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Cell-Free Biomimetic Mineralization Strategies to Regenerate the Enamel Microstructure

期刊

CRYSTALS
卷 11, 期 11, 页码 -

出版社

MDPI
DOI: 10.3390/cryst11111385

关键词

enamel-inspired mineralization; enamel-like structure; biomineralization; biomimetic mineralization

资金

  1. NSFC/RGC Joint Research Scheme - Research Grants Council of the Hong Kong Special Administrative Region, China
  2. National Natural Science Foundation of China [N-HKU706/20]

向作者/读者索取更多资源

The unique structure of native enamel gives it exquisite appearance and toughening properties, but damage to enamel is irreversible. Current clinical treatment for enamel lesions is invasive and has limitations, while biomimetic mineralization techniques offer promise for non-invasive enamel restoration.
The distinct architecture of native enamel gives it its exquisite appearance and excellent intrinsic-extrinsic fracture toughening properties. However, damage to the enamel is irreversible. At present, the clinical treatment for enamel lesion is an invasive method; besides, its limitations, caused by the chemical and physical difference between restorative materials and dental hard tissue, makes the restorative effects far from ideal. With more investigations on the mechanism of amelogenesis, biomimetic mineralization techniques for enamel regeneration have been well developed, which hold great promise as a non-invasive strategy for enamel restoration. This review disclosed the chemical and physical mechanism of amelogenesis; meanwhile, it overviewed and summarized studies involving the regeneration of enamel microstructure in cell-free biomineralization approaches, which could bring new prospects for resolving the challenges in enamel regeneration.

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