☆ 4.7 Article

Exploring anti-liver cancer targets and mechanisms of oxyresveratrol: in silico and verified findings

BIOENGINEERED (2021)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Biochemical Research Methods

Therapeutic targets and signaling mechanisms of vitamin C activity against sepsis: a bioinformatics study

Rong Li et al.

Summary: Network pharmacology analysis identified primary targets, biological processes, and signaling pathways of vitamin C (VC) action against sepsis. The study indicated that VC may exert its effects against sepsis by suppressing immune dysfunction-related and inflammation-associated functional processes.

BRIEFINGS IN BIOINFORMATICS (2021)

添加到收藏夹

Article Biochemical Research Methods

Integrative pharmacological mechanism of vitamin C combined with glycyrrhizic acid against COVID-19: findings of bioinformatics analyses

Rong Li et al.

Summary: This study uncovered the pharmacological mechanism underlying combined VC and GA treatment for COVID-19 using bioinformatic network pharmacology, suggesting that this combination therapy could enhance immunity, suppress inflammation, and activate multiple signaling pathways with potential antimicrobial effects.

BRIEFINGS IN BIOINFORMATICS (2021)

添加到收藏夹

Article Biochemical Research Methods

Integrated omics analysis reveals the alteration of gut microbe-metabolites in obese adults

Rong Li et al.

Summary: Obesity poses a health risk and is a global issue. Recent studies suggest a connection between gut microbiota composition and metabolic disorders, including obesity. Changes in gut microbiota may affect gut metabolites, leading to alterations in host metabolism related to glycolysis, tricarboxylic acid cycle, and homolactic fermentation. Integrated metabolomic analysis reveals possible correlations between dysregulated metabolites in the gut and host, such as L-phenylalanine, L-tyrosine, uric acid, kynurenic acid, cholesterol sulfate, and glucosamine, which are associated with metabolic disorders like obesity and diabetes.

BRIEFINGS IN BIOINFORMATICS (2021)

添加到收藏夹

Article Environmental Sciences

Functional benefit and molecular mechanism of vitamin C against perfluorooctanesulfonate-associated leukemia

Rong Li et al.

Summary: The study revealed the potential pharmacological effects of Vitamin C against PFOS-associated leukemia by suppressing leukemia cell proliferation and tumor growth. Genes such as TP53, MAPK1, ESR1 may serve as potential biomarkers for monitoring and treating PFOS-associated leukemia.

CHEMOSPHERE (2021)

添加到收藏夹

Article Cell Biology

Anti-coronavirus disease 2019 (COVID-19) targets and mechanisms of puerarin

Xingyue Qin et al.

Summary: This study aimed to uncover the pharmacological function and underlying mechanism of puerarin as a potential treatment for COVID-19 using network pharmacology and molecular docking. Puerarin was found to target key proteins involved in oxidative stress, inflammation, and apoptosis to exert its anti-COVID-19 effects. The results also indicated that puerarin may serve as a potential treatment for COVID-19 by targeting specific signaling pathways.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

The use of glutathione to reduce oxidative stress status and its potential for modifying the extracellular matrix organization in cleft lip

Rong Li et al.

Summary: The study utilized bioinformatics methods to identify that the antioxidant glutathione (GSH) may help attenuate oxidative stress and promote facial development in patients with cleft lip (CL) by modulating specific families such as matrix metalloproteinase and integrins. Further validation through RNA sequencing supported this hypothesis.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

添加到收藏夹

Article Cell Biology

Therapeutic targets and molecular mechanism of calycosin for the treatment of cerebral ischemia/reperfusion injury

Songzuo Yu et al.

Summary: This study examined the pivotal anti-CIRI targets and pathways of calycosin through network pharmacology and molecular docking analyses. Calycosin was found to improve endothelial cell proliferation, growth, inflammatory development, and cellular metabolism, primarily through suppression of toll-like receptor, PI3K-AKT, TNF, MAPK, and VEGF signaling pathways, indicating its potential as a treatment for CIRI in future clinical trials.

AGING-US (2021)

添加到收藏夹

Article Biochemical Research Methods

Network Pharmacology and bioinformatics analyses identify intersection genes of niacin and COVID-19 as potential therapeutic targets

Rong Li et al.

Summary: Niacin may have potential therapeutic effects for CRC/COVID-19 by exerting cytoprotection, enhancing immunologic functions, inhibiting inflammatory reactions, and regulating the cellular microenvironment. Five core pharmacological targets of niacin in CRC/COVID-19 were identified.

BRIEFINGS IN BIOINFORMATICS (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Pharmacological biotargets and the molecular mechanisms of oxyresveratrol treating colorectal cancer: Network and experimental analyses

Rong Li et al.

BIOFACTORS (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Challenges in liver cancer and possible treatment approaches

David Anwanwan et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2020)

添加到收藏夹

Article Pharmacology & Pharmacy

Pharmacological targets and molecular mechanisms of plumbagin to treat colorectal cancer: A systematic pharmacology study

Yujia Liang et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2020)

添加到收藏夹

Article Cell Biology

Revealing the targets and mechanisms of vitamin A in the treatment of COVID-19

Rong Li et al.

Aging-US (2020)

添加到收藏夹

Article Cell Biology

Pharmacological targets and mechanisms of calycosin against meningitis

Yuan Nong et al.

AGING-US (2020)

添加到收藏夹

Article Environmental Sciences

Integrative omics analyses uncover the mechanism underlying the immunotoxicity of perfluorooctanesulfonate in human lymphocytes

Rong Li et al.

CHEMOSPHERE (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Anti-colorectal cancer targets of resveratrol and biological molecular mechanism: Analyses of network pharmacology, human and experimental data

Rong Li et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2019)

添加到收藏夹

Review Chemistry, Medicinal

Health benefits of resveratrol: Evidence from clinical studies

Akhand Pratap Singh et al.

MEDICINAL RESEARCH REVIEWS (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

Potential biomarker of fibroblast growth factor 21 in valproic acid-treated livers

Xiaoxiao Xu et al.

BIOFACTORS (2019)

添加到收藏夹

Review Oncology

Management of adverse events associated with tyrosine kinase inhibitors: Improving outcomes for patients with hepatocellular carcinoma

Lorenza Rimassa et al.

CANCER TREATMENT REVIEWS (2019)

添加到收藏夹

Article Environmental Sciences

Bioinformatic and experimental data decipher the pharmacological targets and mechanisms of plumbagin against hepatocellular carcinoma

Rui Zhou et al.

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY (2019)

添加到收藏夹

Review Oncology

ESR1 mutations in breast cancer

Derek Dustin et al.

CANCER (2019)

添加到收藏夹

Review Pathology

ESR1 mutations: a new biomarker in breast cancer

Marcela Carausu et al.

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS (2019)

添加到收藏夹

Article Medicine, Research & Experimental

The Effects of Plumbagin on Pancreatic Cancer: A Mechanistic Network Pharmacology Approach

Qijin Pan et al.

MEDICAL SCIENCE MONITOR (2019)

添加到收藏夹

Review Chemistry, Medicinal

Estrogen signaling: An emanating therapeutic target for breast cancer treatment

Tanmay Saha et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)

添加到收藏夹

Article Pharmacology & Pharmacy

Anti-colorectal cancer biotargets and biological mechanisms of puerarin: Study of molecular networks

Jun Li et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2019)

添加到收藏夹

Article Environmental Sciences

Clinical features of aflatoxin B1-exposed patients with liver cancer and the molecular mechanism of aflatoxin B1 on liver cancer cells

Rui Zhou et al.

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY (2019)

添加到收藏夹

Review Endocrinology & Metabolism

Crosstalk between Estrogen Signaling and Breast Cancer Metabolism

Eylem Kulkoyluoglu-Cotul et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2019)

添加到收藏夹

Article Chemistry, Medicinal

Oxyresveratrol prevents murine H22 hepatocellular carcinoma growth and lymph node metastasis via inhibiting tumor angiogenesis and lymphangiogenesis

Yuanqi Liu et al.

JOURNAL OF NATURAL MEDICINES (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Exosome-delivered EGFR regulates liver microenvironment to promote gastric cancer liver metastasis

Haiyang Zhang et al.

NATURE COMMUNICATIONS (2017)

添加到收藏夹

Article

Anisotropic Patterns of Liver Cancer Prevalence in Guangxi in Southwest China: Is Local Climate a Contributing Factor?

Wei Deng et al.

Asian Pacific Journal of Cancer Prevention (2015)

添加到收藏夹

Article Gastroenterology & Hepatology

Adjunctive traditional Chinese medicine therapy improves survival of liver cancer patients

Yueh-Hsiang Liao et al.

LIVER INTERNATIONAL (2015)

添加到收藏夹

Article Oncology

Incidence and mortality of liver cancer in China in 2011

Ting-Ting Zuo et al.

CHINESE JOURNAL OF CANCER (2015)

添加到收藏夹

Review Oncology

Resveratrol and cancer: focus on in vivo evidence

Lindsay G. Carter et al.

ENDOCRINE-RELATED CANCER (2014)

添加到收藏夹

Article Medicine, General & Internal

Hepatocellular carcinoma

Alejandro Forner et al.

LANCET (2012)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.