4.7 Article

The effect and mechanism of cypermethrin-induced hippocampal neurotoxicity as determined by network pharmacology analysis and experimental validation

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Effect of long-term treatment with a mixture of pyrethroids on the expression of genes that govern male germ cell production in rats

Anandha R. Ravula et al.

Summary: The study reveals that long-term exposure to a mixture of pyrethroids can lead to abnormalities in the transcriptome of factors involved in sperm production and development in rats.

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2021)

Article Neurosciences

Cypermethrin Impairs Hippocampal Neurogenesis and Cognitive Functions by Altering Neural Fate Decisions in the Rat Brain

Anuradha Yadav et al.

Summary: Exposure to cypermethrin reduces neural stem cell proliferation, decreases the generation of mature neurons, and increases the number of glial cells and apoptotic cells in the hippocampus, leading to neurogenic imbalance and neurodegeneration, ultimately causing cognitive dysfunction in rats.

MOLECULAR NEUROBIOLOGY (2021)

Article Pharmacology & Pharmacy

Integrating Network Pharmacology and Experimental Validation to Investigate the Effects and Mechanism of Astragalus Flavonoids Against Hepatic Fibrosis

Lin An et al.

Summary: Astragalus membranaceus (AR) is a famous herb in traditional Chinese medicine, and its flavonoid components have been proven to have inhibitory effects on hepatic fibrosis. Through network pharmacology analysis, it was discovered that the flavonoids from AR modulate multiple targets and pathways to exert their pharmacological effects against liver fibrosis. Experimental validation data showed that the flavonoids can suppress activation of hepatic stellate cells and reduce extracellular matrix deposition by regulating the NF-kappa B signal transduction pathway.

FRONTIERS IN PHARMACOLOGY (2021)

Article Chemistry, Medicinal

Study on Hepatotoxicity of Rhubarb Based on Metabolomics and Network Pharmacology

Shanze Li et al.

Summary: The study identified chemical components in rhubarb and their potential targets related to hepatotoxicity, indicating that rhubarb may cause liver toxicity through multiple signaling pathways impacting various receptors and enzymes. The integration of metabolomics technology and network pharmacology provides insights into the mechanism of rhubarb-induced hepatotoxicity for better clinical application.

DRUG DESIGN DEVELOPMENT AND THERAPY (2021)

Article Food Science & Technology

Three widely used pesticides and their mixtures induced cytotoxicity and apoptosis through the ROS-related caspase pathway in HepG2 cells

Tiancai Wang et al.

Summary: The study found that Difenoconazole, cypermethrin, and triazophos exhibit cytotoxicity and induce apoptosis in human hepatocellular carcinoma cells. Mixtures of these pesticides showed stronger toxic effects on cells compared to individual pesticides.

FOOD AND CHEMICAL TOXICOLOGY (2021)

Article Reproductive Biology

Melatonin ameliorates cypermethrin-induced impairments by regulating oxidative stress, DNA damage and apoptosis in porcine Sertoli cells

Jing Li et al.

Summary: The study revealed that cypermethrin (CYP) induced cytotoxicity in porcine Sertoli cells (SCs) through oxidative stress, DNA damage, and apoptosis, and melatonin showed a protective effect against CYP-induced toxicity.

THERIOGENOLOGY (2021)

Article Biochemistry & Molecular Biology

Cypermethrin-induced cortical neurons apoptosis via the Nrf2/ARE signaling pathway

Lihua Zhou et al.

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY (2020)

Review Environmental Sciences

Environmental neurotoxic pollutants: review

Ashif Iqubal et al.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2020)

Article Multidisciplinary Sciences

Methyl-CpG-binding protein 2 mediates overlapping mechanisms across brain disorders

Snow Bach et al.

SCIENTIFIC REPORTS (2020)

Article Medicine, General & Internal

HBx mediated Increase of SIRT1 Contributes to HBV-related Hepatocellular Carcinoma Tumorigenesis

Qing Wang et al.

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES (2020)

Article Biochemistry & Molecular Biology

Dopaminergic Dysfunction in Mammalian Dopamine Neurons Induced by Simazine Neurotoxicity

Xueting Li et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Article Environmental Sciences

Cytotoxicity induced by cypermethrin in Human Neuroblastoma Cell Line SH-SY5Y

Grzegorz Raszewski et al.

ANNALS OF AGRICULTURAL AND ENVIRONMENTAL MEDICINE (2016)

Review Biochemistry & Molecular Biology

Network pharmacology applications to map the unexplored target space and therapeutic potential of natural products

Milla Kibble et al.

NATURAL PRODUCT REPORTS (2015)

Review Neurosciences

Environmental pollutants as risk factors for neurodegenerative disorders: Alzheimer and Parkinson diseases

Miguel Chin-Chan et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2015)

Article Mathematical & Computational Biology

cytoHubba: identifying hub objects and sub-networks from complex interactome

Chia-Hao Chin et al.

BMC SYSTEMS BIOLOGY (2014)