LncRNA LINC00525 activates HIF-1α through miR-338-3p / UBE2Q1 / β-catenin axis to regulate the Warburg effect in colorectal cancer

Warburg effect is considered to be related to the malignancy of tumor cells under hypoxic conditions, but the underlying mechanism remains unknown. In this article, it has been reported that lncRNA LINC00525 is a hypoxia-responsive lncRNA and is essential for hypoxia-enhanced glycolysis. It was found that LINC00525 was up-regulated, and promoted cell proliferation in colorectal cancer in vitro and in vivo. In colorectal cancer cells, hypoxia increasedLINC00525 expression, whereas knocking down LINC00525 reduced hypoxia-enhanced glycolysis. For specific molecular mechanisms, it was found that LINC00525 promoted UBE2Q1 expression by binding miR-338-3p, and UBE2Q1-stabilized beta-catenin enhances hypoxia-enhanced glycolysis by activating HIF-1 alpha. In conclusion, these findings showed that LINC00525 was essential for hypoxia-enhanced glycolysis; its mechanism was related to activating HIF-1 alpha through miR-338-3p/UBE2Q1/beta-catenin axis in colorectal cancer cells.

Automated summary

This article reports that LINC00525, a hypoxia-responsive lncRNA, is essential for hypoxia-enhanced glycolysis in colorectal cancer cells. It was found that LINC00525 promotes UBE2Q1 expression by binding miR-338-3p, leading to the activation of HIF-1α and enhanced glycolysis under hypoxic conditions.