4.7 Article

MicroRNA-98-5p modulates cervical cancer progression via controlling PI3K/AKT pathway

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

LncRNA NEAT1 promotes glioma cancer progression via regulation of miR-98-5p/BZW1

Yabin Li et al.

Summary: NEAT1 plays an oncogenic role in glioma progression by promoting cell proliferation and interacting with miR-98-5p and BZW1. Inhibition of NEAT1 through the miR-98-5p/BZW1 pathway suppresses glioma cell proliferation in vivo. Targeting NEAT1/miR-98-5p/BZW1 may provide a novel therapeutic approach for glioma patients.

BIOSCIENCE REPORTS (2021)

Article Ophthalmology

Circ_0000527 Promotes Retinoblastoma Progression through Modulating miR-98-5p/XIAP Pathway

Binke Yu et al.

Summary: The study revealed that circ_0000527 promotes the progression of RB by regulating the miR-98-5p/XIAP axis, providing a promising therapeutic target for RB.

CURRENT EYE RESEARCH (2021)

Article Oncology

miR-519d-3p/HIF-2α axis increases the chemosensitivity of human cervical cancer cells to cisplatin via inactivation of PI3K/AKT signaling

Lixia Jiang et al.

Summary: The study demonstrated that miR-519d-3p increased DDP resistance in cervical cancer cells by inhibiting HIF-2 alpha protein expression and the PI3K/AKT signaling pathway under hypoxic conditions. However, HIF-2 alpha overexpression reduced the effect of miR-519d-3p overexpression on the cells, ultimately leading to increased DDP resistance.

MOLECULAR MEDICINE REPORTS (2021)

Article Oncology

Exosomal miR-663b exposed to TGF-β1 promotes cervical cancer metastasis and epithelial-mesenchymal transition by targeting MGAT3

Xuewu You et al.

Summary: This study revealed that TGF-beta 1 stimulates cervical cancer cells to release exosomes containing miR-663b, which promotes metastasis. MiR-663b directly targets MGAT3 and is involved in the EMT process that affects cancer cell migration and invasion.

ONCOLOGY REPORTS (2021)

Article Cell Biology

The novel circular RNA circ-PGAP3 retards cervical cancer growth by regulating the miR-769-5p/p53 axis

Jun Tian et al.

Summary: The circular RNA circ-PGAP3 plays a tumor-inhibiting role in cervical cancer by regulating the miR-769-5p/p53 axis, presenting a promising therapeutic target for this disease.

HUMAN CELL (2021)

Article Medicine, Research & Experimental

miR-98-5p inhibits gastric cancer cell stemness and chemoresistance by targeting branched-chain aminotransferases 1

Panpan Zhan et al.

Summary: This study demonstrates that miR-98 inhibits gastric cancer cell stemness and chemoresistance by targeting BCAT1, indicating that the miR-98/BCAT1 axis may serve as a potential therapeutic target in gastric cancer.

LIFE SCIENCES (2021)

Article Medicine, Research & Experimental

LncRNA SNHG11 aggravates cell proliferation and migration in triple-negative breast cancer via sponging miR-2355-5p and targeting CBX5

Lei Yu et al.

Summary: In TNBC, highly expressed SNHG11 promoted cell proliferation and migration, while reducing cell apoptosis. Moreover, SNHG11 interacted with miR-2355-5p and regulated the expression of CBX5. Inhibition of CBX5 suppressed cell proliferation and migration, and overexpression of CBX5 counteracted the inhibitory effect of SNHG11 on TNBC cell growth.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2021)

Article Oncology

Overexpression of Circular RNA circ_0013587 Reverses Erlotinib Resistance in Pancreatic Cancer Cells Through Regulating the miR-1227/E-Cadherin Pathway

Huiting Xu et al.

Summary: The study demonstrated that the down-regulation of circ_0013587 contributes to acquired resistance to erlotinib in pancreatic cancer cells by mediating the miR-1227/E-cadherin pathway, suggesting circ_0013587 as a potential target to overcome erlotinib resistance.

FRONTIERS IN ONCOLOGY (2021)

Article Biotechnology & Applied Microbiology

Long non-coding RNA PTAR inhibits apoptosis but promotes proliferation, invasion and migration of cervical cancer cells by binding miR-101

Xuehe Wang et al.

Summary: The study demonstrated that an aberrant upregulation of PTAR in cervical cancer tissues and cell lines promotes proliferation, migration, and invasion of HeLa cells, while inhibiting apoptosis and downregulating miR-101 expression through direct binding. These findings suggest that PTAR plays a crucial role and may serve as a promising target for cervical cancer diagnosis and therapy.

BIOENGINEERED (2021)

Article Biotechnology & Applied Microbiology

Circular RNA circ_0000228 promotes the malignancy of cervical cancer via microRNA-195-5p/lysyl oxidase-like protein 2 axis

Shimei Liu et al.

Summary: Circular RNAs play a crucial role in cervical cancer by promoting cancer progression through sponging miR-195-5p and up-regulating LOXL2 expression.

BIOENGINEERED (2021)

Article Biotechnology & Applied Microbiology

Long noncoding RNA MST1P2 promotes cervical cancer progression by sponging with microRNA miR-133b

Rongrong Xu et al.

Summary: The study revealed that lncRNA MST1P2 is significantly overexpressed in cervical cancer tissues and cells, with Si-Lnc MST1P2 inhibiting cell growth, migration, and invasion both in vivo and in vitro. Up-regulation of miR-133b inhibited cell viability and metastasis, while its inhibition decreased the anticancer effect of si-Lnc MST1P2. Overall, lncRNA MST1P2 acts as an oncogene in cervical cancer by interacting with miR-133b.

BIOENGINEERED (2021)

Article Biochemistry & Molecular Biology

Circular RNA circBCBM1 promotes breast cancer brain metastasis by modulating miR-125a/BRD4 axis

Bo Fu et al.

Summary: CircBCBM1 is involved in breast cancer brain metastasis through the circBCBM1/miR-125a/BRD4 axis, and it may serve as a novel diagnostic and prognostic biomarker and potential therapeutic target for breast cancer brain metastasis.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

Article Medicine, Research & Experimental

miRNA-98-5p Targeting IGF2BP1 Induces Mesenchymal Stem Cell Apoptosis by Modulating PI3K/Akt and p53 in Immune Thrombocytopenia

Yanan Wang et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2020)

Review Medicine, General & Internal

Cervical Cancer Screening: What's New? Updates for the Busy Clinician

Salina Zhang et al.

AMERICAN JOURNAL OF MEDICINE (2018)

Article Allergy

MicroRNA

Thomas X. Lu et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2018)

Review Biochemistry & Molecular Biology

PTEN/PTENP1: 'Regulating the regulator of RTK-dependent PI3K/Akt signalling', new targets for cancer therapy

Nahal Haddadi et al.

MOLECULAR CANCER (2018)

Article Medicine, Research & Experimental

Cervical cancer screening behavior and associated factors among women of Ugrachandi Nala, Kavre, Nepal

Radha Acharya Pandey et al.

EUROPEAN JOURNAL OF MEDICAL RESEARCH (2017)

Editorial Material Biochemistry & Molecular Biology

miRNA and Cancer; Computational and Experimental Approaches

Yusuf Tutar

CURRENT PHARMACEUTICAL BIOTECHNOLOGY (2014)

Review Pathology

MicroRNAs in Cancer

Yong Sun Lee et al.

ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE (2009)