Cancer-associated fibroblast exosomes promote chemoresistance to cisplatin in hepatocellular carcinoma through circZFR targeting signal transducers and activators of transcription (STAT3)/nuclear factor -kappa B (NF-κB) pathway

Article Biotechnology & Applied Microbiology

Has_circ_0008583 modulates hepatocellular carcinoma progression through the miR-1301-3p/METTL3 pathway

Fenfen Wang et al.

Summary: The study found that hsa_circ_0008583 promotes the progression of hepatocellular carcinoma through the miR-1301-3p/METTL3 axis, specifically by promoting cell proliferation, migration, and invasion.

BIOENGINEERED (2022)

添加到收藏夹

Article Oncology

How far have we explored fungi to fight cancer?

Chee Wun How et al.

Summary: The use of fungal-derived materials in cancer research has shown great potential. Capsular polysaccharides, proteins, and other structures derived from fungi have been explored for various innovative applications in the pharmaceutical field. Additionally, bioactive compounds isolated from fungi have been formulated into nanoparticles to enhance their anticancer activity. The progress of fungal compounds in clinical trials and the potential of fungal species for anticancer immunotherapy are also discussed.

SEMINARS IN CANCER BIOLOGY (2022)

添加到收藏夹

Review Medicine, Research & Experimental

Biogenesis, functions, and clinical implications of circular RNAs in non-small cell lung cancer

Ying Liu et al.

Summary: Lung cancer is the leading cause of cancer-related deaths worldwide, and non-small cell lung cancer (NSCLC) is the most common type. Circular RNAs (circRNAs) are a class of non-coding RNAs with specific structures and expression patterns, playing important roles in regulating various processes in NSCLC. CircRNAs have great potential as biomarkers in the diagnosis, prognosis, and treatment of NSCLC.

MOLECULAR THERAPY-NUCLEIC ACIDS (2022)

添加到收藏夹

Article Oncology

Cancer-associated fibroblasts promote hepatocellular carcinoma progression through downregulation of exosomal miR-150-3p

Kyohei Yugawa et al.

Summary: The study revealed that the loss of miR-150-3p in CAFs-derived exosomes significantly promotes HCC progression. Exosomal miR-150-3p may serve as a potential prognostic biomarker, and transferring miR-150-3p-loaded exosomes to HCC cells could be a novel therapeutic option.

EJSO (2021)

添加到收藏夹

Article Oncology

A Positive Feedback Loop of AKR1C3-Mediated Activation of NF-κB and STAT3 Facilitates Proliferation and Metastasis in Hepatocellular Carcinoma

Qingqing Zhou et al.

Summary: AKR1C3 is significantly upregulated in hepatocellular carcinoma (HCC) and associated with poor survival. Through the NF-kappa B/STAT3 signaling loop, AKR1C3 promotes cell proliferation and metastasis, suggesting it could be a promising therapeutic target in HCC.

CANCER RESEARCH (2021)

添加到收藏夹

Article Genetics & Heredity

scLM: Automatic Detection of Consensus Gene Clusters Across Multiple Single-cell Datasets

Qianqian Song et al.

Summary: In gene expression profiling studies, specifically in single-cell RNA sequencing analyses, accurately identifying and clustering co-expressed genes is essential for understanding cell identity and function. Existing methods for single-cell data often fail to accurately identify co-expressed genes, but the scLM algorithm tailored for single-cell data proves to be effective in detecting biologically significant gene clusters and can cluster multiple single-cell datasets simultaneously. Results from simulation and experimental data show that scLM outperforms existing methods and provides novel biological insights for mechanism discovery and understanding complex biosystems like cancer.

GENOMICS PROTEOMICS & BIOINFORMATICS (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Cancer associated-fibroblast-derived exosomes in cancer progression

Chao Li et al.

Summary: Research focuses on various cell types in the tumor microenvironment (TME), particularly on understanding the role of cancer-associated fibroblasts (CAFs) in influencing the communication between cancer cells and other TME cells through the secretion of extracellular vesicles (exosomes). Studies have shown that CAFs play a significant role in tumor progression by remodeling the extracellular matrix, secreting factors, and exosomes.

MOLECULAR CANCER (2021)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Circular RNA UBR1 promotes the proliferation, migration, and invasion but represses apoptosis of lung cancer cells via modulating microRNA-545-5p/SSFA2 axis

Peng Su et al.

Summary: Circular RNA circ-UBR1 is upregulated in lung cancer cells and directly binds to miR-545-5p, repressing its expression. This interaction promotes cell proliferation, migration, and invasion in lung cancer, while inhibiting apoptosis. In vivo experiments also show that knockdown of circ-UBR1 can alleviate the progression of lung cancer by modulating the expression of miR-545-5p and a downstream target gene SSFA2.

BIOENGINEERED (2021)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Exosomes derived from microRNA-129-5p-modified tumor cells selectively enhanced suppressive effect in malignant behaviors of homologous colon cancer cells

Yong Ji et al.

Summary: Exosome-encapsulated microRNAs are promising diagnostic and therapeutic markers for colon cancer. MiRNA-129-5p exosomes have a strong inhibitory effect on colon cancer cell proliferation, migration, and invasion.

BIOENGINEERED (2021)

添加到收藏夹

Article Oncology

Tumor-associated macrophages induced spheroid formation by CCL18-ZEB1-M-CSF feedback loop to promote transcoelomic metastasis of ovarian cancer

Lingli Long et al.

Summary: This study revealed a positive relationship between the formation of OvCa-TAMs spheroids and the malignancy of OvCa cells, with M2-TAMs inducing the epithelial-mesenchymal transition of OvCa cells through the release of CCL18. The overexpression of ZEB1 in OvCa cells in ovarian mice models promoted the formation of OvCa-TAMs spheroids in ascites, leading to faster transcoelomic metastasis.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

添加到收藏夹

Review Medicine, General & Internal

Role of circular RNAs in gastrointestinal tumors and drug resistance

Shi-Jun Xi et al.

Summary: The incidence of gastrointestinal cancers has risen significantly in the past decade, becoming a leading global cause of mortality. Research shows that circRNAs play a crucial role in the occurrence and development of gastrointestinal tumors, potentially affecting drug resistance in these cancers.

WORLD JOURNAL OF CLINICAL CASES (2021)

添加到收藏夹

Article Oncology

Exosomal circEIF3K from cancer-associated fibroblast promotes colorectal cancer (CRC) progression via miR-214/PD-L1 axis

Kaihua Yang et al.

Summary: In this study, a novel axis circEIF3K/miR-214/PD-L1 was revealed to mediate hypoxia-induced CRC progression via CAF, providing a rationale for developing new targeted therapeutics to treat CRC. The study found that low expression of circEIF3K was associated with prolonged survival time in normal tissues, and PD-L1 was confirmed as an important target for miR-214 in CRC.

BMC CANCER (2021)

添加到收藏夹

Article Biochemical Research Methods

Comparison of eleven in vitro diagnostic assays for the detection of SARS-CoV-2 RNA

G. William Dundon et al.

Summary: This study evaluated the performance of various commercial molecular diagnostic kits and RT-qPCR master mixes, and found that they can be effectively used for the detection of SARS-CoV-2, serving as valid alternatives in low-resource settings.

JOURNAL OF VIROLOGICAL METHODS (2021)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Circular RNA circ_0003028 contributes to tumorigenesis by regulating GOT2 via miR-1298-5p in non-small cell lung cancer

Hongjun Guan et al.

Summary: In NSCLC, circ_0003028 and GOT2 were upregulated, while miR-1298-5p was decreased. Knockdown of circ_0003028 suppressed cell proliferative ability, migration, invasion, angiogenesis, and promoted apoptosis and autophagy in NSCLC cells. Mechanistically, circ_0003028 regulated GOT2 expression by sponging miR-1298-5p, leading to inhibition of NSCLC progression.

BIOENGINEERED (2021)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Circular RNA circ_0008274 upregulates granulin to promote the progression of hepatocellular carcinoma via sponging microRNA-140-3p

Chanchan Gao et al.

Summary: This study found that circ_0008274 is highly expressed in HCC, promoting proliferation, migration, and invasion of HCC cells. Depleting circ_0008274 inhibits malignant behaviors, with the mechanism involving upregulation of GRN to expedite HCC progression.

BIOENGINEERED (2021)

添加到收藏夹

Article Cell Biology

Circ0001320 inhibits lung cancer cell growth and invasion by regulating TNFAIP1 and TPM1 expression through sponging miR-558

Yong Mao et al.

Summary: The study demonstrated that circ0001320 inhibits the growth and invasion of lung cancer cells through the miR-558/TNFAIP1 and TPM1 pathways, while miR-558 has opposite effects. This indicates that circ0001320, TNFAIP1, and TPM1 could be potential markers and therapeutic targets for lung cancer.

HUMAN CELL (2021)

添加到收藏夹

Article Medicine, Research & Experimental

MicroRNA-181d-5p-Containing Exosomes Derived from CAFs Promote EMT by Regulating CDX2/HOXA5 in Breast Cancer

Hongbin Wang et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2020)

添加到收藏夹

Article Medicine, Research & Experimental

CircACAP2 promotes breast cancer proliferation and metastasis by targeting miR-29a/b-3p-COL5A1 axis

Beiyong Zhao et al.

LIFE SCIENCES (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

CAF secreted miR-522 suppresses ferroptosis and promotes acquired chemo-resistance in gastric cancer

Haiyang Zhang et al.

MOLECULAR CANCER (2020)

添加到收藏夹

Article Oncology

Circ_0072083 interference enhances growth-inhibiting effects of cisplatin in non-small-cell lung cancer cells via miR-545-3p/CBLL1 axis

Huiping Li et al.

CANCER CELL INTERNATIONAL (2020)

添加到收藏夹

Article Oncology

Cancer-associated fibroblasts enhance the chemoresistance of CD73(+) hepatocellular carcinoma cancer cells via HGF-Met-ERK1/2 pathway

Hao Peng et al.

ANNALS OF TRANSLATIONAL MEDICINE (2020)

添加到收藏夹

Article Oncology

CircZFR functions as a sponge of miR-578 to promote breast cancer progression by regulating HIF1A expression

Zhuo Chen et al.

CANCER CELL INTERNATIONAL (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Prognostic Role of Circular RNAs Expression in Bladder Carcinoma: A Meta-Analysis

Siyuan Wang et al.

GENETIC TESTING AND MOLECULAR BIOMARKERS (2020)

添加到收藏夹

Article Cell Biology

Nitidine chloride possesses anticancer property in lung cancer cells through activating Hippo signaling pathway

Jing Zhang et al.

CELL DEATH DISCOVERY (2020)

添加到收藏夹

Article Oncology

CircRNA_102272 Promotes Cisplatin-Resistance in Hepatocellular Carcinoma by Decreasing MiR-326 Targeting of RUNX2

Yonghai Guan et al.

CANCER MANAGEMENT AND RESEARCH (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

CircRNA-SORE mediates sorafenib resistance in hepatocellular carcinoma by stabilizing YBX1

Junjie Xu et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Identifying cancer-associated fibroblasts as emerging targets for hepatocellular carcinoma

Jie Zhang et al.

CELL AND BIOSCIENCE (2020)

添加到收藏夹

Article Gastroenterology & Hepatology

circZFR promotes cell proliferation and migration by regulating miR-511/AKT1 axis in hepatocellular carcinoma

Xin Yang et al.

DIGESTIVE AND LIVER DISEASE (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

CAFs secreted exosomes promote metastasis and chemotherapy resistance by enhancing cell stemness and epithelial-mesenchymal transition in colorectal cancer

J. L. Hu et al.

MOLECULAR CANCER (2019)

添加到收藏夹

Article Oncology

Intratumoral plasmacytoid dendritic cells as a poor prognostic factor for hepatocellular carcinoma following curative resection

Zheng-Jun Zhou et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2019)

添加到收藏夹

Article Oncology

Exosomal miRNA-106b from cancer-associated fibroblast promotes gemcitabine resistance in pancreatic cancer

Yuan Fang et al.

EXPERIMENTAL CELL RESEARCH (2019)

添加到收藏夹

Article Medicine, General & Internal

NCAPG2 overexpression promotes hepatocellular carcinoma proliferation and metastasis through activating the STAT3 and NF-κB/miR-188-3p pathways

Fanzheng Meng et al.

EBIOMEDICINE (2019)

添加到收藏夹

Article Cell Biology

RPN2 promotes metastasis of hepatocellular carcinoma cell and inhibits autophagy via STAT3 and NF-κB pathways

Linsheng Huang et al.

AGING-US (2019)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Silencing circZFR inhibits the proliferation, migration and invasion of human renal carcinoma cells by regulating miR-206

Mi Wang et al.

ONCOTARGETS AND THERAPY (2019)

添加到收藏夹

Article Cell Biology

CircRNA-5692 inhibits the progression of hepatocellular carcinoma by sponging miR-328-5p to enhance DAB2IP expression

Zhenguo Liu et al.

CELL DEATH & DISEASE (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

CircZFR promotes hepatocellular carcinoma progression through regulating miR-3619-5p/CTNNB1 axis and activating Wnt/β-catenin pathway

Aichun Tan et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

CircZFR serves as a prognostic marker to promote bladder cancer progression by regulating miR-377/ZEB2 signaling

Wen-Yuan Zhang et al.

BIOSCIENCE REPORTS (2019)

添加到收藏夹

Article Genetics & Heredity

Cancer-associated fibroblasts promote the stemness of CD24+ liver cells via paracrine signaling

Yawen Li et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2019)

添加到收藏夹

Article Cell Biology

Circ_0001955 facilitates hepatocellular carcinoma (HCC) tumorigenesis by sponging miR-516a-5p to release TRAF6 and MAPK11

Zhicheng Yao et al.

CELL DEATH & DISEASE (2019)

添加到收藏夹

Article Cell Biology

CircRNA_101505 sensitizes hepatocellular carcinoma cells to cisplatin by sponging miR-103 and promotes oxidored-nitro domain-containing protein 1 expression

Yanwei Luo et al.

CELL DEATH DISCOVERY (2019)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Exosomal miR-196a derived from cancer-associated fibroblasts confers cisplatin resistance in head and neck cancer through targeting CDKN1B and ING5

Xing Qin et al.

GENOME BIOLOGY (2019)

添加到收藏夹

Article Oncology

Circular RNA-ZFR Inhibited Cell Proliferation and Promoted Apoptosis in Gastric Cancer by Sponging miR-130a/miR-107 and Modulating PTEN

Tonglei Liu et al.

CANCER RESEARCH AND TREATMENT (2018)

添加到收藏夹

Article Oncology

Three Dimensional Mixed-Cell Spheroids Mimic Stroma-Mediated Chemoresistance and Invasive Migration in hepatocellular carcinoma

Iftikhar Ali Khawar et al.

NEOPLASIA (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

Hsa_circRNA_103809 regulated the cell proliferation and migration in colorectal cancer via miR-532-3p/FOXO4 axis

Longjun Bian et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

添加到收藏夹

Article Oncology

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Freddie Bray et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2018)

添加到收藏夹

Article Medicine, General & Internal

Cancer-associated fibroblasts contribute to oral cancer cells proliferation and metastasis via exosome-mediated paracrine miR-34a-5p

Yao-yin Li et al.

EBIOMEDICINE (2018)

添加到收藏夹

Article Oncology

Hepatocellular carcinoma-derived exosomal miRNA-21 contributes to tumor progression by converting hepatocyte stellate cells to cancer-associated fibroblasts

Yuan Zhou et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2018)

添加到收藏夹

Article Gastroenterology & Hepatology

Circular RNA circMTO1 Acts as the Sponge of MicroRNA-9 to Suppress Hepatocellular Carcinoma Progression

Dan Han et al.

HEPATOLOGY (2017)

添加到收藏夹

Article Oncology

Loss of exosomal miR-320a from cancer-associated fibroblasts contributes to HCC proliferation and metastasis

Zhuochao Zhang et al.

CANCER LETTERS (2017)

添加到收藏夹

Article Cell Biology

Chemotherapy resistance and metastasis-promoting effects of thyroid hormone in hepatocarcinoma cells are mediated by suppression of FoxO1 and Bim pathway

Hsiang-Cheng Chi et al.

CELL DEATH & DISEASE (2016)

添加到收藏夹

Review Biochemistry & Molecular Biology

Microenvironmental regulation of tumor progression and metastasis

Daniela F. Quail et al.

NATURE MEDICINE (2013)

添加到收藏夹

Editorial Material Oncology

Tumor Microenvironment Complexity: Emerging Roles in Cancer Therapy

Melody A. Swartz et al.

CANCER RESEARCH (2012)

添加到收藏夹

Article Oncology

Treatment of hepatocellular carcinoma (HCC) with systemic chemotherapy combining epirubicin, cisplatinum and infusional 5-fluorouracil (ECF regimen)

E Boucher et al.

CANCER CHEMOTHERAPY AND PHARMACOLOGY (2002)

添加到收藏夹

Cancer-associated fibroblast exosomes promote chemoresistance to cisplatin in hepatocellular carcinoma through circZFR targeting signal transducers and activators of transcription (STAT3)/nuclear factor -kappa B (NF-κB) pathway

相关参考文献

导出引文

分享论文