4.7 Article

Analgesia effect of lentivirus-siSCN9A infected neurons in vincristine induced neuropathic pain rats

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Critical Care Medicine

L5 Spinal Nerve Axotomy Induces Distinct Electrophysiological Changes in Axotomized L5-and Adjacent L4-Dorsal Root Ganglion Neurons in Rats In Vivo

Laiche Djouhri et al.

Summary: Peripheral neuropathic pain (PNP) is a major health issue with limited drug treatment options. Studies suggest that axotomized and uninjured neurons in animal models of PNP show distinct electrophysiological changes. Uninjured neurons exhibit faster action potential kinetics, potentially contributing to the development of PNP.

JOURNAL OF NEUROTRAUMA (2021)

Article Rheumatology

Dorsal root ganglia: fibromyalgia pain factory?

Manuel Martinez-Lavin

Summary: This article discusses the potential role of dorsal root ganglia (DRG) as the main source of pain in fibromyalgia, highlighting their unique anatomical and physiological features and the inflammatory/pro-nociceptive molecules they possess. Experimental data and clinical evidence support the important role of DRG in fibromyalgia and similar syndromes, suggesting them as potential therapeutic targets.

CLINICAL RHEUMATOLOGY (2021)

Article Anesthesiology

Activation of the regeneration-associated gene STAT3 and functional changes in intact nociceptors after peripheral nerve damage in mice

Laura Bernal et al.

Summary: This study found that neuronal regeneration after nerve injury may explain abnormal functional properties gained by intact neurons, reinforcing their role in neuropathic pain. Peripheral nerve damage triggers regenerating programs in axotomized and non-axotomized nociceptors, leading to abnormal spontaneous and evoked discharges.

EUROPEAN JOURNAL OF PAIN (2021)

Review Neurosciences

Pain behavior in SCN9A (Nav1.7) and SCN10A (Nav1.8) mutant rodent models

Yaping Xue et al.

Summary: The review summarizes the findings from rodent models with Scn9a and Scn10a gene mutations, showing that loss-of-function or knockout of these genes decrease pain sensitivity, while certain mutations can lead to painful small fiber neuropathy. Future research on these mutations in preclinical models can provide insights into the impact of these mutations on pain.

NEUROSCIENCE LETTERS (2021)

Article Biochemistry & Molecular Biology

Suppression of TRPV1/TRPM8/P2Y Nociceptors by Withametelin via Downregulating MAPK Signaling in Mouse Model of Vincristine-Induced Neuropathic Pain

Adnan Khan et al.

Summary: This study demonstrated that WMT has a significant neuroprotective effect on VCR-induced neuropathic pain by reducing pain hypersensitivity, inhibiting histopathological changes, regulating biochemical composition, downregulating signaling pathways, and suppressing apoptosis and inflammation.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Biochemistry & Molecular Biology

Insufficient efferocytosis by M2-like macrophages as a possible mechanism of neuropathic pain induced by nerve injury

Daichi Kobayashi et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

Article Medicine, Research & Experimental

Upregulation of Nav1.7 by endogenous hydrogen sulfide contributes to maintenance of neuropathic pain

Jun-Jie Tian et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2020)

Review Physiology

Painful and painless mutations ofSCN9AandSCN11Avoltage-gated sodium channels

Mark D. Baker et al.

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2020)

Article Medicine, Research & Experimental

Voltage-gated sodium channel 1.7 expression decreases in dorsal root ganglia in a spinal nerve ligation neuropathic pain model

Ming Li et al.

KAOHSIUNG JOURNAL OF MEDICAL SCIENCES (2019)

Article Biochemistry & Molecular Biology

N-methyl-d-aspartate Receptors in the Prelimbic Cortex are Critical for the Maintenance of Neuropathic Pain

Priscila Medeiros et al.

NEUROCHEMICAL RESEARCH (2019)

Article Neurosciences

PiRNA-DQ541777 Contributes to Neuropathic Pain via Targeting Cdk5rap1

Chenjing Zhang et al.

JOURNAL OF NEUROSCIENCE (2019)

Review Neurosciences

Microglia in neuropathic pain: cellular and molecular mechanisms and therapeutic potential

Kazuhide Inoue et al.

NATURE REVIEWS NEUROSCIENCE (2018)

Article Cell Biology

Analgesic effect of AG490, a Janus kinase inhibitor, on oxaliplatin-induced acute neuropathic pain

Shuang-Feng Li et al.

NEURAL REGENERATION RESEARCH (2018)

Review Neurosciences

Neuropathic pain following traumatic spinal cord injury: Models, measurement, and mechanisms

John L. K. Kramer et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2017)

Review Biochemistry & Molecular Biology

Analgesic Mechanisms of Antidepressants for Neuropathic Pain

Hideaki Obata

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Review Biochemistry & Molecular Biology

Neuronal and microglial mechanisms for neuropathic pain in the spinal dorsal horn and anterior cingulate cortex

Makoto Tsuda et al.

JOURNAL OF NEUROCHEMISTRY (2017)

Review Multidisciplinary Sciences

Purinergic signaling in microglia in the pathogenesis of neuropathic pain

Kazuhide Inoue

PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES (2017)

Article Medicine, General & Internal

Neuropathic pain

Luana Colloca et al.

NATURE REVIEWS DISEASE PRIMERS (2017)

Article Biochemistry & Molecular Biology

KLF15 regulates dopamine D2 receptor and participates in mouse models of neuropathic pain

Junfei Zhou et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

Review Clinical Neurology

Neuropathic Pain: Central vs. Peripheral Mechanisms

Kathleen Meacham et al.

CURRENT PAIN AND HEADACHE REPORTS (2017)