期刊
BIOENGINEERED
卷 12, 期 2, 页码 9860-9871出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/21655979.2021.1996149
关键词
Acute toxicity; analgesia; eye irritation; pain-related factor; skin irritation
资金
- Key R&D Program of Jiangsu Province [BE2019362]
Research showed that Borneol essential oil has good analgesic effects, significantly reducing writhing pain in mice, and also explored the mechanism of its analgesic effects.
Cinnamomum camphora chvar. Borneol essential oil (BEO, 18.2% v/v borneol) is a by-product of steam distillation to produce natural crystalline borneol (NCB, 98.4% v/v borneol). Given the known medicinal properties of borneol, the analgesic function and safety were studied. Horn's method and the Draize test revealed a gender difference in mice regarding acute oral LD50, i.e., low-toxicity to female mice (2749 mg/kg), but practically nontoxic to male mice (5081 mg/kg). There was no acute and skin or eye irritation when BEO was applied directly, if the BEO concentration was less than 50%. The analgesic effect of BEO was evaluated by the glacial acetic acid-induced writhing pain model. Continuous topical application of BEO to the abdomen of mice for 6 d, significantly reduced observed writhing in mice (p < 0.001) with a strong dose-response relationship (r = -0.9006). Concomitantly, the levels of the serum pain-related mediators, prostaglandin E-2 (PGE(2)) and transient receptor potential melastatin-8 (TRPM8) were significantly reduced (p < 0.001), and the latter showed a strong dose-response relationship (r = -0.9427). Therefore, BEO had similar analgesic functions to borneol and was demonstrated to be safe for medicinal use. [GRAPHICS] .
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