期刊
APPLIED SCIENCES-BASEL
卷 12, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/app12020935
关键词
biodegradable materials; biopolymer; liposome; encapsulation methods; degradation mechanisms; therapeutic products
类别
资金
- Australian Postgraduate Award at The University of Queensland
- National Health and Medical Research Council (NHMRC) Grant [APP1107723]
- Queensland Government Smart State Research Facilities Programme
- Therapeutic Innovation Australia (TIA)
- Australian Government through the National Collaborative Research Infrastructure Strategy (NCRIS) program
- Australian National Fabrication Facility (ANFF-Q) at The University of Queensland
- Australian Research Council [LE0775684, LE110100028, LE110100033, LE140100087, LE160100168]
- Australian Research Council [LE110100033, LE110100028, LE140100087, LE160100168] Funding Source: Australian Research Council
Biodegradable polymers have been used as carriers in drug delivery systems for over four decades. They have applications at different scales, from macroscale to nanoscale. These materials have been approved for human use and achieved commercial success. Current research focuses on developing new formulation types for improved drug delivery.
Biodegradable polymers have been used as carriers in drug delivery systems for more than four decades. Early work used crude natural materials for particle fabrication, whereas more recent work has utilized synthetic polymers. Applications include the macroscale, the microscale, and the nanoscale. Since pioneering work in the 1960's, an array of products that use biodegradable polymers to encapsulate the desired drug payload have been approved for human use by international regulatory agencies. The commercial success of these products has led to further research in the field aimed at bringing forward new formulation types for improved delivery of various small molecule and biologic drugs. Here, we review recent advances in the development of these materials and we provide insight on their drug delivery application. We also address payload encapsulation and drug release mechanisms from biodegradable formulations and their application in approved therapeutic products.
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