Microfluidic chip connected to porous microneedle array for continuous ISF sampling

Minimally invasive biosensing using microneedles (MNs) is a desirable technology for continuous healthcare monitoring. Among a wide range of MNs, porous MNs are expected to be applied for sampling of interstitial fluids (ISF) by connecting the internal tissue to external measurement devices. In order to realize a continuous measurement of biomarkers in ISF through porous MNs, their integration with a microfluidic chip is a promising approach due to its applicability to micro-total analysis system (mu TAS) technology. In this study, we developed a fluidic system to directly interface porous MNs to a microfluidic chip consisting of a capillary pump for the continuous sampling of ISF. The porous and flexible MNs made of PDMS are connected to the microfluidic chip fabricated by standard microelectro-mechanical system (MEMS) processes, showing a continuous flow of phosphate buffered saline (PBS). The developed device will lead to the minimally invasive and continuous biosampling for long-term healthcare monitoring.

Automated summary

The study developed a fluidic system that directly interfaces porous microneedles with a microfluidic chip for continuous sampling of ISF. Porous and flexible microneedles made of PDMS are connected to the microfluidic chip, showing continuous flow of phosphate buffered saline (PBS). This integrated device offers minimally invasive and continuous biosampling for long-term healthcare monitoring.