4.8 Article

Tocilizumab (TCZ) Decreases Angiogenesis in Rheumatoid Arthritis Through Its Regulatory Effect on miR-146a-5p and EMMPRIN/CD147

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Decreased serum levels of the inflammaging marker miR-146a are associated with clinical non-response to tocilizumab in COVID-19 patients

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Summary: The expression levels of miR-146a-5p related to inflammaging changed in COVID-19 patients after receiving treatment with Tocilizumab, with patients who did not respond to the drug having lower levels of miR-146a-5p and experiencing worse outcomes. This blood-based biomarker may offer insights into the molecular link between inflammaging and the clinical course of COVID-19, providing a better understanding for using biologic drugs against this global health threat.

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