Controlled Release of Tazarotene from Magnetically Responsive Nanofiber Patch: Towards More Efficient Topical Therapy of Psoriasis

Electrospun polycaprolactone nanofibers with embedded magnetic nanoparticles were developed for use in the topical delivery of antipsoriatic drugs. To test a hydrophobic drug, a tazarotene has been used, which is an efficient retinoid derivative. Such a smart hyperthermia nanofiber system with self-generated heat from the incorporated magnetic nanoparticles induced drug release in response to on-off switching of alternating magnetic fields for the delivery of tazarotene through the skin, as quantified using Franz cells. This highly efficient external field-controllable system with minimal skin irritation could create a new avenue for the topical therapy of psoriasis.

Automated summary

An intelligent hyperthermia nanofiber system was developed by embedding magnetic nanoparticles in electrospun polycaprolactone nanofibers, enabling controlled delivery of tazarotene through the skin using external magnetic fields, with minimal skin irritation. This novel system could potentially provide a new approach for the topical therapy of psoriasis.