of microRNA-328 can predict sepsis and alleviate sepsis-induced cardiac dysfunction and inflammatory response

Bin Sun et al.

BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH (2020)

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Article Cell Biology

miR-128-3p Inhibits NRP1 Expression and Promotes Inflammatory Response to Acute Kidney Injury in Sepsis

Lin Wang et al.

INFLAMMATION (2020)

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Article Physiology

Long Noncoding RNA TCONS_00016406 Attenuates Lipopolysaccharide-Induced Acute Kidney Injury by Regulating the miR-687/PTEN Pathway

Xuelan Liu et al.

FRONTIERS IN PHYSIOLOGY (2020)

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Article Medicine, Research & Experimental

Exosomal Transfer of LCP1 Promotes Osteosarcoma Cell Tumorigenesis and Metastasis by Activating the JAK2/STAT3 Signaling Pathway

Xuhui Ge et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2020)

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Article Immunology

Extracellular Vesicles From Adipose Tissue-Derived Stem Cells Affect Notch-miR148a-3p Axis to Regulate Polarization of Macrophages and Alleviate Sepsis in Mice

Xiaozhi Bai et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Immunology

MicroRNA-34a Inhibition Alleviates Lung Injury in Cecal Ligation and Puncture Induced Septic Mice

Song Chen et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Editorial Material Genetics & Heredity

Long Non-coding RNAs in the Regulation of the Immune Response and Trained Immunity

Manuel Flores-Concha et al.

FRONTIERS IN GENETICS (2020)

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Article Biophysics

Knockdown of LncRNA DLX6-AS1 inhibits HK-2 cell pyroptosis via regulating miR-223-3p/NLRP3 pathway in lipopolysaccharide-induced acute kidney injury

Jixiang Tan et al.

JOURNAL OF BIOENERGETICS AND BIOMEMBRANES (2020)

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Article Medical Laboratory Technology

Long noncoding RNA NEAT 1 and its target microRNA-125a in sepsis: Correlation with acute respiratory distress syndrome risk, biochemical indexes, disease severity, and 28-day mortality

Yongkai Yang et al.

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2020)

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Article Medical Laboratory Technology

The potential of microRNA-126 in predicting disease risk, mortality of sepsis, and its correlation with inflammation and sepsis severity

Run Lin et al.

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2020)

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Article Medicine, Research & Experimental

Diagnostic value of miR-155 for acute lung injury/acute respiratory distress syndrome in patients with sepsis

Zhou-Feng Wang et al.

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH (2020)

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Article Medicine, Research & Experimental

miR-34b-3p protects against acute kidney injury in sepsis mice via targeting ubiquitin-like protein 4A

Shu-Yin He et al.

KAOHSIUNG JOURNAL OF MEDICAL SCIENCES (2020)

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Article Medicine, Research & Experimental

被撤回的出版物: Protective role of long noncoding RNA CRNDE in myocardial tissues from injury caused by sepsis through the microRNA-29a/SIRT1 axis (Retracted article. See vol. 308, 2022)

Yan Zhu et al.

LIFE SCIENCES (2020)

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Article Medicine, Research & Experimental

Berberine attenuates Aβ42-induced neuronal damage through regulating circHDAC9/miR-142-5p axis in human neuronal cells

Nan Zhang et al.

LIFE SCIENCES (2020)

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Article Medicine, General & Internal

Decreased microRNA 103 and microRNA 107 predict increased risks of acute respiratory distress syndrome and 28-day mortality in sepsis patients

Qianqian Wang et al.

MEDICINE (2020)

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Article Multidisciplinary Sciences

Over-expression of miR-223 induces M2 macrophage through glycolysis alteration and attenuates LPS-induced sepsis mouse model, the cell-based therapy in sepsis

Cong Phi Dang et al.

PLOS ONE (2020)

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Article Oncology

Endothelial progenitor cells-secreted extracellular vesicles containing microRNA-93-5p confer protection against sepsis-induced acute kidney injury via the KDM6B/H3K27me3/TNF-α axis

Zhonghua He et al.

EXPERIMENTAL CELL RESEARCH (2020)

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Article Genetics & Heredity

Circular RNA circ_0001105 protects the intestinal barrier of septic rats by inhibiting inflammation and oxidative damage and YAP1 expression

Shaoguang Liu et al.

GENE (2020)

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Article Oncology

MicroRNA-19a Targets Fibroblast Growth Factor-Inducible Molecule 14 and Prevents Tubular Damage in Septic AKI

Jun Hong et al.

ANALYTICAL CELLULAR PATHOLOGY (2020)

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Article Medicine, Research & Experimental

LncRNA NEAT1 promotes apoptosis and inflammation in LPS-induced sepsis models by targeting miR-590-3p

Lingling Liu et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2020)

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Article Cell Biology

Circular RNA VMA21 ameliorates sepsis-associated acute kidney injury by regulating miR-9-3p/SMG1/inflammation axis and oxidative stress

Yan Shi et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

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Article Cell Biology

CircC3P1 attenuated pro-inflammatory cytokine production and cell apoptosis in acute lung injury induced by sepsis through modulating miR-21

Wen-Yang Jiang et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

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Article Medical Laboratory Technology

The value of circulating long non-coding RNA maternally expressed gene 3 as a predictor of higher acute respiratory distress syndrome risk and 28-day mortality in sepsis patients

Xiaoling Wu et al.

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2020)

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Article Immunology

LncRNA THRIL is upregulated in sepsis and sponges miR-19a to upregulate TNF-α in human bronchial epithelial cells

Tao Liu et al.

JOURNAL OF INFLAMMATION-LONDON (2020)

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Article Biochemistry & Molecular Biology

LncRNA THRIL aggravates sepsis-induced acute lung injury by regulating miR-424/ROCK2 axis

Huibin Chen et al.

MOLECULAR IMMUNOLOGY (2020)

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Article Oncology

Potential role of lncRNA HULC/miR-128-3p/RAC1 axis in the inflammatory response during LPS-induced sepsis in HMEC-1 cells

Weize Yang et al.

MOLECULAR MEDICINE REPORTS (2020)

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Article Medicine, Research & Experimental

Circular RNA PRKCI and microRNA-545 relate to sepsis risk, disease severity and 28-day mortality

Bohua Wei et al.

SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION (2020)

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Article Multidisciplinary Sciences

The protective role of miR-223 in sepsis-induced mortality

Dan Liu et al.

SCIENTIFIC REPORTS (2020)

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Article Biotechnology & Applied Microbiology

Nrp-1 Mediated Plasmatic Ago2 Binding miR-21a-3p Internalization: A Novel Mechanism for miR-21a-3p Accumulation in Renal Tubular Epithelial Cells during Sepsis

Zhiqiang Zou et al.

BIOMED RESEARCH INTERNATIONAL (2020)

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Article Biotechnology & Applied Microbiology

Overexpression of miR-150-5p Alleviates Apoptosis in Sepsis-Induced Myocardial Depression

Xiao Geng Zhu et al.

BIOMED RESEARCH INTERNATIONAL (2020)

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Article Health Care Sciences & Services

The correlations between the serum expression of miR-206 and the severity and prognosis of sepsis

Guiwen Liang et al.

ANNALS OF PALLIATIVE MEDICINE (2020)

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Article Pathology

Down-regulation of long noncoding RNA LINC00472 alleviates sepsis-induced acute hepatic injury by regulating miR-373-3p/TRIM8 axis

Lei Li et al.

EXPERIMENTAL AND MOLECULAR PATHOLOGY (2020)

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Article

Study on the Efficacy of Nanoantibiotics in Rats with Sepsis Based on MicroRNA-195 and TGF-β1/Smads Signaling Pathway

Pengcheng Zheng et al.

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY (2020)

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TUG1 Represses Apoptosis, Autophagy, and Inflammatory Response by Regulating miR-27a-3p/SLIT2 in Lipopolysaccharide-Treated Vascular Endothelial Cells

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LncRNA LUADT1 sponges miR-195 to prevent cardiac endothelial cell apoptosis in sepsis

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LncRNA-5657 silencing alleviates sepsis-induced lung injury by suppressing the expression of spinster homology protein 2

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MiRNA-133a aggravates inflammatory responses in sepsis by targeting SIRT1

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Down-regulation of Xist and Mir-7a-5p improves LPS-induced myocardial injury

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lncRNA SNHG1 Knockdown Alleviates Amyloid-β-Induced Neuronal Injury by Regulating ZNF217 via Sponging miR-361-3p in Alzheimer's Disease

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Article Medicine, Research & Experimental

Long Non-Coding RNA Nuclear Paraspeckle Assembly Transcript 1 (NEAT1)Relieves Sepsis-Induced Kidney Injury and Lipopolysaccharide (LPS)-Induced Inflammation in HK-2 Cells

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MiR-145 negatively regulates TGFBR2 signaling responsible for sepsis-induced acute lung injury

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Honokiol alleviates sepsis-induced acute kidney injury in mice by targeting the miR-218-5p/heme oxygenase-1 signaling pathway

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miR-146a targeted to splenic macrophages prevents sepsis-induced multiple organ injury

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MicroRNA-140 inhibits skeletal muscle glycolysis and atrophy in endotoxin-induced sepsis in mice via the WNT signaling pathway

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A TGFBR2/SMAD2/DNMT1/miR-145 negative regulatory loop is responsible for LPS-induced sepsis

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microRNA-30a inhibits the liver cell proliferation and promotes cell apoptosis through the JAK/STAT signaling pathway by targeting SOCS-1 in rats with sepsis

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Elevated circulating lnc-ANRIL/miR-125a axis level predicts higher risk, more severe disease condition, and worse prognosis of sepsis

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BMC PULMONARY MEDICINE (2019)

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MiR-21-3p Plays a Crucial Role in Metabolism Alteration of Renal Tubular Epithelial Cells during Sepsis Associated Acute Kidney Injury via AKT/CDK2-FOXO1 Pathway

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Increased Expression of lncRNA UCA1 and HULC Is Required for Pro-inflammatory Response During LPS Induced Sepsis in Endothelial Cells

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MicroRNA-191-5p diminished sepsis-induced acute kidney injury through targeting oxidative stress responsive 1 in rat models

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microRNA-98 protects sepsis mice from cardiac dysfunction, liver and lung injury by negatively regulating HMGA2 through inhibiting NF-κB signaling pathway

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Potential role of circulating long noncoding RNA MALAT1 in predicting disease risk, severity, and patients' survival in sepsis

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Long non-coding RNA THRIL predicts increased acute respiratory distress syndrome risk and positively correlates with disease severity, inflammation, and mortality in sepsis patients

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MicroRNA-203 Acts as a Potent Suppressor in Septic Shock by Alleviating Lung Injury via Inhibition of VNN1

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miR-21 promotes NLRP3 inflammasome activation to mediate pyroptosis and endotoxic shock

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Long noncoding RNA nuclear enriched abundant transcript 1/miRNA-124 axis correlates with increased disease risk, elevated inflammation, deteriorative disease condition, and predicts decreased survival of sepsis

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Article Medicine, Research & Experimental

Long non-coding RNA-HOTAIR promotes the progression of sepsis by acting as a sponge of miR-211 to induce IL-6R expression

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High lncRNA MEG3 expression is associated with high mortality rates in patients with sepsis and increased lipopolysaccharide-induced renal epithelial cell and cardiomyocyte apoptosis

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LncRNA NEAT1 promotes inflammatory response in sepsis-induced liver injury via the Let-7a/TLR4 axis

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MicroRNA-124 alleviates the lung injury in mice with septic shock through inhibiting the activation of the MAPK signaling pathway by downregulating MAPK14

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Diagnostic and prognostic significance of serum miRNA-146-a expression in Egyptian children with sepsis in a pediatric intensive care unit

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miR-23b Negatively Regulates Sepsis-Induced Inflammatory Responses by Targeting ADAM10 in Human THP-1 Monocytes

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Schisandrin B Attenuates Inflammation in LPS-Induced Sepsis Through miR-17-5p Downregulating TLR4

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LncRNA TapSAKI promotes inflammation injury in HK-2 cells and urine derived sepsis-induced kidney injury

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Delayed Remote Ischemic Preconditioning Confers Renoprotection against Septic Acute Kidney Injury via Exosomal miR-21

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MiR-106a aggravates sepsis-induced acute kidney injury by targeting THBS2 in mice model

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ACTA CIRURGICA BRASILEIRA (2019)

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MicroRNA-495 serves as a diagnostic biomarker in patients with sepsis and regulates sepsis-induced inflammation and cardiac dysfunction

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EUROPEAN JOURNAL OF MEDICAL RESEARCH (2019)

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Circulating lncRNA NEAT1 correlates with increased risk, elevated severity and unfavorable prognosis in sepsis patients

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SIRT1 regulates inflammation response of macrophages in sepsis mediated by long noncoding RNA

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MicroRNA-34a promotes iNOS secretion from pulmonary macrophages in septic suckling rats through activating STAT3 pathway

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MicroRNA-30e promotes hepatocyte proliferation and inhibits apoptosis in cecal ligation and puncture-induced sepsis through the JAK/STAT signaling pathway by binding to FOSL2

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miR-25 inhibits sepsis-induced cardiomyocyte apoptosis by targetting PTEN

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MiR-146b protect against sepsis induced mice myocardial injury through inhibition of Notch1

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MEDICINE (2018)

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microRNA-300/NAMPT regulates inflammatory responses through activation of AMPK/mTOR signaling pathway in neonatal sepsis

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MicroRNA-146a protects against LPS-induced organ damage by inhibiting Notch1 in macrophage

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INTERNATIONAL IMMUNOPHARMACOLOGY (2018)

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被撤回的出版物: MicroRNA-494 inhibition alleviates acute lung injury through Nrf2 signaling pathway via NQO1 in sepsis-associated acute respiratory distress syndrome (Retracted article. See vol. 325, 2023)

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LIFE SCIENCES (2018)

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LncRNA HOX transcript antisense RNA accelerated kidney injury induced by urine-derived sepsis through the miR-22/high mobility group box 1 pathway

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miR-146a Attenuates Sepsis-Induced Myocardial Dysfunction by Suppressing IRAK1 and TRAF6 via Targeting ErbB4 Expression

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Propofol attenuates sepsis-induced acute kidney injury by regulating miR-290-5p/CCL-2 signaling pathway

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GSKJ4 Protects Mice Against Early Sepsis via Reducing Proinflammatory Factors and Up-Regulating MiR-146a

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Stat3 and C/EBPβ synergize to induce miR-21 and miR-181b expression during sepsis

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MicroRNA-135a is up-regulated and aggravates myocardial depression in sepsis via regulating p38 MAPK/NF-κB pathway

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Anti-inflammatory effects of curcumin are associated with down regulating microRNA-155 in LPS-treated macrophages and mice

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MiRNA-21 has effects to protect kidney injury induced by sepsis

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A model-specific role of microRNA-223 as a mediator of kidney injury during experimental sepsis

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Cytoprotective Effect of Heat Shock Protein 27 Against Lipopolysaccharide-Induced Apoptosis of Renal Epithelial HK-2 Cells

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MicroRNA-21 Is Required for Local and Remote Ischemic Preconditioning in Multiple Organ Protection Against Sepsis

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miR-375 ameliorates sepsis by downregulating miR-21 level via inhibiting JAK2-STAT3 signaling

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Diagnostic Value of the lncRNA NEAT1 in Peripheral Blood Mononuclear Cells of Patients with Sepsis

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DISEASE MARKERS (2017)

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Inhibition of MicroRNA 195 Prevents Apoptosis and Multiple-Organ Injury in Mouse Models of Sepsis

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MicroRNA-150 Suppression of Angiopoetin-2 Generation and Signaling Is Crucial for Resolving Vascular Injury

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LncRNA-HOTAIR promotes TNF-α production in cardiomyocytes of LPS-induced sepsis mice by activating NF-κB pathway

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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2016)

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The Prognostic Value of Plasma MicroRNA-155 and MicroRNA-146a Level in Severe Sepsis and Sepsis-Induced Acute Lung Injury Patients

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MicroRNA-205-5b inhibits HMGB1 expression in LPS-induced sepsis

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INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2016)

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MicroRNA-125b Prevents Cardiac Dysfunction in Polymicrobial Sepsis by Targeting TRAF6-Mediated Nuclear Factor κB Activation and p53-Mediated Apoptotic Signaling

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Diagnostic value of elevated serum miRNA-143 levels in sepsis

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miR-21-3p controls sepsis-associated cardiac dysfunction via regulating SORBS2

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JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2016)

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Spherical nucleic acid targeting microRNA-99b enhances intestinal MFG-E8 gene expression and restores enterocyte migration in lipopolysaccharide-induced septic mice

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rhTNFR:Fc increases Nrf2 expression via miR-27a mediation to protect myocardium against sepsis injury

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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)

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Pathogenesis of Multiple Organ Failure in Sepsis

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CRITICAL REVIEWS IN IMMUNOLOGY (2015)

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Circulating MicroRNA-223 Serum Levels Do Not Predict Sepsis or Survival in Patients with Critical Illness

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DISEASE MARKERS (2015)

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EMBO MOLECULAR MEDICINE (2015)

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Elevated miR-155 expression induces immunosuppression via CD39+ regulatory T-cells in sepsis patient

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INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2015)

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Attenuation of Cardiac Dysfunction in Polymicrobial Sepsis by MicroRNA-146a Is Mediated via Targeting of IRAK1 and TRAF6 Expression

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Inhibition of microRNA-155 relieves sepsis-induced liver injury through inactivating the JAK/STAT pathway

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MOLECULAR MEDICINE REPORTS (2015)

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Exosomal miR-223 Contributes to Mesenchymal Stem Cell-Elicited Cardioprotection in Polymicrobial Sepsis

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MicroRNA-19a and CD22 Comprise a Feedback Loop for B Cell Response in Sepsis

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MEDICAL SCIENCE MONITOR (2015)

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MicroRNA-146a controls Th1-cell differentiation of human CD4+ T lymphocytes by targeting PRKCε

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EUROPEAN JOURNAL OF IMMUNOLOGY (2015)

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miR-27a is up regulated and promotes inflammatory response in sepsis

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CELLULAR IMMUNOLOGY (2014)

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Serum miR-122 levels are related to coagulation disorders in sepsis patients

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Levels of Circulating miR-133a Are Elevated in Sepsis and Predict Mortality in Critically Ill Patients

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MicroRNA 21 (miR-21) and miR-181b Couple with NFI-A To Generate Myeloid-Derived Suppressor Cells and Promote Immunosuppression in Late Sepsis

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